Biomolecular Aspects and Update on Treatment of Cerebral Malaria

Husna, Machlusil; Prasetyo, Bowo Hery

doi:10.21776/ub.mnj.2016.002.02.6

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…In severe cases, cerebral malaria will occur in a febrile patient with decreased consciousness [5]. Cerebral malaria is an acute encephalopathy that meets three criteria, namely coma that cannot be awakened, or coma that persists for >30 minutes after the seizure and is accompanied by P. falciparum indicated by a blood smear [20].…”

Section: Pathogenesis Of Malariamentioning

confidence: 99%

Malaria: Transmission, Diagnosis, Treatment and Prevention in Indonesia

Kahar,

Setiadi,

Didik Widiyanto

et al. 2024

Infectious Diseases

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Malaria is a disease caused by Plasmodium and is characterized by recurrent fever, anemia, and hepatosplenomegaly. There are five species of Plasmodium that can infect humans. P. falciparum causes the most deaths, as do P. vivax, P. ovale, and P. malariae which usually cause mild malaria. The aim of this research is to determine the meaning, classification, epidemiology, symptoms, pathogenesis, diagnosis, mode of transmission, prevention, and treatment of malaria. Research method: This research is a descriptive observational study with a literature review design using databases from Google Scholar, accredited national journal Sinta, and reputable international journals such as Scopus, PubMed, Web of Science, and others. The research results show that malaria cases are still high in Indonesia every year. There are several risk factors for malaria such as attitude, behavior, environment, and physical environmental factors where you live, such as (temperature, humidity, livestock pens, houses without screen ventilation, stagnant water, or breeding places). Malaria treatment depends on several factors, including the type of Plasmodium that causes infection, the severity of the disease, and the disease the individual is suffering from. Prevention efforts need to be made by addressing various risk factors for malaria.

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Section: Pathogenesis Of Malariamentioning

confidence: 99%

Malaria: Transmission, Diagnosis, Treatment and Prevention in Indonesia

Kahar,

Setiadi,

Didik Widiyanto

et al. 2024

Infectious Diseases

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“…Demam yang disebabkan oleh P. falciparum dan P. knowlesi dapat terjadi setiap hari. Berbeda dengan P. falciparum, demam akibat infeksi P. vivax atau P. ovale memiliki interval 1 hari, sedangkan demam pada P. malariae terjadi dengan interval 2 hari (Husna & Hery Prasetyo, 2016;Singh & Daneshvar, 2013). Selain demam, malaria juga dapat menyebabkan anemia.…”

Section: Kajian Pustakaunclassified

Pemberdayaan Karang Taruna Desa Hurun Dalam Pencegahan dan Penanggulangan Kejadian Malaria di Desa Hurun Teluk Pandan Kabupaten Pesawaran

Huda,

Yuniza,

Hartanti

2024

Creat J. Cumn Enga

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ABSTRAK Desa Hurun merupakan desa dengan kondisi topografi yang menunjang untuk perindukan nyamuk malaria. Di desa Hurun terdapat 3 lahan tambak yang terbengkalai dan sangat potensial bagi perindukan nyamuk malaria, sehingga kejadian malaria terus ada dan harus diantisipasi dan ditanggulangi. Usaha penanggulangan dan eliminasi malaria perlu dilakukan secara terus menerus dan terkoordinasi, baik melalui aparat desa, maupun melalui kelompok masyarakat yang aktif berkarya. Salah satu kelompok masyarakat yang aktif melaksanakan kegiatan di desa Hurun adalah Karang Taruna. Masyarakat sangat berperan penting dalam penemuan kasus malaria, termasuk pemuda yang tergabung dalam karang taruna. Oleh karena itu, diperlukan suatu kegiatan untuk meningkatkan kapasitas anggota karang taruna dalam melakukan penemuan kasus malaria di desa Hurun. Meningkatkan peran serta masyarakat dan karang taruna dalam mencegahan penyakit malaria. Penyuluhan kepada masyarakat, pelatihan pembuatan slide malaria bagi anggota karang taruna, pemberian revelens, serta pemasangan kawat nyamuk pada ventilasi rumah warga. Setelah dilakukan kegiatan pengabdian, terlihat adanya peningkatan pengetahuan dan pemahaman peserta mengenai malaria. Antusiasme peserta terhadap kegiatan pengabdian yang dilakukan juga sangat baik. Kegiatan pengabmas yang dilakukan berhasil meningkatkan pemahaman dan pengetahuan peserta mengenai malaria, memberi pengetahuan dan keterampilan kepada anggota divisi kesehatan karang taruna dalam pembuatan slide tebal dan tipis, memberikan motivasi kepada anggota karang taruna dan aparat desa akan penting pencegahan kasus malaria dengan pemberian revelen dan obat anti nyamuk serta percontohan pemasangan kawat nyamuk pada rumah masyarakat. Kata Kunci: Malaria, Penyuluhan Masyarakat, Karang Taruna ABSTRACT Hurun Village is characterized by topographic conditions conducive to the breeding of malaria mosquitoes. Within the village, there are three abandoned ponds with significant potential for breeding malaria mosquitoes, contributing to the persistent incidence of malaria. Effective control and elimination efforts require continuous and coordinated action, involving both village officials and actively engaged community groups. Among these groups, Karang Taruna stands out for its proactive involvement in Hurun Village. The community, particularly its youth organizations, plays a pivotal role in malaria case detection. Thus, enhancing the capacity of Karang Taruna members in detecting malaria cases in Hurun Village is essential. This study aims to enhance community and Karang Taruna participation in malaria prevention efforts. Our approach involved community outreach, training sessions on malaria case detection for Karang Taruna members, provision of equipment to interrupt the malaria transmission chain, and the installation of mosquito nets in residents' homes. Following the implementation of these service activities, there was a notable increase in participants' knowledge and understanding of malaria. This improvement was particularly valuable as participants demonstrated high enthusiasm and receptiveness to the activities. The community service activities undertaken successfully heightened participants' understanding and knowledge of malaria. Additionally, they equipped members of the Karang Taruna health division with essential skills for conducting thick and thin blood smears. The activities also fostered motivation among Karang Taruna members and village officials to prioritize malaria prevention, emphasizing the importance of providing relevant anti-mosquito medications and piloting mosquito net installations in households. Keywords: Malaria, Community Education, Karang Taruna

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“…falciparum merupakan penyebab penyakit malaria tropika dan dapat menyebabkan malaria berat karena dapat menyebabkan malaria cerebral (Fitriany, 2018;Reich et al, 2001). Eritrosit yang terinfeksi P. falciparum akan mengalami proses sekuestrasi, sitoadherens dan rosseting (Dinko & Pradel, 2016;Husna & Prasetyo, 2016). ini sejalan dengan temuan (Igbeneghu et al, 2012) yang melaporkan bahwa individu O tampaknya paling terlindungi dari kepadatan parasit yang tinggi.…”

Section: Pembahasanunclassified

Tingkat Parasitemia Penderita Malaria Berdasarkan Golongan Darah ABO di Kota Jayapura

Sahli,

Asrianto,

Kurniawan

et al. 2021

j.kesehatan metro sai wawai

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Background: Malaria is the world's leading parasitic infectious disease caused by protozoa of the genus Plasmodium. An association between ABO blood type and malaria infection has been reported, but the results are conflicting. Purpose: This study aims to determine the level of parasitemia in malaria patients based on ABO blood type. Methods: This research is an analytic study with a cross-sectional design. The variables studied were the ABO blood group and the level of parasitemia. The number of samples in this study was 63 samples. Results: The results of the study from 63 samples showed that the highest prevalence of blood type was in blood type O by 38 people (60.3%), then followed by blood types A and B with 17 people (27.0%) and eight people (12.7%) and no blood type AB was found. At the same time, the prevalence of P. falciparum was 44 (69.8%), while P. vivax was 19 people (30.2%). Infection by P. falciparum based on the highest ABO blood group was found in blood groups B by 75%, A (70.6%), and O (68.4%). Meanwhile, the highest level of parasitemia (positive 4) P. falciparum infection was found in blood group B (50%), followed by blood group O and blood group A, each with 0%. The results of the bivariate analysis of Fisher's test obtained P-value = 0.016 (0.016 0.05), which means a statistically significant relationship between ABO blood type and the level of parasitemia. Conclusion: There is an increase in parasitemia in malaria patients based on ABO blood type in Jayapura City. Blood type O is the most common blood type in malaria patients in Jayapura City.Abstrak. Latar Belakang: Malaria adalah penyakit infeksi parasit terkemuka di dunia yang disebabkan oleh protozoa dari genus Plasmodium. Hubungan antara golongan darah ABO dan infeksi malaria telah dilaporkan, tetapi hasilnya bertentangan. Tujuan: Penelitian ini bertujuan untuk mengetahui Tingkat parasitemia pada penderita malaria berdasarkan golongan darah ABO. Metode: penelitian ini merupakan penelitian analitik dengan desain crossexional. Variabel yang diteliti adalah variable golongan darah ABO dan tingkat parasitemia. Jumlah sampel dalam penelitian ini sebesar 63 sampel. Hasil: Hasil Penelitian dari 63 sampe menunjukan prevalensi golongan darah terbanyak terdapat pada golongan darah O sebesar 38 orang (60,3 %), kemudian diikuti golongan darah A dan B masing-masing sebesar 17 orang (27,0%) dan 8 orang (12,7%) dan tidak ditemukan golongan darah AB. Sedangkan prevalensi P. falciparum sebesar 44 (69,8%) sedangkan P.vivax sebesar 19 orang (30,2%). Infeksi oleh P. falciparum berdasarkan golongan darah ABO tertinggi terdapat pada golongan darah B sebesar 75%, A (70,6%) dan O (68,4%). Sedangkan tingkat parasitemia tertinggi (positif 4) infeksi P. falciparum terdapat pada golongan darah B (50%) dan diikuti dengan golongan darah O dan golongan darah A masing-masing 0%. Hasil analisis bivariat uji Fisher didapatkan nilai P= 0,016 (0,016 0,05) yang artinya secara statistik ada hubungan yang signifikan antara golongan darah ABO dengan tingkat parasitemia. Simpulan: Ada peningkatan tingkat parasitemia pada penderita malaria berdasarkan golongan darah ABO di Kota Jayapura. Golongan darah O adalah golongan darah yang paling umum pada pasien malaria di Kota Jayapura.

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Biomolecular Aspects and Update on Treatment of Cerebral Malaria

Cited by 3 publications

References 19 publications

Malaria: Transmission, Diagnosis, Treatment and Prevention in Indonesia

Malaria: Transmission, Diagnosis, Treatment and Prevention in Indonesia

Pemberdayaan Karang Taruna Desa Hurun Dalam Pencegahan dan Penanggulangan Kejadian Malaria di Desa Hurun Teluk Pandan Kabupaten Pesawaran

Tingkat Parasitemia Penderita Malaria Berdasarkan Golongan Darah ABO di Kota Jayapura

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