Antimicrobial and antioxidant activity of methanol extracts of Arnebia benthamii (Wall ex. G. Don) Johnston—a critically endangered medicinal plant of North western Himalaya

Abstract

Background: Arnebia benthamii is one of the promising folklore medicinal plants which is being traditionally used over the years for the treatment of various prevailing diseases in the area. The aim of this research work was to evaluate the antimicrobial activity and antioxidant activity of methanolic plant extract. Methods: Antimicrobial activity of the plant extract (250-500 μg/ml concentration) was analyzed against Escherichia coli CD0006, Pseudomonas aeruginosa CD0023, Shigella flexneri CD0033, Klebsiella pneumonia CD0049, Salmonella typhimurium CD0003, Staphylococcus aureus CD0001, Aspergillus versicolor CDF0011, Candida albicans CDF0032, Candida kruesie CDF0016, Candida parapsilosis CDF0013, Aspergillus flavus CDF0024, and Acremonium spp. CDF0027. The free radical scavenging assay of the plant extracts was evaluated by various antioxidant methods.

Phytochemical Screening, Antimicrobial, Antipellicle and Antibiofilm Activities of the Root of Alpine Medicinal Plant (<i>Arnebia euchroma</i> (Royle) I.M.Johnst.)

“…As known, in addition to the shikalkin derivatives, the A. euchroma root contains some new compounds [55]. The antimicrobial effect of A. euchroma has been reported in many previous studies [56,57]. Haghbeen et al [20] reported that A. euchroma root THF-extract grown in Iran showed antimicrobial activity (shikalkin pigment) and demonstrated that the highest control yield of the extract was obtained on M. luteus.…”

A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers

“…Researchers also investigated some derivatives of the Sh+ikonin component and their cytotoxic effect and antioxidant activity [ 290 , 291 ]. From the plant species the methanol extracted has antioxidant and antimicrobial effects, and hydroxyl radicals for DNA damage protection [ 292 ]. The phytochemicals existing in the Arnebiaeu chroma plant are utilized for treating carcinogenic diseases.…”

Manipulation of Plant Growth Regulators on Phytochemical Constituents and DNA Protection Potential of the Medicinal Plant Arnebia benthamii

“…It is an alpine herb occurring at an altitude of 3500–4000 m, from Kashmir to Western Nepal, normally on open slopes with stony or rocky substrates. In Kashmir Valley, it is confined to certain areas such as Sinthon Top, Duksum, Karnah, Gurez, Lolab, Sonamarg, and Kargil and is rarely found [ 8 , 9 ]. It is classified as a critically endangered nonendemic plant of Kashmir [ 10 , 11 ].…”

“…are reported to be traditional ayurvedic medicines for the treatment of diseases of the throat and tongue, fevers, and cardiac symptoms. The flowers are known to have a comforting effect on heart patients [ 11 ], while its roots have antiseptic and antibiotic properties [ 9 ]. Conservation of the existing germplasm of such a useful and threatened species is, therefore, a strategic need.…”