BioMEMS for drug delivery

Shawgo, Rebecca S.; Grayson, Amy C. Richards; Li, Yawen; Cima, Michael J.

doi:10.1016/s1359-0286(02)00032-3

Cited by 161 publications

(76 citation statements)

References 21 publications

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“…oral tablets, injections, pulmonary, transdermal (Shawgo et al, 2002;Tao & Desai, 2003;Hilt & Peppas, 2005;Chien & Lin 2006), aerosols and ointments (Langer, 1990) could provide one or more of the following benefits compared to conventional dosage forms including (Langer, 1990;Putney & Burke, 1998;Medlicott & Tucker, 1999;Hilt & Peppas, 2005;Chien & Lin 2006;Jain et al, 2011;Lee et al, 2012;Siegel & Rathbone, 2012) the following factors.…”

Section: Controlled Release and Pulsatile Release Of Drugmentioning

confidence: 99%

“…The biocompatibility of a fabricate drug delivery microreservoir device depends only on those materials in contact with tissue (Grayson et al, 2004a-c;Graham-Rowe, 2012) such as, silicon (used as a substrate and structural material), gold (used for electrodes) and silicon dioxide, silicon nitride etc. (used as dielectrics) (Shawgo et al, 2002;Chung et al, 2008). The implantable microchip devices directly interact with the body so the biocompatibility of silicon and other materials of fabrication have become much more important (Grayson et al, 2004a-c).…”

Section: Biocompatibility Of Implantable Microchipmentioning

confidence: 99%

“…Silicon is exposed to body fluids inside the wells which causes bio-incompatibility, but can be silanated by a number of simple surface passivation processes. Therefore, the surface modifications can be applied to increase biocompatibility and decrease biofouling (Erickson et al, 2008;Shawgo et al, 2002).…”

Section: Biocompatibility Of Implantable Microchipmentioning

confidence: 99%

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Implantable microchip: the futuristic controlled drug delivery system

2014

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There is no doubt that controlled and pulsatile drug delivery system is an important challenge in medicine over the conventional drug delivery system in case of therapeutic efficacy. However, the conventional drug delivery systems often offer a limited by their inability to drug delivery which consists of systemic toxicity, narrow therapeutic window, complex dosing schedule for long term treatment etc. Therefore, there has been a search for the drug delivery system that exhibit broad enhancing activity for more drugs with less complication. More recently, some elegant study has noted that, a new type of micro-electrochemical system or MEMS-based drug delivery systems called microchip has been improved to overcome the problems related to conventional drug delivery. Moreover, micro-fabrication technology has enabled to develop the implantable controlled released microchip devices with improved drug administration and patient compliance. In this article, we have presented an overview of the investigations on the feasibility and application of microchip as an advanced drug delivery system. Commercial manufacturing materials and methods, related other research works and current advancement of the microchips for controlled drug delivery have also been summarized.

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Section: Controlled Release and Pulsatile Release Of Drugmentioning

confidence: 99%

Section: Biocompatibility Of Implantable Microchipmentioning

confidence: 99%

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Implantable microchip: the futuristic controlled drug delivery system

2014

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“…[22] A drop in electrical resistance of the skin was used to identify needle penetration since visual observation of needle insertion was extremely difficult. The electrical resistance of skin's outermost layer, the stratum corneum, is much greater than deeper tissues, therefore the resistance of the skin drops dramatically as soon as a needle penetrates.…”

Section: Measurement Of Insertion Force Into Human Skinmentioning

confidence: 99%

Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2011

Journal of Pharmacy and Pharmacology

342

207

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Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum. Microneedles deliver the drug into the epidermis without disruption of nerve endings. Recent advances in the development of microneedles are discussed in this review for the benefit of young scientists and to promote research in the area. Key findings Microneedles are fabricated using a microelectromechanical system employing silicon, metals, polymers or polysaccharides. Solid coated microneedles can be used to pierce the superficial skin layer followed by delivery of the drug. Advances in microneedle research led to development of dissolvable/degradable and hollow microneedles to deliver drugs at a higher dose and to engineer drug release. Iontophoresis, sonophoresis and electrophoresis can be used to modify drug delivery when used in concern with hollow microneedles. Microneedles can be used to deliver macromolecules such as insulin, growth hormones, immunobiologicals, proteins and peptides. Microneedles containing 'cosmeceuticals' are currently available to treat acne, pigmentation, scars and wrinkles, as well as for skin tone improvement. Summary Literature survey and patents filled revealed that microneedle-based drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional transdermal techniques.

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“…Equally as important as the loading volume, implantable BioMEMS drug delivery systems must also be power efficient for their intended long term operation and drug dosing [38]. One of the greatest advantages of BioMEMS in the treatment of chronic diseases is that, in addition to localized/targeted delivery, they are able to provide personalized drug delivery in the form of a continuous pulsatile drug release profile [2,39,40].…”

Section: Long Operation Timementioning

confidence: 99%

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

Tng

Song

et al. 2012

Micromachines

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Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS) technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

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BioMEMS for drug delivery

Cited by 161 publications

References 21 publications

Implantable microchip: the futuristic controlled drug delivery system

Implantable microchip: the futuristic controlled drug delivery system

Microneedles: an emerging transdermal drug delivery system

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

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