Biomimetic coatings enhance tribocorrosion behavior and cell responses of commercially pure titanium surfaces

Abstract

Biofunctionalized surfaces for implants are currently receiving much attention in the health care sector. Our aims were (1) to create bioactive Ti-coatings doped with Ca, P, Si, and Ag produced by microarc oxidation (MAO) to improve the surface properties of biomedical implants, (2) to investigate the TiO2 layer stability under wear and corrosion, and (3) to evaluate human mesenchymal stem cells (hMSCs) responses cultured on the modified surfaces. Tribocorrosion and cell experiments were performed following the MAO treatment. Samples were divided as a function of different Ca/P concentrations and treatment duration. Higher Ca concentration produced larger porous and harder coatings compared to the untreated group (p < 0.001), due to the presence of rutile structure. Free potentials experiments showed lower drops (-0.6 V) and higher coating lifetime during sliding for higher Ca concentration, whereas lower concentrations presented similar drops (-0.8 V) compared to an untreated group wherein the drop occurred immediately after the sliding started. MAO-treated surfaces improved the matrix formation and osteogenic gene expression levels of hMSCs. Higher Ca/P ratios and the addition of Ag nanoparticles into the oxide layer presented better surface properties, tribocorrosive behavior, and cell responses. MAO is a promising technique to enhance the biological, chemical, and mechanical properties of dental implant surfaces.

Tribo-electrochemical behavior of bio-functionalized TiO2 nanotubes in artificial saliva: Understanding of degradation mechanisms

“…As a consequence of wear-corrosion processes taking place at implant/ bone interface, wear debris and corrosion products may be released to the implant surroundings and induce to adverse biological reactions and, ultimately, lead to implant loosening [17][18][19]. Various studies have been recently conducted to investigate the degradation of Ti-based implant materials by tribocorrosion processes [20][21][22][23][24][25][26][27][28]. In spite of the negative impact that tribocorrosion processes may have on the long term biological and mechanical stability of dental implants, the development of new implant systems addressing an integrated approach, which includes wear-corrosion resistance as a pre-requisite for implant success, is still lacking [29].…”

“…Furthermore, these nanostructures have shown the ability to display antimicrobial properties and thus inhibit microbial infections [37][38][39][40][41][42][43][44][45]. Additionally, TiO 2 nanotubes possess a lower elastic modulus (36-43 GPa) than cp-Ti (120-166 GPa), which is closer to that of natural bone (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and thus TiO 2 nanotubular structured Ti surfaces are expected to have improved biomechanical compatibility, by reducing stress shielding effect [46][47][48][49].…”

Electroless Ni–B Coating of Pure Titanium Surface for Enhanced Tribocorrosion Performance in Artificial Saliva and Antibacterial Activity

“…However, the formation of a bacterial surface biofilm, compromised immunity at the implant/tissue interface and poor tribological performance may lead to persistent infections on and around corrosion resistant Ti biomaterials used in corrosive environments [1,2]. Thus, numerous strategies focusing on the surface modification of Ti alloys have been employed to render them protection from both wear, corrosion and even tribocorrosion [3][4][5]. The strategies include physical vapour deposition [6], thermal spray [6,7], ion or laser nitriding [8][9][10], thermal oxidation [11,12], micro-arc oxidation [13][14][15], diffusion [16] and anodic oxidation treatments [17].…”

Progression of Bio-Tribocorrosion in Implant Dentistry

“…After screening full texts, a total of 44 studies were included considering the tribocorrosion analyses for dental implants and frameworks applications. The characteristics of the 44 studies (Vieira et al, 2006;Banu et al, 2008;Richard et al, 2010;Souza et al, 2010aSouza et al, , 2012Sivakumar et al, 2011;Dimah et al, 2012;Mardare et al, 2012;Mathew et al, 2012a,b;Albayrak et al, 2013;Alves et al, 2013Alves et al, , 2014Alves et al, , 2017Alves et al, , 2018Benea et al, 2013Benea et al, , 2015Benea et al, , 2017Licausi et al, 2013a,b;Fazel et al, 2015;Figueiredo-Pina et al, 2015;Golvano et al, 2015;Oliveira et al, 2015;Buciumeanu et al, 2016Buciumeanu et al, , 2017Correa et al, 2016;Guinon Pina et al, 2016;Marques et al, 2016;Mindivan et al, 2016;Pontes et al, 2016;Sampaio et al, 2016b;Silva et al, 2016;Bryant and Neville, 2017;Danaila and Benea, 2017;Mindivan and Mindivan, 2018;Sikora et al, 2018;Trino et al, 2018;Wang et al, 2018;Branco et al, 2019;Corne et al, 2019;Cui et al, 2019a,b;…”

“…Surface modifications have also been studied in the last years to improve the tribocorrosion properties and biological response of Ti and its alloys Danaila and Benea, 2017;Cui et al, 2019b). Several techniques such as plasma electrolytic oxidation, sandblasting and acid etching, magnetron sputtering, ion implantation, vapor deposition, and others have been employed to produce thick Ti coatings that can enhance the surface characteristics (Alves et al, 2014;Marques et al, 2016;Cui et al, 2019a). Coatings deposition have shown benefits from the mechanical and biological point of view with a reduction in the ions release and an increase in the corrosion and tribocorrosion resistance of Ti and its alloys Danaila and Benea, 2017).…”