Biomimetic poly(glycerol sebacate)/polycaprolactone blend scaffolds for cartilage tissue engineering

Liu, Yadong; Tian, Kui; Hao, Jun; Yang, Tao; Geng, Xiaoling; Zhang, Weiguo

doi:10.1007/s10856-019-6257-3

Cited by 33 publications

(22 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poly(glycerol-sebacate) (PGS), a biocompatible and biodegradable soft elastomer first introduced by Wang and co-workers [6], has recently attracted much attention since its properties appeared to be particularly interesting for regenerative medicine. PGS has been studied for a broad range of applications including cardiovascular patches [7,8], heart valves [9], as well as for cartilage [10,11], bone [12], corneal [13] and nerve [14,15] tissue engineering, for the retina [16,17] and tympanic membrane healing [18,19]. Synthesis of PGS involves a two-step procedure: First, the PGS pre-polymer (PGS p ) is synthesized from pre-polycondensation of glycerol and sebacic acid, then the cross-linked polymer can be obtained by additional vacuum heat treatment of the PGS p precursor.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

et al. 2020

View full text Add to dashboard Cite

Poly(glycerol-sebacate) (PGS) and poly(epsilon caprolactone) (PCL) have been widely investigated for biomedical applications in combination with the electrospinning process. Among others, one advantage of this blend is its suitability to be processed with benign solvents for electrospinning. In this work, the suitability of PGS/PCL polymers for the fabrication of composite fibers incorporating bioactive glass (BG) particles was investigated. Composite electrospun fibers containing silicate or borosilicate glass particles (13-93 and 13-93BS, respectively) were obtained and characterized. Neat PCL and PCL composite electrospun fibers were used as control to investigate the possible effect of the presence of PGS and the influence of the bioactive glass particles. In fact, with the addition of PGS an increase in the average fiber diameter was observed, while in all the composite fibers, the presence of BG particles induced an increase in the fiber diameter distribution, without changing significantly the average fiber diameter. Results confirmed that the blended fibers are hydrophilic, while the addition of BG particles does not affect fiber wettability. Degradation test and acellular bioactivity test highlight the release of the BG particles from all composite fibers, relevant for all applications related to therapeutic ion release, i.e., wound healing. Because of weak interface between the incorporated BG particles and the polymeric fibers, mechanical properties were not improved in the composite fibers. Promising results were obtained from preliminary biological tests for potential use of the developed mats for soft tissue engineering applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A similar pattern is seen in the pPGS group (Figure 5B, Table S3), where the samples with the lower PCL ratios presented higher degrees of degradation. This is supported by Liu et al's findings of the PCL's slower degradation rate compared to PGS [43]. Therefore, by using the two variant forms of PGS, and by adjusting its ratio within the polymer blends, it can help control, to a certain extent, the degradation of the composite electrospun mats.…”

Section: Influence Of Pgs In the Degradation Properties Of The Electrospun Matsmentioning

confidence: 60%

High-throughput production of silk fibroin-based electrospun fibers as biomaterial for skin tissue engineering applications

Keirouz

Zakharova

Kwon

et al. 2020

Materials Science and Engineering: C

View full text Add to dashboard Cite

In this work, a nozzle-free electrospinning device was developed to obtain high-throughput production of silk fibroin-based trinary biocompatible composite fibers with tunable wettability. Synthetic fiber materials tend to present suboptimal cell growth and proliferation, with many studies linking this phenomenon to the hydrophobicity of such surfaces. In this study, electrospun mats consisting of Poly(caprolactone) blended with variant forms of Poly(glycerol sebacate) and regenerated silk fibroin were fabricated. The main aim of this work was the development of fiber mats with tunable hydrophobicity/hydrophilicity properties depending on the variant curing forms and concentration of PGS. A variation of the conventional protocol used for the extraction of silk fibroin from Bombyx mori cocoons was employed, achieving significantly increased yields of the protein, in a third of the time required via the conventional protocol. The wettability of the scaffolds could be modulated varying the ratios and curing time of the PGS within the composite fibers. The trinary composite biomaterial presented good in vitro fibroblast attachment behavior and optimal growth, indicating the potential of such constructs towards the development of an artificial skin-like platform that can aid skin regeneration.

show abstract

“…Poly(glycerol sebacate) (PGS) is a representative synthetic bioelastomer with the characteristics of controllable degradation, high plasticity, and excellent biocompatibility. Therefore, PGS has been widely used in a variety of biomedical applications, especially for soft tissue regeneration [ 99 ]. One of its most important features is robust elasticity, which enables it to easily sustain and restore various deformations in soft tissues and in dynamic mechanical environments, without mechanical irritations to the surroundings.…”

Section: Application Of Other Scaffold Materials In Endometrial Regenerative Medicinementioning

confidence: 99%

Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration

Zhao

et al. 2021

Materials Today Bio

View full text Add to dashboard Cite

Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may lead to uterine infertility, recurrent miscarriage, abnormal menstrual bleeding, and other obstetric complications. It is a pressing public health issue among women of childbearing age. Presently, there are limited clinical treatments for IUA, and there is no sufficient evidence that these treatment modalities can effectively promote regeneration after severe endometrial injury or improve pregnancy outcome. The inhibitory pathological micro-environment is the main factor hindering the repair of endometrial damaged tissues. To address this, tissue engineering and regenerative medicine have been achieving promising developments. Particularly, biomaterials have been used to load stem cells or therapeutic factors or construct an in situ delivery system as a treatment strategy for endometrial injury repair. This article comprehensively discusses the characteristics of various bio-scaffold materials and their application as stem cell or therapeutic factor delivery systems constructed for uterine tissue regeneration.

show abstract

Biomimetic poly(glycerol sebacate)/polycaprolactone blend scaffolds for cartilage tissue engineering

Cited by 33 publications

References 30 publications

Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

High-throughput production of silk fibroin-based electrospun fibers as biomaterial for skin tissue engineering applications

Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration

Contact Info

Product

Resources

About