Biomodulative Effects of Polarized Light on the Healing of Cutaneous Wounds on Nourished and Undernourished Wistar Rats

Abstract

It is concluded that nutritional status influenced the progression of the healing process as well as the quality of the healed tissue, and that the use of polarized light resulted in a positive biomodulatory effect.

Low‐level light stimulates excisional wound healing in mice

“…These reports can be separated into two broad groups depending on whether the animals used were normal, or whether they had been manipulated in some way to depress wound healing. These manipulations employed to impair normal wound healing include diabetes [26], ionizing radiation [27], treatment with corticosteroids [28], or malnourishment [29]. Indeed, it has been asserted that normal healthy rodents may not be a suitable model for studying LLLT effects on wound healing [30].…”

Juvenile Spondyloarthritis

“…Laser therapy is used in many biomedical sciences to promote tissue regeneration (Mester, Mester et al 1985;Karu 1999). Many studies involving the low-level laser therapy have shown that the healing process is enhanced by such therapy (Enwemeka 1988;Rochkind, Rousso et al 1989;Nemeth 1993;Grossman, Schneid et al 1998;O'Brien, Li et al 1998;Lilge, Tierney et al 2000;Maegawa, Itoh et al 2000;Schlager, Kronberger et al 2000;Sommer, Pinheiro et al 2001;Wong-Riley, Bai et al 2001; do Nascimento, Pinheiro et al 2004;Eells, Wong-Riley et al 2004;Pinheiro, Meireles et al 2004;Hawkins, Houreld et al 2005). In Table 5 we show the results of LLLT therapy in the pilot study of 38 children with jSpA diagnosed based on both ESSG and ILAR criteria, which we treated, in addition to standard NSAID therapy, with LLLT (Harjacek and Lamot 2008).…”

Modelos experimentais de desnutrição e sua influência no trofismo cutâneo

“…In agree ment with reports publis hed in the lite ra tu re, the expe ri men tal induc tion of maras mus in rats was con fir med by their weight and by the cli ni cal signs pre sen ted by the ani mals. 2,6,8,11,12 With res pect to serum albu min levels, the results were simi lar in the well-nou ris hed and mal nou ris hed groups after 60 days of fol low-up, pos sibly due to the slow, bela ted reduc tion in albu min levels in maras mus. 2,6 Similar results were found with the gela tin model in which a diet con tai ning low qua lity pro tein was used.…”

“…Serum albu min levels remain prac ti cally unchan ged, with decrea ses only being detec ted at a later stage. 4,[6][7][8]12 In addi tion to this type of mal nu tri tion, ano ther type may be trig ge red when the die tary inta ke of speci fic nutrients such as pro tein is insuf fi cient or when inta ke is based on poor qua lity pro tein such as gelatin. Gelatin is a dena tu red col la gen, the amino acid com po si tion of which con sists of a high con cen tra tion of glyci ne, pro li ne and hydroxy pro li ne asso cia ted with a low or negli gi ble con cen tra tion of tyro si ne, trypto pha ne, iso leu ci ne, cysti ne and his ti di ne.…”

“…Malnutrition results in chan ges in inflam ma tory reac tion, immu ne func tion and tis sue rege ne ra tion, lea ding to an increa se in proin flam ma tory cyto ki nes, a delay in the hea ling process and a grea ter risk of infec tion. 2,6,12,15,16 Frade et al analy zed a sam ple of 124 patients in Juiz de Fora and sur roun ding region and found that leg ulcers repre sen ted a pro trac ted, recur rent con dition that is gene rally asso cia ted with other chro nic illnes ses, prin ci pally affec ting the low-inco me elderly popu la tion. 17 Within the pre sent sce na rio of increased inci den ce and pre va len ce of gene rally mal nou rished patients with ulcers and the various the ra peu tic options avai la ble to acce le ra te the hea ling pro cess, it has beco me impor tant to stan dar di ze and obtain more infor ma tion on the expe ri men tal models of malnu tri tion in order to eva lua te the mecha nisms involved in tis sue repair and, con se quently, to assess the safety and effi cacy of these pro ducts.…”