Juvenile Spondyloarthritis

Harjaček, Miroslav; Lamot, Lovro; Tambic, Lana; Vidović, Mandica; Joos, Rik

doi:10.5772/39149

Cited by 4 publications

(4 citation statements)

References 101 publications

(123 reference statements)

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“…20% of our patients had corticosteroids and 10% received methotrexate. This matches with Miroslav et al (23) who stated that methotrexate as second line agent is a good option in other forms of JIA. However, its use in juvenile AS is limited.…”

Section: Discussionsupporting

confidence: 88%

Different Patterns of Juvenile Idiopathic Arthritis in Zagazig University Hospitals Mohamed Abd-Elkader Almalky, Ehab Mahmoud Rasheed,

Almalky

Rasheed

Mortada

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Pediatric rheumatic diseases can cause considerable disease burden to children and their families. They are associated with the potential for physical disability, diminished quality of life and significant direct and indirect costs. Objective: We aimed to describe the clinical spectrum and the frequencies and different patterns of Juvenile idiopathic arthritis (JIA) in children in Zagazig University Hospitals. Patients and methods: A cross-sectional study included 68 cases with Juvenile idiopathic arthritis < 16 years. The study was conducted over two years from December 2017 to December 2019. Investigations as complete blood count, C reactive protein, antinuclear antibody (ANA), rheumatoid factor (RF), complement C3 & C4, creatine phosphokinase, and EMG. Management and treatment plans were achieved and data about the results were collected. Results: Most of patients diagnosed with rheumatological diseases were females. Oligoarticular JIA was the commonest subtype of JIA in our study followed by polyarticular then systemic onset type. NSAIDs was the commonest drug used by JIA patients followed by methotrexate then corticosteroids. Conclusion: Early diagnosis and effective management of these children is essential so that they can lead a normal or near normal life especially in patients with rheumatological diseases with chronic morbidity as JIA.

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Section: Discussionsupporting

confidence: 88%

Different Patterns of Juvenile Idiopathic Arthritis in Zagazig University Hospitals Mohamed Abd-Elkader Almalky, Ehab Mahmoud Rasheed,

Almalky

Rasheed

Mortada

et al. 2021

The Egyptian Journal of Hospital Medicine

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“…Spondyloarthritis (SpA) includes a group of immune-mediated inflammatory diseases with similar genetic and clinical manifestations, including ankylosing spondylitis (AS), psoriatic arthritis (PsA) and juvenile SpA (JSA) ( 1 , 2 ). In particular, JSA is a group of chronic inflammatory diseases associated with human leukocyte antigen B27, affecting children at ≤16 years of age.…”

Section: Introductionmentioning

confidence: 99%

Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis

et al. 2018

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The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed to identify differentially expressed genes (DEGs) associated with disease characteristics. Additionally, Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the DEGs were performed. Protein-protein, microRNA-transcription factor and chemical-gene interaction networks were constructed. A total of 326 DEGs, 196 upregulated and 130 downregulated, were identified. DEGs, including C-X-C motif chemokine ligand 5 (CXCL5), BCL2 interacting protein 3 like (BNIP3L), dual specificity phosphatase 5 (DUSP5) and tumor protein p53 (TP53) were enriched in functions associated with apoptosis, the cell cycle and immune responses. KEGG pathway enrichment analysis revealed that pathways associated with inflammation and the mitogen-activated protein kinase 1 (MAPK) signaling pathway were the most enriched by DEGs. The results of the present study indicated that the MAPK signaling pathway and four genes, including CXCL5, BNIP3L, DUSP5 and TP53, may be implicated in the pathogenesis of JSA.

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“…In children, enthesitis-related arthritis (ErA) is a subgroup of juvenile idiopathic arthritis (JIA) clinically characterized by enthesitis, chronic inflammatory arthritis, acute anterior uveitis, back pain, and low-grade gut inflammation. ErA also falls under the collective term of juvenile spondyloarthritis (jSpA) (1). Depending on the geographic region, ErA accounts for 15-30% JIA cases and is one of the commonest subtype of JIA seen in Asia (2).…”

Section: Introductionmentioning

confidence: 99%

“…The jSpA commonly starts as "undifferentiated" disease (e.g., ERA) which differs between children and adults. For example, in juvenileonset disease (jSpA), when compared to adults, hip arthritis is more frequently observed, there is a lower prevalence of human leukocyte antigen B27 positivity, axial involvement and acute anterior uveitis, but less peripheral arthritis and enthesitis (1). Although several classification criteria are used in children for uniformity of diagnoses, several other conditions share similar clinical features, thus resulting in either overlap or indistinct classifications.…”

Section: Introductionmentioning

confidence: 99%

Immunopathophysiology of Juvenile Spondyloarthritis (jSpA): The “Out of the Box” View on Epigenetics, Neuroendocrine Pathways and Role of the Macrophage Migration Inhibitory Factor (MIF)

Harjaček

2021

Front. Med.

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Juvenile spondyloarthritis (jSpA) is a an umbrella term for heterogeneous group of related seronegative inflammatory disorders sharing common symptoms. Although it mainly affects children and adolescents, it often remains active during adulthood. Genetic and environmental factors are involved in its occurrence, although the exact underlying immunopathophysiology remains incompletely elucidated. Accumulated evidence suggests that, in affected patients, subclinical gut inflammation caused by intestinal dysbiosis, is pivotal to the future development of synovial–entheseal complex inflammation. While the predominant role of IL17/23 axis, TNF-α, and IL-7 in the pathophysiology of SpA, including jSpA, is firmly established, the role of the cytokine macrophage migration inhibitory factor (MIF) is generally overlooked. The purpose of this review is to discuss and emphasize the role of epigenetics, neuroendocrine pathways and the hypothalamic-pituitary (HPA) axis, and to propose a novel hypothesis of the role of decreased NLRP3 gene expression and possibly MIF in the early phases of jSpA development. The decreased NLRP3 gene expression in the latter, due to hypomethylation of promotor site, is (one of) the cause for inflammasome malfunction leading to gut dysbiosis observed in patients with early jSpA. In addition, we highlight the role of MIF in the complex innate, adaptive cellular and main effector cytokine network, Finally, since treatment of advanced bone pathology in SpA remains an unmet clinical need, I suggest possible new drug targets with the aim to ultimately improve treatment efficacy and long-term outcome of jSpA patients.

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Juvenile Spondyloarthritis

Cited by 4 publications

References 101 publications

Different Patterns of Juvenile Idiopathic Arthritis in Zagazig University Hospitals Mohamed Abd-Elkader Almalky, Ehab Mahmoud Rasheed,

Different Patterns of Juvenile Idiopathic Arthritis in Zagazig University Hospitals Mohamed Abd-Elkader Almalky, Ehab Mahmoud Rasheed,

Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis

Immunopathophysiology of Juvenile Spondyloarthritis (jSpA): The “Out of the Box” View on Epigenetics, Neuroendocrine Pathways and Role of the Macrophage Migration Inhibitory Factor (MIF)

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