Biometallorganische Chemie – Übergangsmetallkomplexe mit α-Aminosäuren und Peptiden

Abstract

Ein neues interdisziplinäres Forschungsgebiet ist die Biometallorganische Chemie; sie befaßt sich mit der Einführung von metallorganischen Fragmenten in Biomoleküle (siehe z. B. Struktur rechts). Die „klassischen”︁ α‐Aminosäure‐ und Peptidliganden haben sich dabei als besonders vielseitig erwiesen und eröffnen unter anderem einen Zugang zu stereochemisch interessanten Verbindungen. α‐Aminosäuren und Peptide können durch metallorganische Verbindungen synthetisiert, markiert, stabilisiert oder aktiviert werden.

Ferrocenoyl peptides with sulfur-containing side chains: synthesis, solid state and solution structures

“…Conjugates of ferrocene and amino acids or peptides have been intensively studied in recent years [1]. The resulting conjugates were investigated as electrochemical sensors for organic substrates [2][3][4][5] or anions [6,7].…”

Synthesis and thermal studies of mixed ligand complexes of Cu(II), Co(II), Ni(II) and Cd(II) with mercaptotriazoles and dehydroacetic acid

“…The importance of similar pyrones as potential fungicides is reinforced by the existence of several natural fungicides possessing structures analogous to 5, 6-dihydro dehydroacetic acid, like alternaric acid, the podoblastins and lachnelluloic acid [3][4][5], studies have shown that such compounds and their complexes have very interesting biological properties [6][7][8][9][10][11][12][13]. Like dehydroacetic acid, mercaptotriazoles and their complexes have been shown to posses enhanced biological activities [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The work of the present paper is devoted to the synthesis and characterization of some new mixed ligand complexes containing mercaptotriazoles and dehydroacetic acid.…”

The use of 3,3-bis(2-imidazolyl) propionic acid (bip-OH) as a new chelating ligand for Re(CO)3 and Ru complexes: Formation of organometallic PNA oligomers with (bip)Re(CO)3 and their interaction with complementary DNA

“…Bioorganometallic chemistry is a nascent field of research combining organometallic compounds and reactivity with aspects from biological, pharmaceutical and medicinal chemistry [1][2][3][4]. One prominent use has been the development of new immunoassays which do not rely on radioactive or fluorescent detection.…”

“…They were also amendable for solid phase peptide synthesis protocols as shown recently for a Mo(allyl)(histidinate)(CO) 3 bioconjugate with the neuropeptide enkephalin [27]. We now report the synthesis and characterization of Re(CO) 3 and Ru(bpy) 2 complexes with 1. In addition, the Re(bip)(CO) 3 fragment is also coupled to PNA decamers by solid phase synthesis.…”