Biomedical engineering of polysaccharide-based tissue adhesives: Recent advances and future direction

Shokrani, Hanieh; Shokrani, Amirhossein; Seidi, Farzad; Munir, Muhammad Tajammal; Rabiee, Navid; Fatahi, Yousef; Kucinska-Lipka, Justyna; Saeb, Mohammad Reza

doi:10.1016/j.carbpol.2022.119787

Cited by 23 publications

(8 citation statements)

References 143 publications

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“…This is swiftly emerging as a new topic of research. Biocompatible polymers have been a popular focus of research for regulated medication delivery [6,60,61]. It developed out of a need for more precise and extended pharmaceutical delivery.…”

Section: Polymers In Biomedical Applicationsmentioning

confidence: 99%

Emerging Bio-Based Polymers from Lab to Market: Current Strategies, Market Dynamics and Research Trends

Joseph

Unni

Joshy

et al. 2023

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Due to the rising worldwide demand for green chemicals, the bio-based polymer market is anticipated to expand substantially in the future. The synthesis of functional polymers has been a burgeoning area of research for decades. The primary driving force behind the development of bio-based polymers has been their compostability and biodegradability, which are critical given the public concern about waste. Significant advancements in the method for refining biomass raw materials towards the creation of bio-based construction materials and products are driving this rise. Bio-based polymers with this chemical structure are more flexible and adaptive, which allows them to attain their intended characteristics and functionalities. In commercial applications and healthcare and biotechnology, where completely manufactured, naturally occurring biomolecules are utilized and such polymers have the greatest impact. At the same time, limitations in polymer architectural control, biostability, and structural dynamics hinder the creation of biocompatible and functionally varied polymers. From this standpoint, the importance of functional biosynthetic polymers in the future years is highlighted, as well as new methods for addressing the aforementioned challenges. The article comprehensively highlighted the current strategies, market dynamics, and research trends of emerging Bio-Based Polymers. In addition, the most recent scientific breakthroughs in bio-based polymers are discussed.

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Section: Polymers In Biomedical Applicationsmentioning

confidence: 99%

Emerging Bio-Based Polymers from Lab to Market: Current Strategies, Market Dynamics and Research Trends

Joseph

Unni

Joshy

et al. 2023

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“…Compared to conventional suture or stapling applications, TAs are relatively easy to implement, have minimally invasive procedures, and enable rapid application as well as minimizing the post-operative complications [ 124 , 125 ]. Utilization of TAs is categorized into 3 groups: (i) hemostasis, (ii) tissue sealing by preventing leaks of different items, such as lymphatic fluids and air and (iii) local delivery of exogenous elements [ 126 , 127 , 128 ].…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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“…From the prospect of biological materials, various types of hydrogels, such as film, foam, sponge, hydrocolloid, hydrogel, − and nanofiber film, , have been developed and applied to tissue regeneration and wound repair. Among these, hydrogel polymers have attracted much attention due to their exceptional advantages, such as excellent flexibility, , deformability, , and biocompatibility . Especially, hydrogels promote cell adhesion and growth due to their highly hydrophilic three-dimensional (3D) cross-linked network structure, similar to the natural extracellular matrix …”

Section: Introductionmentioning

confidence: 99%

HE@PCL/PCE Gel-Nanofiber Dressing with Robust Self-Adhesion toward High Wound-Healing Rate via Microfluidic Electrospinning Technology

Chen,

Liu,

Cui

et al. 2023

ACS Appl. Mater. Interfaces

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Hydrogels have attracted increasing attention in the biomedical field due to their similarity in structure and composition to natural extracellular matrices. However, they have been greatly limited by their low mechanical strength and self-adhesion for further application. Here, a gel-nanofiber material is designed for wound healing, which synergistically combines the benefits of hydrogels and nanofibers and can overcome the bottleneck of poor mechanical strength and self-adhesion in hydrogels and inadequate healing environment created by nanofibers. First, a nanofiber scaffold composed of polycaprolactone/poly(citric acid)-ε-lysine (PCL/PCE) nanofibers is fabricated via a new strategy of microfluidic electrospinning, which could provide a base for hyaluronic acid-polylysine (HE) gel growth on nanofibers. The prepared HE@PCL/ PCE gel-nanofiber possesses high tensile strength (24.15 ± 1.67 MPa), excellent air permeability (656 m 3 /m 2 h kPa), outstanding self-adhesion property, and positive hydrophilicity. More importantly, the prepared gel-nanofiber dressing shows good cytocompatibility and antibacterial properties, achieving a high wound-healing rate (92.48%) and 4.685 mm granulation growth thickness within 12 days. This material may open a promising avenue for accelerating wound healing and tissue regeneration, providing potential applications in clinical medicine.

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Biomedical engineering of polysaccharide-based tissue adhesives: Recent advances and future direction

Cited by 23 publications

References 143 publications

Emerging Bio-Based Polymers from Lab to Market: Current Strategies, Market Dynamics and Research Trends

Emerging Bio-Based Polymers from Lab to Market: Current Strategies, Market Dynamics and Research Trends

Application of Convergent Science and Technology toward Ocular Disease Treatment

HE@PCL/PCE Gel-Nanofiber Dressing with Robust Self-Adhesion toward High Wound-Healing Rate via Microfluidic Electrospinning Technology

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