Biomedical studies on lipid peroxidation and erythrocyte fragility during the process of aging

Kumar, Arun

doi:10.1016/s2221-1691(11)60058-0

Cited by 11 publications

(4 citation statements)

References 10 publications

(7 reference statements)

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“…The OH is known to cause DNA damage by degradation of deoxyribose moiety (Kumar 2011); however, the scavenging or chelation of radicals by any substance attributes the antioxidant capacity of that particular substances (Ganie et al 2012a, Parray et al 2010Parray et al 2011), and in our study, both the alcoholic plant extracts showed a good scavenging activity of OH radicals. Similarly, Saenjum et al (2010) reported the protective effect of Caesalpinia sappan extracts on DNA damage induced by hydroxyl radical at the same concentration tested.…”

Section: Antioxidant Activitysupporting

confidence: 43%

Antimicrobial and antioxidant activity of methanol extracts of Arnebia benthamii (Wall ex. G. Don) Johnston—a critically endangered medicinal plant of North western Himalaya

et al. 2015

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Background: Arnebia benthamii is one of the promising folklore medicinal plants which is being traditionally used over the years for the treatment of various prevailing diseases in the area. The aim of this research work was to evaluate the antimicrobial activity and antioxidant activity of methanolic plant extract. Methods: Antimicrobial activity of the plant extract (250-500 μg/ml concentration) was analyzed against Escherichia coli CD0006, Pseudomonas aeruginosa CD0023, Shigella flexneri CD0033, Klebsiella pneumonia CD0049, Salmonella typhimurium CD0003, Staphylococcus aureus CD0001, Aspergillus versicolor CDF0011, Candida albicans CDF0032, Candida kruesie CDF0016, Candida parapsilosis CDF0013, Aspergillus flavus CDF0024, and Acremonium spp. CDF0027. The free radical scavenging assay of the plant extracts was evaluated by various antioxidant methods.

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Section: Antioxidant Activitysupporting

confidence: 43%

Antimicrobial and antioxidant activity of methanol extracts of Arnebia benthamii (Wall ex. G. Don) Johnston—a critically endangered medicinal plant of North western Himalaya

et al. 2015

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“…This radical has the ability to bond with nucleotides in DNA and can cause strand breakage, which leads to carcinogenesis, mutagenesis and cytotoxicity (Kumarappan et al, 2012). The OH radical is identified as major cause of DNA damage by degradation of deoxyribose moiety (Kumar, 2011;Parray et al, 2015). However, the scavenging or chelation of radicals by any substance attributes the antioxidant capacity of that particular substance (Orhan et al, 2008).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Biological efficacy and radical scavenging potential of shikonin in Arnebia benthamii (Wall ex. G Don) Johnston

Parray

Hamid

Kamili

et al. 2015

Industrial Crops and Products

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“…Since the primary function of Hp in plasma is to strongly bind Hb to prevent highly toxic free Hb from reaching the kidneys, our results indicate that the release of Hb from aging red blood cells [ 37 , 38 ] is a likely explanation for the increased Hp-Hb concentration with age. Although we did not quantify free Hp in plasma, it has been previously shown by Zhang et al that the plasma Hp concentration, but not the Hp isoform, was linked to the outcome after AIS [ 39 ].…”

Section: Discussionmentioning

confidence: 93%

Quantification of human plasma metalloproteins in multiple sclerosis, ischemic stroke and healthy controls reveals an association of haptoglobin-hemoglobin complexes with age

et al. 2022

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Advanced analytical methods play an important role in quantifying serum disease biomarkers. The problem of separating thousands of proteins can be reduced by analyzing for a ‘sub-proteome’, such as the ‘metalloproteome’, defined as all proteins that contain bound metals. We employed size exclusion chromatography (SEC) coupled to an inductively coupled plasma atomic emission spectrometer (ICP-AES) to analyze plasma from multiple sclerosis (MS) participants (n = 21), acute ischemic stroke (AIS) participants (n = 17) and healthy controls (n = 21) for Fe, Cu and Zn-metalloproteins. Using ANOVA analysis to compare the mean peak areas among the groups revealed no statistically significant differences for ceruloplasmin (p = 0.31), α2macroglobulin (p = 0.51) and transferrin (p = 0.31). However, a statistically significant difference was observed for the haptoglobin-hemoglobin (Hp-Hb) complex (p = 0.04), being driven by the difference between the control group and AIS (p = 0.012), but not with the MS group (p = 0.13), based on Dunnes test. A linear regression model for Hp-Hb complex with the groups now adjusted for age found no statistically significant differences between the groups (p = 0.95), but was suggestive for age (p = 0.057). To measure the strength of association between the Hp-Hb complex and age without possible modifications due to disease, we calculated the Spearman rank correlation in the healthy controls. The latter revealed a positive association (r = 0.39, 95% Confidence Interval = (-0.05, 0.83), which suggests that either the removal of Hp-Hb complexes from the blood circulation slows with age or that the release of Hb from red blood cells increases with age. We also observed that the Fe-peak corresponding to the Hp-Hb complex eluted ~100 s later in ~14% of all study samples, which was not correlated with age or disease diagnosis, but is consistent with the presence of the smaller Hp (1–1) isoform in 15% of the population.

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Biomedical studies on lipid peroxidation and erythrocyte fragility during the process of aging

Cited by 11 publications

References 10 publications

Antimicrobial and antioxidant activity of methanol extracts of Arnebia benthamii (Wall ex. G. Don) Johnston—a critically endangered medicinal plant of North western Himalaya

Antimicrobial and antioxidant activity of methanol extracts of Arnebia benthamii (Wall ex. G. Don) Johnston—a critically endangered medicinal plant of North western Himalaya

Biological efficacy and radical scavenging potential of shikonin in Arnebia benthamii (Wall ex. G Don) Johnston

Quantification of human plasma metalloproteins in multiple sclerosis, ischemic stroke and healthy controls reveals an association of haptoglobin-hemoglobin complexes with age

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