Biomimetic single-atom nanozyme system for efficient inhibition of gastric cancer ascites via SO2 gas-enhanced nanocatalytic cancer therapy

Chen, Tao; Luo, Xi; Zhu, Liwei; Xiang, Jingfeng; Fang, Chuanfa; Zhu, Delan; Li, Guoxin; Duo, Yanhong

doi:10.1016/j.cej.2023.143386

Cited by 11 publications

(9 citation statements)

References 60 publications

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“…Chen et al achieved in situ downregulation of GSH and upregulation of H 2 O 2 to enhance the catalytic ability of SANZs. 16 Insufficient hydrogen ions in the cells also limit SANZs therapeutic effects. 17−19 Zhu et al significantly increased the catalytic capacity of SANZs by simultaneously regulating hydrogen ions, GSH, and H 2 O 2 content in the cells to achieve self-enhanced POD-mimicking activity.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, recent studies have shown that depletion GSH through various mechanisms may be a viable approach to enhance the therapeutic efficacy of CDT. Chen et al achieved in situ downregulation of GSH and upregulation of H 2 O 2 to enhance the catalytic ability of SANZs . Insufficient hydrogen ions in the cells also limit SANZs therapeutic effects. − Zhu et al significantly increased the catalytic capacity of SANZs by simultaneously regulating hydrogen ions, GSH, and H 2 O 2 content in the cells to achieve self-enhanced POD-mimicking activity. , Overall, it is crucial for SANZs to realize the self-supply of H 2 O 2 and consumption of GSH at the infected site to reduce the toxicity of side effects, improve the catalytic therapeutic efficiency, and subsequently promote chronic wound healing.…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Pd Single-Atom Nanozyme for Enhanced Cascade Chemodynamic Therapy of Chronic Wounds

Xu,

Zhang,

Wang

et al. 2024

ACS Appl. Nano Mater.

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Nanozymes are considered promising therapeutic agents for infected chronic wounds due to their enzyme-like activity-mediated chemodynamic therapy (CDT). However, they still suffer from low catalytic efficiency and incapacity to address excessive glucose and heightened inflammatory responses in chronic wounds. Herein, we bound Pd sites to CeO 2 nanosheets in atomically dispersed form by high-temperature calcination, followed by loading glucose oxidase (GOx) to obtain Pd−CeO 2 @GOx singleatom nanozymes (SANZs) for enhanced cascade CDT of chronic wounds. Specifically, highly endogenous glucose first activates the catalytic activity of GOx for in situ self-supplement of H 2 O 2 and protons. Then, in an acidic microenvironment, the Pd single atoms exert efficient glutathione peroxidase (GSH-Px) mimicking to amplify peroxidase (POD)-mimicking activity, generating burst • OH to eradicate Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus pathogens and suppress biofilm formation. Finally, Pd sites promote the catalase (CAT)-mimicking activity of CeO 2 carriers to convert the remaining H 2 O 2 to O 2 , which relieves inflammatory responses and contributes to blood vessel reconstruction in wounds. This cascade CDT strategy by Pd−CeO 2 @GOx SANZs could accelerate the healing of chronic wounds within 17 days. Therefore, this study opens up insights into the rational design of multienzyme active SANZs for the therapy of chronic wounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multifunctional Pd Single-Atom Nanozyme for Enhanced Cascade Chemodynamic Therapy of Chronic Wounds

Xu,

Zhang,

Wang

et al. 2024

ACS Appl. Nano Mater.

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“…[24][25][26] Recently, more and more studies have revealed that SO 2 shows intriguing potential in fighting a variety of diseases, including cardiovascular system dysregulation, 27,28 inflammation, 29,30 and cancers. [31][32][33] SO 2 is reported to be a systemic oxidative damage agent. It may cause toxicological damage to multiple organs of animals, which might result in a significant elevation in the lipid peroxidation (LPO) in all organs 34 and contribute to the oxidative stress-induced damage of biomacromolecules (e.g., lipids, proteins, and DNAs).…”

Section: Introductionmentioning

confidence: 99%

Glutathione-triggered release of SO₂ gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Tian,

Li,

Wang

et al. 2024

Biomater. Sci.

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“…This results in a short blood circulation time that considerably hampers their effectiveness. In addition, as nanomaterials lack active targeting abilities, they are widely distributed throughout the body can easily cause systemic toxicity., 33 Platelets are important circulating cells in the body that have been widely used in constructing bionic drug delivery systems. 27 , 33 , 34 Platelets have many advantages over other cells.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Copper-Doped Polypyrrole Nanoparticles for Enhanced Cancer Low-Temperature Photothermal Therapy

Chen,

Luo,

Cai

et al. 2023

IJN

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Introduction: Photothermal therapy (PTT) has a significant potential for its application in precision tumour therapy. However, PTTinduced hyperthermia may damage healthy tissues and trigger the expression of heat shock proteins (HSPs), thereby compromising the long-term therapeutic efficacy of PTT. Methods: In this study, a biomimetic drug delivery system comprising CuP nanozymes as the inner core and platelet membrane (PM) as the outer shell was successfully developed for administering synergistic chemodynamic therapy and mild PTT. PM is encapsulated on CuP to form this biomimetic nanoparticle (PM-coated CuP nanoparticles, PC). PC possesses peroxidase (POD) activity, can facilitate the conversion of hydrogen peroxide into •OH, thereby inhibiting the expression of HSPs. Results: Upon exposure to low-power laser irradiation (0.5 W/cm 2 , 1064 nm), PC can convert near-infrared II laser energy into heat energy, thereby enabling the administration of enhanced mild PTT. In vitro and in vivo experiments have demonstrated that this synergistic approach can induce over 90% tumour eradication with favourable biocompatibility. Discussion: PC exhibits high efficacy and biocompatibility, making it a promising candidate for future applications.

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Biomimetic single-atom nanozyme system for efficient inhibition of gastric cancer ascites via SO2 gas-enhanced nanocatalytic cancer therapy

Cited by 11 publications

References 60 publications

Multifunctional Pd Single-Atom Nanozyme for Enhanced Cascade Chemodynamic Therapy of Chronic Wounds

Multifunctional Pd Single-Atom Nanozyme for Enhanced Cascade Chemodynamic Therapy of Chronic Wounds

Glutathione-triggered release of SO₂ gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Biomimetic Copper-Doped Polypyrrole Nanoparticles for Enhanced Cancer Low-Temperature Photothermal Therapy

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Biomimetic single-atom nanozyme system for efficient inhibition of gastric cancer ascites via SO2 gas-enhanced nanocatalytic cancer therapy

Cited by 11 publications

References 60 publications

Multifunctional Pd Single-Atom Nanozyme for Enhanced Cascade Chemodynamic Therapy of Chronic Wounds

Multifunctional Pd Single-Atom Nanozyme for Enhanced Cascade Chemodynamic Therapy of Chronic Wounds

Glutathione-triggered release of SO2 gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Biomimetic Copper-Doped Polypyrrole Nanoparticles for Enhanced Cancer Low-Temperature Photothermal Therapy

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Glutathione-triggered release of SO₂ gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy