Biomodels of Bone: A Review

Lohfeld, Stefan; Barron, Valerie; McHugh, Peter E.

doi:10.1007/s10439-005-5873-x

Cited by 65 publications

(46 citation statements)

References 72 publications

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“…Geometric modelling of biological structures by using tools based on computer-aided design (CAD) is currently applied to disease diagnosis [10,11], design of medical devices [12,13], and geometric reconstruction for different purposes [14,15]. More specifically, in the field of ophthalmology, there are several studies that use CAD methods to develop the concept of a patient-specific model [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus

et al. 2017

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Abstract:The aim of this study is to describe a new keratoconus detection method based on the analysis of certain parametric morphogeometric operators extracted from a custom patient-specific three-dimensional (3D) model of the human cornea. A corneal geometric reconstruction is firstly performed using zonal functions and retrospective Scheimpflug tomography data from 107 eyes of 107 patients. The posterior corneal surface is later analysed using an optimised computational geometry technique and the morphology of healthy and keratoconic corneas is characterized by means of geometric variables. The performance of these variables as predictors of a new geometric marker is assessed through a receiver operating characteristic (ROC) curve analysis and their correlations are analysed through Pearson or Spearman coefficients. The posterior apex deviation variable shows the best keratoconus diagnosis capability. However, the strongest correlations in both healthy and pathological corneas are provided by the metrics directly related to the thickness as the sagittal plane area at the apex and the sagittal plane area at the minimum thickness point. A comparison of the screening of keratoconus provided by the Sirius topographer and the detection of corneal ectasia using the posterior apex deviation parameter is also performed, demonstrating the accuracy of this characterization as an effective marker of the diagnosis and ectatic disease progression.

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Section: Introductionmentioning

confidence: 99%

A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus

et al. 2017

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“…The biocompatibility of scaffolds has to be similar with the one of the human bone, from the mechanical, chemical and biological point of view [7]. Also the biocompatible material must have the possibility to perform as a substrate that will support the appropriate cellular activity and also to optimize tissue generation [8,9]. Other important characteristics are the biomechanical properties of the total hip replacement produced by SLS technology which should be the closest to the human bone properties.…”

Section: Introductionmentioning

confidence: 99%

The influence of build orientation on the mechanical properties of medical implants made from PA 2200 by Selective Laser Sintering

Păcurar

Petrilak

2017

MATEC Web Conf.

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Abstract. This paper presents a series of research that have been made by the authors in the field of medical implants realized from PA 2200 powder material using the Selective Laser Sintering (SLS) method. Several sets of samples differently oriented into the working area of the machine were manufactured from PA 2200 by SLS, in order to determine which is the recommended orientation to be used during the manufacturing process, in such a way that at the end the mechanical properties (e.g. Compressive strength, Young's modulus, etc.) will be as closed as possible to the ones of the human bones. The obtained results were further on used in the case of a medical implant (Acetabular liner) that was manufactured at the Technical University of Cluj-Napoca (TUCN) from PA 2200 material using the DTM Sinterstation 2000 SLS equipment.

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“…Numerical (computer) and physical model are important tools for engineers, scientists, and experts in any filed to help understand physical phenomena, to analyze physical objects and systems, as well as to perform design. Physical models range from simple bone models mounted on a testing jig to more complex Bio-models rendered in solid form that can be produced by engineering technologies such as rapid prototyping technologies, which replicate the morphology of the bone structure [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, new and efficient production process, based around rapid prototyping (RP) technologies, is currently revolutionizing the generation of physical models [2]. In recent years, the advances in computing technologies and production processes, both terms of hardware and software have led to the using of Computer Aided Design (CAD) in biomedical engineering that is a technological field, which includes medicine engineering, tissue engineering, genetic technology, medical treatment engineering [3], in applications, ranging from clinical medicine, and customized medical implant to tissue engineering [4].…”

Section: Introductionmentioning

confidence: 99%

3D Bio-Cad modeling of human mandible and fabrication by rapid-prototyping technology

Ay¹,

Kubat²,

Delilbaşi³

et al. 2013

uujms

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The purpose of this study is to prepare a model of the human mandible in accordance with anatomical structure and fabricated by rapid-prototyping (RP) technology. In this study, a computed tomographic (CT) scan of a dentate mandible was obtained with a 0.3 mm voxel resolution with capability to export to DICOM format. The data were cleaned; edited and separated 'mask' generated for cortical bone, cancellous bone, and teeth using Mimics 10.01 and Geomagic 11.0 software. The data were imported to Solidworks from Geomagic and converted to the solid model and fabricated by 3D rapid-prototyping technique. The mandible structure was divided into layers and then an average Young's modulus value was calculated for each layer of cortical bone and cancellous bone using the basis of CT density as in previously published protocols. In this study, the procedure of obtaining bio-CAD model of mandible methodology has nine phases: computed tomography (CT), 2D segmentation, calculating 3D object from scanned data, reverse engineering interface, point cloud data processing, surface reconstruction, solid model reconstruction, obtaining bio-CAD model, and fabricating the model using RP technology. The average Young's Modulus value of cortical bone and cancellous bone was calculated 30100.88 MPa, and 685.42 MPa, respectively. As a result, according to expert review, examination of the anatomical structure, and literature survey, we concluded that the development of 3D human mandible model can be used to conduct research on human mandible.

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Biomodels of Bone: A Review

Cited by 65 publications

References 72 publications

A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus

A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus

The influence of build orientation on the mechanical properties of medical implants made from PA 2200 by Selective Laser Sintering

3D Bio-Cad modeling of human mandible and fabrication by rapid-prototyping technology

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