2021
DOI: 10.1016/j.jconrel.2020.09.045
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Biomedical nanoparticle design: What we can learn from viruses

Abstract: Viruses are nanomaterials with a number of properties that surpass those of many synthetic nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered structure, come in a variety of shapes, and present unique surface elements, such as spikes. These attributes facilitate propitious biodistribution, the crossing of complex biological barriers and a minutely coordinated interaction with cells. Due to the orchestrated sequence of interactions of their stringently arranged particle corona wi… Show more

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Cited by 48 publications
(32 citation statements)
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References 231 publications
(300 reference statements)
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“…Vaccination can be the best way to produce ‘herd immunity’ and stop the spread of this pandemic. The vaccines can be of the following types based on their active components [ 8 ]. Inactivated vaccine Attenuated vaccine Peptide and protein vaccine Outer membrane based vaccine Nucleic acid based vaccine Non-replicating viral vaccine Replicating viral vaccine Virus like particle vaccine …”
Section: Nanoparticles In Vaccine Developmentmentioning
confidence: 99%
See 1 more Smart Citation
“…Vaccination can be the best way to produce ‘herd immunity’ and stop the spread of this pandemic. The vaccines can be of the following types based on their active components [ 8 ]. Inactivated vaccine Attenuated vaccine Peptide and protein vaccine Outer membrane based vaccine Nucleic acid based vaccine Non-replicating viral vaccine Replicating viral vaccine Virus like particle vaccine …”
Section: Nanoparticles In Vaccine Developmentmentioning
confidence: 99%
“…Coronaviruses are characterized by three glycoproteins (1) Spike protein (2) Membrane (3) envelope protein [ 7 ]. Nanotechnology has continuously been used to detect viral genome of corona, influenza, HIV, hepatitis, dengue and Nipah viruses [ 8 ]. Multiple nano-technological carriers have been used to develop novel vaccines against earlier outbreaks of coronaviruses.…”
Section: Introductionmentioning
confidence: 99%
“…The NP system is based on a virus-mimetic presentation of two ligands that selectively recognize mesangial surface components and enable a reliable discrimination of mesangial sites and possible off-targets. Inspired by its biological model, human adenovirus type 2 [ 40 ], the NP thereby interacts with the cell surface in a sequential manner of initial binding to the angiotensin II receptor type 1 (AT1r) via an AT1r blocker (EXP3174), followed by a presentation of previously shielded cyclic amino acid sequence (cRGD) that activates mesangial surface integrin α v β 3 and eventually triggers cell endocytosis ( Figure 1 a) [ 41 ].…”
Section: Introductionmentioning
confidence: 99%
“…Designed bio-nanomaterials are often inspired by basic processes found in nature such as molecular recognition and self-assembly ( Lehn, 2002 ; Whitesides and Grzybowski, 2002 ; Yang et al, 2020a ). Viruses present a great source of inspiration for the design of life-like materials ( Whitesides, 2015 ; Maslanka Figueroa et al, 2021 ) as they constitute simple, yet sophisticated supramolecular assemblies that contain genetic code and present well-defined rod-like or spherical morphologies. In addition, they show the ability to self-replicate, respond to physical and chemical stimuli, adapt to the environment, and evade the immune system which makes them ideal candidates to be manipulated and repurposed.…”
Section: Introductionmentioning
confidence: 99%