Biomimetic norfloxacin sensors made of molecularly-imprinted materials for potentiometric transduction

Moreira, Felismina T.C.; Freitas, Víctor de; Sales, M. Goreti F.

doi:10.1007/s00604-010-0464-4

Cited by 27 publications

(9 citation statements)

References 31 publications

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“…Where Q is the binding capacity of the polymer in (μM/g), C i is the initial VCV concentration in (μM/mL), C f is the final free VCV concentration at equilibrium in (μM/mL), V s is the volume of sample solution tested (mL) and M is the mass of polymer used in (mg) ; the imprinting factor (IF) was calculated as;

true IF = normalQ_{MIP} / normalQ_{NIP}

…”

Section: Methodsmentioning

confidence: 99%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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A molecularly imprinted polymer (MIP) was rationally synthesized with the aid of computer based studies. The computational studies were used to screen for the most suitable template to functional monomer molar ratio. Two functional monomers were involved in the study (methacrylic acid and 4‐vinylpyridine). Four MIP ratios were synthesized in accordance with the results of the computational studies and their performance was evaluated using equilibrium rebinding assays. The MIP with the best performance was used as an additive in carbon paste electrodes for the voltammetric determination of valaciclovir (VCV). Following the optimization of voltammetric parameters, a linear response was obtained in the range of 1.0x10−6–7.0x10−4 M with a limit of detection at 4.45x10−7 M. The MIP modified carbon paste electrode was successfully applied for the determination of VCV in pure solutions and dosage form.

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true IF = normalQ_{MIP} / normalQ_{NIP}

…”

Section: Methodsmentioning

confidence: 99%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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“…The comparison of this work with others (Agrawal et al, 2013;Devaraj, Deivasigamani, Jeyadevan, 2013;Moreira, Freitas, Sales, 2011) showed the advantage of GO added. This research demonstrate again that GO is an excellent modification material in voltammetric sensor.…”

Section: Calibration Curve Stability and Reproducibilitymentioning

confidence: 98%

“…By comparison, electrochemical method is less expensive and has additional advantages, such as fast response speed, simple operation, timesaving, high sensitivity, and real-time detection in clinical and drug control. Based on these reasons, some electrochemical methods for determination of NFX were developed more recently (Agrawal et al, 2013;Devaraj, Deivasigamani, Jeyadevan, 2013;Moreira, Freitas, Sales, 2011). Shim and co-workers (Agrawal et al, 2013) used a multi-walled carbon nanotube (MWCNT) modified pyrolytic graphite (MPG) electrode for determination of NFX.…”

Section: Inroductionmentioning

confidence: 99%

A simple and sensitive method for determination of Norfloxacin in pharmaceutical preparations

Wang

Wen

2015

Braz. J. Pharm. Sci.

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In this approach, a new voltammetric method for determination of norfloxacin was proposed with high sensitivity and wider detection linear range. The used voltammetric sensor was fabricated simply by coating a layer of graphene oxide (GO) and Nafion composited film on glassy carbon electrode. The advantage of proposed method was sensitive electrochemical response for norfloxacin, which was attributed to the excellent electrical conductivity of GO and the accumulating function of Nafion under optimum experimental conditions, the present method revealed a good linear response for determination of norfloxacin in the range of 1×10-8 mol/L-7×10 -6 mol/L with a detection limit of 5×10 -9 mol/L. The proposed method was successfully applied in the determination of norfloxacin in capsules with satisfactory results.Uniterms: Norfloxacin/determination. Graphene oxide. Nafion. Voltammetry/differential pulse. Pharmaceutical formulations/quantitative analysis.Propos-se, por essa abordagem, novo método voltamétrico, com alta sensibilidade e faixa linear de detecção mais ampla, para a determinação de norfloxacino. O sensor voltamétrico utilizado foi fabricado simplismente por cobertura de camada de óxido de grafeno (GO) e filme de Nafion em eletrodo de cabrono vítreo. A vantagem do método proposto foi a resposta eletroquímica sensível para o norfloxacino, atribuída à condutividade elétrica excelente do GO e à função acumulada do Nafion. Sob condições experimentais ótimas, o presente método revelou boa resposta linear para a determinação do norfloxacino na faixa de limite de detecção de 1×10 -8 mol/L-7×10 -6 mol/L. O método proposto foi aplicado com sucesso na determinação de norfloxacino em cápsulas, com resultados satisfatórios.Uniterms: Norfloxacino/determinação. Óxido de grafeno. Nafion. Voltametria de pulso diferencial. Formulações farmacêuticas/análise quantitativa.

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“…Finally, in [288], an approach based on host-guest interaction in molecularly imprinted materials was developed, characterised and successfully applied to the sensing of norflaxin. Polymers were used made from methacrylic acid and/or 2-vinyl pyridine.…”

Section: Potentiometric Sensors Containing New Ion-exchange Componentsmentioning

confidence: 99%

Bioelectroanalysis of pharmaceutical compounds

et al. 2012

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Recent developments in the bioelectroanalysis of pharmaceutical compounds are reviewed, concentrating particularly on the development of electrode materials and measurement strategies and on their application. The advantages of electroanalytical techniques as alternatives to other analytical procedures such as rapid response, sensitivity and low detection limits are highlighted and illustrated. Particular emphasis is given to carbon-based materials for voltammetric electroanalysis; new potentiometric sensors and electrochemical biosensors are also reviewed.

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Biomimetic norfloxacin sensors made of molecularly-imprinted materials for potentiometric transduction

Cited by 27 publications

References 31 publications

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

A simple and sensitive method for determination of Norfloxacin in pharmaceutical preparations

Bioelectroanalysis of pharmaceutical compounds

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