Glutathione-triggered release of SO<sub>2</sub> gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Tian, Ya; Li, Pei; Wang, Likai; Ye, Xueli; Qu, Zhonghuan; Mou, Juan; Yang, Shiping; Wu, Huixia

doi:10.1039/d3bm02027d

Biomater. Sci.

2024

DOI: 10.1039/d3bm02027d

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Glutathione-triggered release of SO₂ gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Ya Tian,

Pei Li,

Likai Wang

et al.

Abstract: Recently, gas therapy has emerged as a promising alternative treatment for deep-seated tumors. However, some challenges regarding insufficient or uncontrolled gas generation as well as unclear therapeutic mechanisms, restrict its...

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Zhang,

Sun,

Huang

et al. 2024

Advanced Materials

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Low‐intensity ultrasound‐mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety of diseases. Nanoscale sonosensitizers play a crucial role in the SDT process because their structural, compositional, physicochemical, and biological characteristics are key determinants of therapeutic efficacy. In particular, advances in materials science and nanotechnology have invigorated a series of optimization strategies for augmenting the therapeutic efficacy of nanosonosensitizers. This comprehensive review systematically summarizes, discusses, and highlights state‐of‐the‐art studies on the current achievements of nanosonosensitizer optimization in enhanced sonodynamic disease treatment, with an emphasis on the general design principles of nanosonosensitizers and their optimization strategies, mainly including organic and inorganic nanosonosensitizers. Additionally, recent advancements in optimized nanosonosensitizers for therapeutic applications aimed at treating various diseases, such as cancer, bacterial infections, atherosclerosis, and autoimmune diseases, are clarified in detail. Furthermore, the biological effects of the improved nanosonosensitizers for versatile SDT applications are thoroughly discussed. The review concludes by highlighting the current challenges and future opportunities in this rapidly evolving research field to expedite its practical clinical translation and application.

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Zhang,

Sun,

Huang

et al. 2024

Advanced Materials

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Fenton-like nanoparticles capable of H₂O₂ self-supply and glutathione consumption for chemodynamic and chemotherapy of cancer

He,

Tian,

Zhang

et al. 2024

Biomater. Sci.

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Glutathione-triggered release of SO₂ gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Abstract: Recently, gas therapy has emerged as a promising alternative treatment for deep-seated tumors. However, some challenges regarding insufficient or uncontrolled gas generation as well as unclear therapeutic mechanisms, restrict its...

Cited by 2 publications

References 50 publications

Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Fenton-like nanoparticles capable of H₂O₂ self-supply and glutathione consumption for chemodynamic and chemotherapy of cancer

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Glutathione-triggered release of SO2 gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Abstract: Recently, gas therapy has emerged as a promising alternative treatment for deep-seated tumors. However, some challenges regarding insufficient or uncontrolled gas generation as well as unclear therapeutic mechanisms, restrict its...

Cited by 2 publications

References 50 publications

Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Fenton-like nanoparticles capable of H2O2 self-supply and glutathione consumption for chemodynamic and chemotherapy of cancer

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Glutathione-triggered release of SO₂ gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Fenton-like nanoparticles capable of H₂O₂ self-supply and glutathione consumption for chemodynamic and chemotherapy of cancer