Biomimetic hierarchical nanofibrous surfaces inspired by superhydrophobic lotus leaf structure for preventing tissue adhesions

Klíčová, Markéta; Oulehlová, Zuzana; Klápšťová, Andrea; Hejda, Matěj; Krejčík, Michal; Novák, Ondřej; Müllerová, Jana; Erben, Jakub; Rosendorf, Jáchym; Pálek, Richard; Liška, Václav; Fučíková, Anna; Chvojka, Jiří; Zvercova, Iveta; Horakova, Jana

doi:10.1016/j.matdes.2022.110661

Cited by 28 publications

(22 citation statements)

References 38 publications

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“…Compared to the blank group, the PCL-, DOX@BSA/PCL-, and PCL/MnO 2 -treated groups significantly suppressed adhesion degrees with different A se of 0.11 ± 0.04 cm 2 , 0.21 ± 0.05 cm 2 , and 0.11 ± 0.02 cm 2 , respectively. Such significantly declined A se in these groups was mainly attributed to virtue of hydrophobic surfaces, which obstructed contact between spinal tumor and epidermal tissue . Interestingly, an optimal antiadhesion effect with the lowest A se of 0.04 ± 0.02 cm 2 was presented for the electrospun DOX@BSA/PCL/MnO 2 nanofiber.…”

Section: Resultsmentioning

confidence: 99%

“…As expected, grading score of the DOX@BSA/PCL/MnO 2 -treated group was apparently lower than the other groups. On the whole, the hydrophobic electrospun DOX@BSA/PCL/MnO 2 nanofiber with efficient antiadhesion performance provided conditions for superior tumor-killing effect through inhibiting adhesion of bacteria onto damaged spinal tissue, reducing the aggregation of fibroblasts or/and tumor cells as well as preventing the deepening of the inflammation by varying macrophage polarization phenotype. ,,, …”

Section: Resultsmentioning

confidence: 99%

“…In contrast, spinal tumor and epidermal tissues in the group treated with the electrospun PCL and DOX@BSA/PCL/MnO 2 nanofibers were significantly separated, where the electrospun mats provided an extensive physical barrier for spinal tumor growth and progression. Additionally, hydrophobic characteristics of PCL chains and MnO 2 coating changed the surface roughness and wettability of the membrane, thus further reducing the adhesion of tumor cells onto epidermal tissues …”

Section: Resultsmentioning

confidence: 99%

“…Such significantly declined A se in these groups was mainly attributed to virtue of hydrophobic surfaces, which obstructed contact between spinal tumor and epidermal tissue. 63 Interestingly, an optimal antiadhesion effect with the lowest A se of 0.04 ± 0.02 cm 2 was presented for the electrospun DOX@BSA/PCL/MnO 2 nanofiber. According to the in vitro degradation and WCA experimental results, a slow degradation rate and hydrophobic surface property together endowed the membrane with outstanding antiadhesion behavior.…”

Section: Release Behaviors Of Electrospun Nanofibers In Vitromentioning

confidence: 89%

“…On the whole, the hydrophobic electrospun DOX@BSA/PCL/MnO 2 nanofiber with efficient antiadhesion performance provided conditions for superior tumor-killing effect through inhibiting adhesion of bacteria onto damaged spinal tissue, reducing the aggregation of fibroblasts or/and tumor cells as well as preventing the deepening of the inflammation by varying macrophage polarization phenotype. 14,15,63,64 It has been widely accepted that regenerated collagen deposited on the wound easily resulted in the formation of mutual adhesion between spinal tumor and epidermal tissue after surgery. 65,66 As illustrated in Figure 5d, representative histological tissue sections at adhesion sites were chosen for hematoxylin and eosin (H&E) and Masson trichrome stainings.…”

Section: Release Behaviors Of Electrospun Nanofibers In Vitromentioning

confidence: 99%

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Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Qian

et al. 2022

ACS Nano

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Most treatments for spinal cancer are accompanied by serious side effects including subsequent tumor recurrence, spinal cord compression, and tissue adhesion, thus a highly effective treatment is crucial for preserving spinal and neurological functionalities. Herein, trilayered electrospun doxorubicin@bovine serum albumin/poly(ε-caprolactone)/manganese dioxide (DOX@BSA/PCL/MnO2) nanofibers with excellent antiadhesion ability, dual glutathione/hydrogen peroxide (GSH/H2O2) responsiveness, and cascade release of Mn2+/DOX was fabricated for realizing an efficient spinal tumor therapy. In detail, Fenton-like reactions between MnO2 in the fibers outermost layer and intra-/extracellular glutathione within tumors promoted the first-order release of Mn2+. Then, sustained release of DOX from the fibers’ core layer occurred along with the infiltration of degradation fluid. Such release behavior avoided toxic side effects of drugs, regulated inflammatory tumor microenvironment, amplified tumor elimination efficiency through synergistic chemo-/chemodynamic therapies, and inhibited recurrence of spinal tumors. More interestingly, magnetic resonance and photoacoustic dual-modal imaging enabled visualizations of tumor therapy and material degradation in vivo, achieving rapid pathological analysis and diagnosis. On the whole, such versatile hierarchical-structured nanofibers provided a reference for rapid and potent theranostic of spinal cancer in future clinical translations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Release Behaviors Of Electrospun Nanofibers In Vitromentioning

confidence: 89%

Section: Release Behaviors Of Electrospun Nanofibers In Vitromentioning

confidence: 99%

See 3 more Smart Citations

Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Qian

et al. 2022

ACS Nano

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Design and Properties of Antimicrobial Biomaterials Surfaces

Mehrjou

Liu

et al. 2022

Adv Healthcare Materials

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Emergence of antibiotic-resistance pathogens has caused serious health issues and if the current trend is to continue, treatment of the infection will become complicated and even unsuccessful due to new antimicrobial resistance (AMR). Therefore, there is a global drive to identify new methods to treat infection and develop better antibacterial materials and therapy. Although new and more potent antibiotics have aided the fight against microbes, they only offer a temporary solution because future bacteria strains may become resistant to these antibiotics and drugs. Recently, application of non-biological methods such as, electrical currents and photothermal/dynamic therapies to kill bacteria, reveal new approaches to design antimicrobial biomaterials, as complications stemming from drug-resistant bacteria can be obviated. Furthermore, recent research has focused on mimicking the surface patterns on plants and insects such as lotus leaves and dragonfly wings. Bio-inspired micro/nano patterns have been replicated on a variety of biomaterials to improve the bacterial resistance and other properties with good success. This is an exciting research area with immense practical and clinical potentials. In this review, recent advances in the application of chemical/biological approaches to combat bacterial infection and AMR are summarized and the related mechanisms are discussed.

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Functionalized Superhydrophobic Coatings with Electro‐Photothermal Effect for All‐Day Durable Anti‐Icing

Deng,

Du,

Chen

et al. 2024

Adv Materials Inter

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Superhydrophobic surfaces offer notable advantages, including markedly low water affinity and reduced ice adhesion strength. Nevertheless, their practical utility is impeded by their limited durability and vulnerability to failure in cold and humid environments. In this study, a novel approach for devising an electro‐photothermal superhydrophobic (EPS) nanocomposite coating is presented. The findings indicate that the EPS nanocomposite coating exhibits both physical and chemical self‐cleaning attributes, showcasing a synergistic interplay of superhydrophobicity, electrothermal, and photothermal characteristics. The superhydrophobic coating delays icing about four times longer than the original coating. At ambient temperatures of −20 °C, the coating stacked with an electro‐ and photo‐thermal performance de‐icing layer reduces the de‐icing time by about 5 times more than the purely photo‐thermal performance de‐icing time, and reduces the de‐icing time by about 4 times more than the purely electro‐thermal de‐icing time. Furthermore, the EPS surface demonstrates the capability to sustain temperatures above 0 °C through the photothermal effect on sunny days, utilizing both the electrothermal and photothermal effects on cloudy days, and relying on the electrothermal effect during cold nights. The research introduces a novel method for fabricating functional materials, pertinent to practical anti‐icing and de‐icing applications.

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Biomimetic hierarchical nanofibrous surfaces inspired by superhydrophobic lotus leaf structure for preventing tissue adhesions

Cited by 28 publications

References 38 publications

Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Design and Properties of Antimicrobial Biomaterials Surfaces

Functionalized Superhydrophobic Coatings with Electro‐Photothermal Effect for All‐Day Durable Anti‐Icing

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