Biomimetic remineralization of artificial caries dentin lesion using Ca/P-PILP

Chen, Ruitian; Jin, Runze; Li, Xin; Fang, Xiaolin; Yuan, Ding; Chen, Zhuo; Yao, Shasha; Tang, Ruikang; Chen, Zhi

doi:10.1016/j.dental.2020.08.017

Cited by 28 publications

(29 citation statements)

References 37 publications

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“…Dental caries is a dynamic of pathological demineralization and physiological remineralization of teeth (17) . By regulating the mineral balance favourably towards the remineralization, the caries lesion can be arrested or repaired.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Remineralizing Potential of Cranberry and Chitosan on Demineralized Dentin (An in Vitro Study)

2022

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Section: Discussionmentioning

confidence: 99%

Evaluation of Remineralizing Potential of Cranberry and Chitosan on Demineralized Dentin (An in Vitro Study)

2022

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“…Intrafibrillar mineralized collagen was also thought to promote bone regeneration via activation of the Wnt signaling pathway [ 93 ]. The acceleration of dentin remineralization through various biomimetic strategies have also been reported recently to be an effective approach for tooth defect repair [ 94 , 95 , 96 , 97 ]. In this section, typical strategies for biomimetic synthesis of intrafibrillar mineralized collagen-based materials are included.…”

Section: Biomimetic Intrafibrillar Mineralization Strategies For Hmentioning

confidence: 99%

Biomineralization of Collagen-Based Materials for Hard Tissue Repair

Wei

2021

IJMS

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Hydroxyapatite (HA) reinforced collagen fibrils serve as the basic building blocks of natural bone and dentin. Mineralization of collagen fibrils play an essential role in ensuring the structural and mechanical functionalities of hard tissues such as bone and dentin. Biomineralization of collagen can be divided into intrafibrillar and extrafibrillar mineralization in terms of HA distribution relative to collagen fibrils. Intrafibrillar mineralization is termed when HA minerals are incorporated within the gap zone of collagen fibrils, while extrafibrillar mineralization refers to the minerals that are formed on the surface of collagen fibrils. However, the mechanisms resulting in these two types of mineralization still remain debatable. In this review, the evolution of both classical and non-classical biomineralization theories is summarized. Different intrafibrillar mineralization mechanisms, including polymer induced liquid precursor (PILP), capillary action, electrostatic attraction, size exclusion, Gibbs-Donnan equilibrium, and interfacial energy guided theories, are discussed. Exemplary strategies to induce biomimetic intrafibrillar mineralization using non-collagenous proteins (NCPs), polymer analogs, small molecules, and fluidic shear stress are discussed, and recent applications of mineralized collagen fibers for bone regeneration and dentin repair are included. Finally, conclusions are drawn on these proposed mechanisms, and the future trend of collagen-based materials for bone regeneration and tooth repair is speculated.

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“…Based on this pioneering study, later studies have exploited the concept of ACP precursors stabilized by anionic polyelectrolytes for remineralization of dentin. 177 – 180 The most frequently used anionic polyelectrolytes are PAsp and PAA. For instance, Marshall et al 177 applied the PILP system induced by PAsp on partially demineralized dentin, and recovered the mechanical properties with progressive intra- and extra-fibrillar mineralization.…”

Section: Dentin Remineralizationmentioning

confidence: 99%

Advances in biomineralization-inspired materials for hard tissue repair

Tang

Dong

et al. 2021

Int J Oral Sci

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Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties, including the bones and teeth in vertebrates. The underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard tissues. In particular, the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in biomineralization. Here, we review recent advances in biomineralization-inspired materials developed for hard tissue repair. Biomineralization-inspired materials are categorized into different types based on their specific applications, which include bone repair, dentin remineralization, and enamel remineralization. Finally, the advantages and limitations of these materials are summarized, and several perspectives on future directions are discussed.

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Biomimetic remineralization of artificial caries dentin lesion using Ca/P-PILP

Cited by 28 publications

References 37 publications

Evaluation of Remineralizing Potential of Cranberry and Chitosan on Demineralized Dentin (An in Vitro Study)

Evaluation of Remineralizing Potential of Cranberry and Chitosan on Demineralized Dentin (An in Vitro Study)

Biomineralization of Collagen-Based Materials for Hard Tissue Repair

Advances in biomineralization-inspired materials for hard tissue repair

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