Biomimetic and mesoporous nano-hydroxyapatite for bone tissue application: a short review

Molino, Giulia; Palmieri, Maria Chiara; Montalbano, Giorgia; Fiorilli, Sonia Lucia; Brovarone, Chiara Vitale

doi:10.1088/1748-605x/ab5f1a

Cited by 76 publications

(40 citation statements)

References 76 publications

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“…It is known that gold nanoparticle size and shape can influence the osteogenesis of mesenchymal stem cells [70]. In addition, porous materials, such as mesoporous bioactive glass nanoparticles [33][34][35][36]71], mesoporous hydroxyapatite [72], and mesoporous ceria (MCeO2) [37,38], have been found to directly promote osteoblast differentiation. For instance, cerium oxide nanoparticles-modified bioglass could enhance bone regeneration by activating the extracellular signal-regulated kinase (ERK) signaling pathway [38].…”

Section: Pnms For Bone Regenerationmentioning

confidence: 99%

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Zhang

Xiao

2021

Pharmaceutics

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Porous nanomaterials (PNMs) are nanosized materials with specially designed porous structures that have been widely used in the bone tissue engineering field due to the fact of their excellent physical and chemical properties such as high porosity, high specific surface area, and ideal biodegradability. Currently, PNMs are mainly used in the following four aspects: (1) as an excellent cargo to deliver bone regenerative growth factors/drugs; (2) as a fluorescent material to trace cell differentiation and bone formation; (3) as a raw material to synthesize or modify tissue engineering scaffolds; (4) as a bio-active substance to regulate cell behavior. Recent advances in the interaction between nanomaterials and cells have revealed that autophagy, a cellular survival mechanism that regulates intracellular activity by degrading/recycling intracellular metabolites, providing energy/nutrients, clearing protein aggregates, destroying organelles, and destroying intracellular pathogens, is associated with the phagocytosis and clearance of nanomaterials as well as material-induced cell differentiation and stress. Autophagy regulates bone remodeling balance via directly participating in the differentiation of osteoclasts and osteoblasts. Moreover, autophagy can regulate bone regeneration by modulating immune cell response, thereby modulating the osteogenic microenvironment. Therefore, autophagy may serve as an effective target for nanomaterials to facilitate the bone regeneration process. Increasingly, studies have shown that PNMs can modulate autophagy to regulate bone regeneration in recent years. This paper summarizes the current advances on the main application of PNMs in bone regeneration, the critical role of autophagy in bone regeneration, and the mechanism of PNMs regulating bone regeneration by targeting autophagy.

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Section: Pnms For Bone Regenerationmentioning

confidence: 99%

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Zhang

Xiao

2021

Pharmaceutics

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“…In recent years, many reviews on hydroxyapatite have been published, and most of them focus on the application and preparation of HA [12][13][14][15]. Both physicians and such as brittleness and easy aggregation still exist [11]; therefore, there is still a long way to go to prepare satisfying HA-based materials.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, many reviews on hydroxyapatite have been published, and most of them focus on the application and preparation of HA [12][13][14][15]. Both physicians and materials scientists have paid much attention to the investigation and application of HA-based materials.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

et al. 2021

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Hydroxyapatite (HA) is widely used in bone tissue engineering for its bioactivity and biocompatibility, and a growing number of researchers are exploring ways to improve the physical properties and biological functions of hydroxyapatite. Up to now, HA has been used as inorganic building blocks for tissue engineering or as nanofillers to blend with polymers, furthermore, various methods such as ion doping or surface modification have been also reported to prepare functionalized HA. In this review, we try to give a brief and comprehensive introduction about HA-based materials, including ion-doped HA, HA/polymer composites and surface modified HA and their applications in bone tissue engineering. In addition, the prospective of HA is also discussed. This review may be helpful for researchers to get a general understanding about the development of hydroxyapatite based materials.

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“…The functionality of the regenerated tissue depends on the micro- and nano-structure of the 3D scaffold. The latter should possess interconnected pores that support vascularization, transport of nutrients and metabolic waste as well as maintaining the mechanical features of strength and toughness 52 . The percolation phenomenon associated with the apatite mineral content within MCF leads to a bistable behaviour that influences bone tissue properties.…”

Section: Discussionmentioning

confidence: 99%

Percolation networks inside 3D model of the mineralized collagen fibril

Bini

Pica

Marinozzi

et al. 2021

Sci Rep

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Bone is a hierarchical biological material, characterized at the nanoscale by a recurring structure mainly composed of apatite mineral and collagen, i.e. the mineralized collagen fibril (MCF). Although the architecture of the MCF was extensively investigated by experimental and computational studies, it still represents a topic of debate. In this work, we developed a 3D continuum model of the mineral phase in the framework of percolation theory, that describes the transition from isolated to spanning cluster of connected platelets. Using Monte Carlo technique, we computed overall 120 × 106 iterations and investigated the formation of spanning networks of apatite minerals. We computed the percolation probability for different mineral volume fractions characteristic of human bone tissue. The findings highlight that the percolation threshold occurs at lower volume fractions for spanning clusters in the width direction with respect to the critical mineral volume fractions that characterize the percolation transition in the thickness and length directions. The formation of spanning clusters of minerals represents a condition of instability for the MCF, as it could be the onset of a high susceptibility to fracture. The 3D computational model developed in this study provides new, complementary insights to the experimental investigations concerning human MCF.

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Biomimetic and mesoporous nano-hydroxyapatite for bone tissue application: a short review

Cited by 76 publications

References 76 publications

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Percolation networks inside 3D model of the mineralized collagen fibril

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