Biomimetic Nanomaterials from the Assembly of Polymers, Lipids, and Surfactants

Carmona-Ribeiro, Ana Maria

doi:10.5772/intechopen.84618

Cited by 12 publications

(26 citation statements)

References 92 publications

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“…In addition, colloidal NPs of biodegradable chitosan, lignin or dextran [5,6] or biocompatible poly (methacrylate)-and poly (acrylate)-based copolymers can be loaded with antibacterial agents [7]. The other class of hybrid nanomaterials encompasses the biomimetic antimicrobial NPs and coatings obtained from the assembly of polymers, surfactants, or lipids [8,9] or from the use of virus-like, bacteria-like, or biological structure-like nanomaterials carrying antimicrobials [10].…”

Section: Introductionmentioning

confidence: 99%

Microbicidal Dispersions and Coatings from Hybrid Nanoparticles of Poly (Methyl Methacrylate), Poly (Diallyl Dimethyl Ammonium) Chloride, Lipids, and Surfactants

Ribeiro

Galvão

Betancourt

et al. 2019

IJMS

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Hybrid and antimicrobial nanoparticles (NPs) of poly (methyl methacrylate) (PMMA) in the presence of poly (diallyl dimethyl ammonium) chloride (PDDA) were previously obtained by emulsion polymerization in absence of surfactant with low conversion. In the presence of amphiphiles such as cetyl trimethyl ammonium bromide (CTAB), dioctadecyl dimethyl ammonium bromide (DODAB) or soybean lecithin, we found that conversion increased substantially. In this work, the effect of the amphiphiles on the NPs core-shell structure and on the antimicrobial activity of the NPs was evaluated. NPs dispersions casted on silicon wafers, glass coverslips or polystyrene substrates were also used to obtain antimicrobial coatings. Methods for characterizing the dispersions and coatings were based on scanning electron microscopy, dynamic light scattering, determination of thickness, rugosity, and wettability for the coatings and determination of colony-forming unities (log CFU/mL) of microbia after 1 h interaction with the coatings or dispersions. The amphiphiles used during PMMA/PDDA/amphiphile NPs synthesis reduced the thickness of the NPs PDDA shell surrounding each particle. The antimicrobial activity of the dispersions and coatings were due to PDDA—the amphiphiles were either washed out by dialysis or remained in the PMMA polymeric core of the NPs. The most active NPs and coatings were those of PMMA/PDDA/CTAB—the corresponding coatings showed the highest rugosity and total surface area to interact with the microbes. The dispersions and coatings obtained by casting of the NPs dispersions onto silicon wafers were hydrophilic and exhibited microbicidal activity against Escherichia coli, Staphylococcus aureus, and Candida albicans. In addition, a major effect of reduction in particle size revealed the suitability of nanometric and cationic NPs (sizes below 100 nm) represented by PMMA/PDDA/CTAB NPs to yield maximal microbicidal activity from films and dispersions against all microbia tested. The reduction of cell viability by coatings and dispersions amounted to 6–8 logs from [PDDA] ≥ minimal microbicidal concentration.

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Section: Introductionmentioning

confidence: 99%

Microbicidal Dispersions and Coatings from Hybrid Nanoparticles of Poly (Methyl Methacrylate), Poly (Diallyl Dimethyl Ammonium) Chloride, Lipids, and Surfactants

Ribeiro

Galvão

Betancourt

et al. 2019

IJMS

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“…In another instance, DODAB cationic bilayer surrounded polystyrene sulfate particles available over a range of diameters [ 205 , 206 , 207 ] or silica particles [ 208 , 209 ]; recently optimal coverage with single cationic bilayers on the anionic polymeric or inorganic particles was achieved [ 207 , 209 ]. Synthetic biocompatible polymers such as PMMA were also hybridized with cationic polymers or cationic lipids or surfactants [ 160 , 161 , 162 , 163 , 210 , 211 , 212 , 213 ]. In summary, a variety of model hybrid and cationic delivery systems are already available to combine with a myriad of oppositely charged antigens for vaccine design [ 25 , 163 , 214 , 215 ].…”

Section: Hybrid Cationic Assemblies Of Biocompatible Polymer/catiomentioning

confidence: 99%

“…Non-covalent nanoparticle (NP) assemblies of PMMA, a synthetic, non-charged, and biocompatible polymer, and PDDA polycation have been described earlier by our group since the first report on the good compatibility and miscibility of PDDA with PMMA evaluated from microbicidal PMMA/PDDA NPs [ 160 , 161 , 162 , 163 , 210 , 211 , 212 , 213 , 214 ]. The synthesis of PMMA NPs by emulsion polymerization of MMA in the presence of PDDA yielded cationic, homodisperse, and stable NPs [ 160 , 212 ], which are presently being evaluated in our group for possible applications as immunoadjuvants.…”

Section: Hybrid Cationic Assemblies Of Biocompatible Polymer/catiomentioning

confidence: 99%

Cationic Nanostructures for Vaccines Design

Carmona-Ribeiro

Betancourt

2020

Biomimetics

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Subunit vaccines rely on adjuvants carrying one or a few molecular antigens from the pathogen in order to guarantee an improved immune response. However, to be effective, the vaccine formulation usually consists of several components: an antigen carrier, the antigen, a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a stimulator of humoral response such as an inflammasome activator. Most antigens are negatively charged and combine well with oppositely charged adjuvants. This explains the paramount importance of studying a variety of cationic supramolecular assemblies aiming at the optimal activity in vivo associated with adjuvant simplicity, positive charge, nanometric size, and colloidal stability. In this review, we discuss the use of several antigen/adjuvant cationic combinations. The discussion involves antigen assembled to 1) cationic lipids, 2) cationic polymers, 3) cationic lipid/polymer nanostructures, and 4) cationic polymer/biocompatible polymer nanostructures. Some of these cationic assemblies revealed good yet poorly explored perspectives as general adjuvants for vaccine design.

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“…The major advantage in polymer and lipid-based drug carrier systems is increased bioavailability in patients. Targeted therapy is more efficient through lipid and polymer-based carrier systems, due to which the bioavailability is increased and therapy is escalated [59] [60].…”

Section: Clinician's Perspective In Prescribing Marketed Lipid/polymementioning

confidence: 99%

Understanding Novel Polymer and Lipid Based Carrier Systems in Clinician Perspective

Reddy¹

2020

ijmsdr

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From the past two decades, technological advancements in science and chemistry made possible many new drug delivery systems that have the potential to completely change the course of routine therapeutic ways. Lipid and polymer-based drug delivery systems are considered to be the pillars of many drug dosage forms, irrespective of their route of administration. With increasing knowledge on their chemistry, lipids and polymers are being modified and used as potential novel drug delivery systems with smart polymers and lipid nanotechnology paving the way for efficient drug delivery into the patient. This review article covers the swing of these drug delivery systems in the current market and interpreting all this from a health care professional’s point of view. Keywords: Gene delivery, Lipid based drug delivery, Polymer based drug delivery, Target specific drugs, Solid lipid nanoparticles

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Biomimetic Nanomaterials from the Assembly of Polymers, Lipids, and Surfactants

Cited by 12 publications

References 92 publications

Microbicidal Dispersions and Coatings from Hybrid Nanoparticles of Poly (Methyl Methacrylate), Poly (Diallyl Dimethyl Ammonium) Chloride, Lipids, and Surfactants

Microbicidal Dispersions and Coatings from Hybrid Nanoparticles of Poly (Methyl Methacrylate), Poly (Diallyl Dimethyl Ammonium) Chloride, Lipids, and Surfactants

Cationic Nanostructures for Vaccines Design

Understanding Novel Polymer and Lipid Based Carrier Systems in Clinician Perspective

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