Biomimetically-mineralized composite coatings on titanium functionalized with gelatin methacrylate hydrogels

Tan, Guoxin; Zhou, Lei; Ning, Chengyun; Tan, Ying; Ni, Guo‐Xin; Liao, Jingwen; Yu, Peng; Chen, Xiaofeng

doi:10.1016/j.apsusc.2013.04.088

Cited by 65 publications

(51 citation statements)

References 34 publications

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“…GelMA-hydroxyapatite hybrids was also proposed as coatings for titanium (Ti) surfaces to improve the integration between titanium and bone implants [82]. In this application, the titanium surfaces were first hydroxylated by alkali treatment and then covalently coated with a GelMA film.…”

Section: Hybrid Hydrogels Based On Gelmamentioning

confidence: 99%

“…In this application, the titanium surfaces were first hydroxylated by alkali treatment and then covalently coated with a GelMA film. Immersion of the GelMA-coated Ti constructs into a solution that mimics concentrated human plasma (2×) for three days induced mineralization and led to the formation of a hydroxyapatite-GelMA layer [82]. …”

Section: Hybrid Hydrogels Based On Gelmamentioning

confidence: 99%

“…Recent reports demonstrated promising applications of GelMA hydrogels for the fabrication of functional bone scaffolds (Figure 5E) [78, 81, 82]. Zuo et al .…”

Section: Biomedical Applications Of Gelma Hydrogelsmentioning

confidence: 99%

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Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

et al. 2015

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Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. Three dimensional (3D) GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties which mimic the native ECM. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental single-single cell research, cell signaling, drug and gene delivery, and bio-sensing.

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Section: Hybrid Hydrogels Based On Gelmamentioning

confidence: 99%

Section: Hybrid Hydrogels Based On Gelmamentioning

confidence: 99%

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Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

et al. 2015

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“…1, 10 As a result, reinforcement of GelMA is desirable for many applications. 11 Mineralized GelMA hydrogel with either Ca 2+ binding-carboxyl groups 12 or titanium 13 have improved modulus for tissue repair. The elastic modulus of soft GelMA hydrogels increases from 10 KPa to 24KPa by incorporating dextran glycidyl methacrylate upon photocrosslinking, 14 and to 50 KPa upon reinforcement with aligned carbon nanotubes.…”

mentioning

confidence: 99%

Ultrastrong and flexible hybrid hydrogels based on solution self-assembly of chitin nanofibers in gelatin methacryloyl (GelMA)

et al. 2016

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“…Therefore, a variety of techniques have been developed to toughen hydrogel implant interfaces . Siloxane covalent chemistry have been extensively studied to achieve tough bonding by chemically anchoring the cross‐linked networks on the functional silane layers of the implant surfaces . For example, grafted 3‐(trimethoxysilyl) propyl methacrylate (TMSPMA) has a methacrylate terminal group which can copolymerize with the acrylate groups‐containing hydrogel under a free radical polymerization process, generating chemically anchored hydrogels onto various implant surfaces .…”

Section: Introductionmentioning

confidence: 99%

Covalent Bonding of an Electroconductive Hydrogel to Gold‐Coated Titanium Surfaces via Thiol‐ene Click Chemistry

Tan

Liu

Zhou

et al. 2016

Macro Materials & Eng

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In the present study, the covalent bonding of electroconductive cross‐linked hydrogel networks with both electro‐properties and hydrogel characteristics to titanium surfaces via a UV‐initiated radical thiol‐ene click reaction is investigated. The electroconductive hydrogel layers are formed by the electropolymerization of pyrrole within the titanium implant‐supported gelatin methacrylate hydrogel. Characterization of the surface morphology of the layers reveals a unique rough macroporous structure. The hydrogel coating layer on the titanium surfaces possesses the desired characteristics of high electrochemical activity and high mechanical stability due to the effects of the chemical functionalization. Bone mesenchymal stem cells cultured on the hydrogel substrates exhibit high cell viability. This study is the first to demonstrate the potential of an electroconductive hydrogel as a surface coating on titanium implants for cell growth and provides a foundation for the development of new implantable bioelectronic devices.

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Biomimetically-mineralized composite coatings on titanium functionalized with gelatin methacrylate hydrogels

Cited by 65 publications

References 34 publications

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Ultrastrong and flexible hybrid hydrogels based on solution self-assembly of chitin nanofibers in gelatin methacryloyl (GelMA)

Covalent Bonding of an Electroconductive Hydrogel to Gold‐Coated Titanium Surfaces via Thiol‐ene Click Chemistry

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