This review provides insights into the current advancements in the field of electrospinning, focusing on its applications for skin tissue engineering. Furthermore, it reports the evolvement and present challenges of advanced skin substitute product development and explores the recent contributions in 2D and 3D scaffolding, focusing on natural, synthetic, and composite nanomaterials. In the past decades, nanotechnology has arisen as a fascinating discipline that has influenced every aspect of science, engineering, and medicine. Electrospinning is a versatile fabrication method that allows researchers to elicit and explore many of the current challenges faced by tissue engineering and regenerative medicine. In skin tissue engineering, electrospun nanofibers are particularly attractive due to their refined morphology, processing flexibility—that allows for the formation of unique materials and structures, and its extracellular matrix‐like biomimetic architecture. These allow for electrospun nanofibers to promote improved re‐epithelization and neo‐tissue formation of wounds. Advancements in the use of portable electrospinning equipment and the employment of electrospinning for transdermal drug delivery and melanoma treatment are additionally explored. Present trends and issues are critically discussed based on recently published patents, clinical trials, and in vivo studies. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanomaterials and Implants

The cover image is based on the Advanced Review 2D and 3D electrospinning technologies for the fabrication of nanofibrous scaffolds for skin tissue engineering: A review, by Antonios Keirouz, Michael Chung, Jaehoon Kwon, Giuseppino Fortunato and Norbert Radacsi. https://doi.org/10.1002/wnan.1626.

In this work, a nozzle-free electrospinning device was developed to obtain high-throughput production of silk fibroin-based trinary biocompatible composite fibers with tunable wettability. Synthetic fiber materials tend to present suboptimal cell growth and proliferation, with many studies linking this phenomenon to the hydrophobicity of such surfaces. In this study, electrospun mats consisting of Poly(caprolactone) blended with variant forms of Poly(glycerol sebacate) and regenerated silk fibroin were fabricated. The main aim of this work was the development of fiber mats with tunable hydrophobicity/hydrophilicity properties depending on the variant curing forms and concentration of PGS. A variation of the conventional protocol used for the extraction of silk fibroin from Bombyx mori cocoons was employed, achieving significantly increased yields of the protein, in a third of the time required via the conventional protocol. The wettability of the scaffolds could be modulated varying the ratios and curing time of the PGS within the composite fibers. The trinary composite biomaterial presented good in vitro fibroblast attachment behavior and optimal growth, indicating the potential of such constructs towards the development of an artificial skin-like platform that can aid skin regeneration.

-According to the manufacturing process of the laminated stator core for an inserted permanent magnet synchronous motor (IPMSM), the iron loss may be different. It is because the mechanical stress imposed to electrical steel sheet is strongly dependent on the manufacturing process. This paper proposes a new iron loss measurement algorithm which utilizes the induced voltage of a search coil and exciting current. The method is effective even when the distribution of magnetic flux density is not uniform along the magnetic flux path as well as uniform. The developed iron loss measurement system is applied to bonded-and embossed-type segmented stator cores of an IPMSM, and the iron losses are quantitatively compared.