Biometric variations and oxidative stress responses in juvenile<i>Clarias gariepinus</i>exposed to Termex®

Nnadi, JU; Dimelu, I; Nwani, SI; Madu, J. M.; Atama, C.; Attamah, GN; Okwor, JI; Nwani, CD

doi:10.2989/16085914.2018.1445615

Cited by 9 publications

(4 citation statements)

References 40 publications

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“…85 The increase in H 2 O 2 levels is supported by Svensson et al 86 who reported that the sulfhydryl of microsomal GST's 49th cysteine could speci cally combine with H 2 O 2 , thus enhancing GST activity. Nnadi et al 21 reported signi cant SOD activity reductions and CAT activity elevations in C. gariepinus exposed to imidacloprid, similar to our ndings. However, contrary to our results, they found that imidacloprid induced a signi cant reduction in GPx activity in exposed cat sh.…”

Section: Resultssupporting

confidence: 91%

“…The value obtained in this study is considerably higher than the previously reported 96-h LC 50 (10.16 µg/L) for C. gariepinus. 21 However, similar values have been reported for imidacloprid in other sh species, including Danio rerio (143.7 mg/L) 37 and Misgurnus anguillicaudatus (145.8 mg/L) 38 . Fish behavior varied with concentration and time of exposure.…”

Section: Resultssupporting

confidence: 71%

“…80 To deal with oxidative stress and prevent excessive reactive oxygen species (ROS) formation, which can cause oxidative damage to nucleic acids, lipids, and proteins, sh produce a variety of anti-oxidative defenses including GPx, CAT, and SOD. 21,41,81,82 The role of GST is to catalyze the detoxi cation of harmful compounds via the conjugation of glutathione. 83 The current study demonstrated reduced SOD, and elevated GPx, CAT, GST, and TAC in C. gariepinus exposed to imidacloprid.…”

Section: Resultsmentioning

confidence: 99%

“…Although there is little information available about its toxicity on aquatic vertebrates including sh, several studies have assessed the toxic effects of imidacloprid on several endpoints of different species of sh in various parts of the world. 14,21,22 Imidacloprid has been reported to cause DNA damage and oxidative stress 14 decreased hatching rate of fertilized eggs 22 and histopathological alterations in tissues 23 of different sh species. Nonetheless, no study has conducted a broad range of assessments of behavioral and physiological responses and biomarkers for a sh species.…”

Section: Introductionmentioning

confidence: 99%

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Does short-term exposure to a Neonicotinoid insecticide trigger Biochemical and Physiological responses in Juvenile catfish?

Erhunmwunse

Pajiah

Victory

et al. 2022

Preprint

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Imidacloprid is among the most widely used insecticides and may contaminate surface waters, yet there is limited information available on their effects on fish. In the present study, juvenile catfish (Clarias gariepinus) were exposed to 100, 130, 160, and 190 mg/L of imidacloprid for 96 hours, and the effects on mortality, behavior, hepatic and endocrine functions, oxidative stress, and tumor and inflammatory responses were investigated. The 96 hours LC50 was 166.60 (143.38-193.59 95% confidence intervals) mg/L with mortality recorded at concentrations ≥ 130 mg/L. Exposure to imidacloprid induced behavioral alterations and clinical symptoms including gulping, hypoactivity, abnormal surface distribution, loss of buoyancy, and excessive mucus secretion. Furthermore, amylase, lipase, conjugate bilirubin, carbohydrate antigen 19 − 9 (CA 19 − 9), thyroid stimulating hormone (TSH), and glutathione peroxidase (GPx) activity were significantly increased, while significant reductions were observed in triiodothyronine (T3) and superoxide dismutase (SOD) activity. Non-significant changes were observed in aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, 17β- estradiol (E2), thyroxine (T4), C-reactive protein (CRP), glutathione S-transferases (GST), total antioxidant capacity (TAC) and catalase (CAT) activity. Our results demonstrate that imidacloprid causes behavioral, hepatic, and endocrine toxicity in catfish as well as oxidative stress and tumor marker elevation. Our findings show that short-term exposure to imidacloprid triggers biochemical and physiological responses in juvenile catfish.

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Section: Resultssupporting

confidence: 91%