Biomimetic AgNPs@antimicrobial peptide/silk fibroin coating for infection-trigger antibacterial capability and enhanced osseointegration

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

“…Among them, antimicrobial peptides (AMP) offer new possibilities for this idea because of their difficulty in causing bacterial resistance and the versatility that can be obtained through flexible amino acid sequence design. Zhou et al designed antimicrobial peptides containing osteogenic fragments attached to AgNP through hydrogen bonding [ 193 ]. Peptide rods covered with AgNPs@AMP functional coating promote osteogenic gene expression (ALP, COL 1, β-Actin, OCN and Runx-2) and osseointegration in vivo.…”

“…Zhou 2022 [193] AgNPs@AMP functionally coated peptide rods AgNPs@AMP functional coating promote osteogenic gene expression (ALP, COL 1, β-Actin, OCN and Runx-2) and osseointegration in vivo.…”

Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections

“…The drug release process of Sim-HA-Ti6Al4V was evaluated according to previous studies, with modifications [ 26 , [28] , [29] , [30] ]. Sim-Low and Sim-High plates were placed into 5 ml falcon cubes containing 2 ml PBS.…”

“…According to previous studies [ 28 , 31 ], the spread plate assay was performed to quantitatively evaluate the antibacterial effect of Sim-HA-Ti6Al4V in vitro . After culturing S. aureus on plates for 24 h, the adherent bacteria attached to the disc samples were collected ultrasonically (50HZ, 5 min) in PBS after vortexing rapidly for 1 min.…”

Antibacterial coatings on orthopedic implants

“…By attaching an AMP with an osteogenic fragment to the surface of AgNPs via the hydrogen bond and carrying AgNP@AMP with collagen-structured filament (SF), Zhou et al. [ 304 ] prepared antibacterial coatings that can be triggered by infections. The results showed that the Ag@AP/SF has significant pH-responsive release properties.…”