Biomimetic nanocomposite scaffolds based on surface modified PCL-nanofibers containing curcumin embedded in chitosan/gelatin for skin regeneration

Ghaee, Azadeh; Bagheri‐Khoulenjani, Shadab; Afshar, Hamideh Amir; Bogheiri, Hamidreza

doi:10.1016/j.compositesb.2019.107339

Cited by 104 publications

(55 citation statements)

References 59 publications

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“…The porosity of the nanofibers ranged between 90.43% and 71.48% with a pore size of 101–256 μm suitable for skin regeneration. The nanofibers were biocompatible on L929 cells and promoted good cell attachment [ 121 ].…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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“…Such broad applications of BC are attributable to its striking physical and mechanical characters, including high purity, hydrophilicity, crystallinity, biocompatibility, ultrafine fiber diameter (20-100 nm), high water holding capacity, high mechanical properties, broad chemical and physical modifying ability, shapeability, and nano-scaled three-dimensional (3D) network structure [4]. Although numerous materials have been developed to make wound dressings [5][6][7][8][9][10], BC is also a suitable material for wound dressings since it can provide a moist environment which is beneficial for healing [11] and biodegradability is not mandatory in wound dressings. Although providing an effective biological barrier to the wound, the fact that BC has no antibacterial activity limits its applications in clinics.…”

Section: Introductionmentioning

confidence: 99%

Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose

Wan

Yang

Wang

et al. 2020

Composites Part B: Engineering

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While silver nanoparticles are widely used to endow materials with antibacterial activity, silver nanowires (AgNWs) have not attracted much attention. Herein, the composites of bacterial cellulose (BC) and AgNWs were prepared through a novel step-by-step in situ biosynthesis which retains the three-dimensional network of BC. The results of water vapor permeability, water uptake rate, and water retention rate showed that the BC/AgNW wound dressings could absorb wound skin exudates and maintain moisture environments. Furthermore, the BC/ AgNW dressings were robust and stretchable. More importantly, the BC/AgNW dressings exhibited sustained release of Ag +. The results from animal tests indicated that the BC/AgNW dressing with 38.4 wt% AgNWs exhibited higher expression levels of cytokeratin-10 and integrin-β4, greater proliferation of keratinocytes and formation of epithelial tissues and greatly improved skin regeneration over the bare BC. We propose that the integrated nanofibrous structure and the excellent and sustained antibacterial activity of AgNWs are responsible for the excellent in vivo wound healing ability and biocompatibility. These results suggest that the BC/AgNW composites have promising application as wound dressings.

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“…Among the various uses of chitosan, biologically related applications are of special relevance and currently a growing area of research. Chitosan is used in tissue engineering, the development of injectable hydrogels and wound healing as well as for implant materials [17][18][19][20][21][22]. In acidic conditions, chitosan has a positively charged structure.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Extraction from Goliathus orientalis Moser, 1909: Characterization and Comparison with Commercially Available Chitosan

et al. 2020

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Chitosan is a polymer obtained by deacetylation of chitin, and chitin is one of the major components of the arthropod cuticle. Chitin and chitosan are both polysaccharides and are considered to be an interesting class of biosourced materials. This is evident as chitosan has already demonstrated utility in various applications in both industrial and biomedical domains. In the present work, we study the possibility to extract chitin and prepare chitosan from the Goliath beetle Goliathus orientalis Moser. The presented work includes description of this process and observation of the macroscopic and microscopic variations that occur in the specimen during the treatment. The prepared chitosan is characterized and compared with commercially available chitosan using infrared and thermogravimetric analysis. The deacetylation degree of prepared chitosan is also evaluated and compared with commercially available shrimp chitosan.

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Biomimetic nanocomposite scaffolds based on surface modified PCL-nanofibers containing curcumin embedded in chitosan/gelatin for skin regeneration

Cited by 104 publications

References 59 publications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose

Chitosan Extraction from Goliathus orientalis Moser, 1909: Characterization and Comparison with Commercially Available Chitosan

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