Biomedical coatings on magnesium alloys – A review

Hornberger, H.; Virtanen, Sannakaisa; Boccaccını, Aldo R.

doi:10.1016/j.actbio.2012.04.012

Cited by 1,118 publications

(602 citation statements)

References 101 publications

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“…Surface modifying the scaffolds increases the corrosion resistance. The surface modification can be applied by two different processing techniques of conversion coatings or deposited coatings [27]. Calcium phosphates (CaPs) with similar composition of the bone mineral component possess several beneficial properties such as excellent bioactivity and osteoconductivity for bone-graft applications [54].…”

Section: Biomedical Coatings On Magnesium Scaffoldsmentioning

confidence: 99%

“…Some physical properties of the Mg alloys, such as high specific strength and elastic modulus, are closer to those of the natural human bone compared to other traditional metal implants [27,28]. For example, compared to titanium alloys with the elastic modulus of 110-117 GPa, Mg alloys have lower modulus (41-45 GPa) leading to a decreased stress-shielding effect [29,30].…”

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confidence: 99%

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Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

234

115

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Section: Biomedical Coatings On Magnesium Scaffoldsmentioning

confidence: 99%

mentioning

confidence: 99%

Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

234

115

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“…The bulk (Mg-4Y-5.5Dy-0.5Zr)-HA composites with 10 wt.% of HA have a better corrosion resistance (I c = 5.849 9 10 5 A cm À2 , E c = À1.565 V versus SCE). It has been suggested that rare earth elements accelerate the kinetics of the formation of MgH 2 during the corrosion process, which gradually decomposes to form Mg(OH) 2 in aqueous solutions, and this could act as a barrier against further corrosion of magnesium (Ref 24,25).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Hydroxyapatite Addition on the Properties of the Mechanically Alloyed and Sintered Mg-RE-Zr Alloy

Kowalski

Nowak

Jakubowicz

et al. 2016

J. of Materi Eng and Perform

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This paper discusses the influence of the chemical composition on the microstructure, mechanical and corrosion properties of mechanically alloyed and sintered (Mg-4Y-5.5Dy-0.5Zr)-x wt.% HA composites. Mechanical alloying for 25 h of the Mg-4Y-5.5Dy-0.5Zr composition, followed by sintering under argon at 550°C for 2 h, led to the formation of a bulk alloy with an ultrafine grained microstructure. With the increase of the hydroxyapatite content in the (Mg-4Y-5.5Dy-0.5Zr)-x wt.% HA composite, a reduction of the grain sizes of the bulk material was noticeable. In the case of the bulk (Mg-4Y-5.5Dy-0.5Zr)-10 wt.% HA composite, the grain sizes of approx. 60 nm have been recorded by atomic force microscopy. The final microstructure of the synthesized composites strongly influenced the mechanical and corrosion properties. The Mg-4Y-5.5Dy-0.5Zr alloy was characterized by higher average values of YoungÕs modulus (36.6 GPa). In the case of the (Mg-4Y-5.5Dy-0.5Zr)-5 wt.% HA scaffolds with the porosity of 48%, the YoungÕs modulus was equal to 7.1 GPa. The (Mg-4Y-5.5Dy-0.5Zr)-10 wt.% HA composite was more corrosion resistant (I c = 5.849 3 10 25 A cm 22 , E c = 21.565 V versus SCE) than Mg-4Y-5.5Dy-0.5Zr alloy (I c = 4.838 3 10 24 A cm 22 , E c = 21.555 V versus SCE). The influence of hydrofluoric acid treatment on the corrosion behavior of the (Mg-4Y-5.5Dy-0.5Zr)-5 wt.% HA composite was also investigated. The electrochemical test showed that the corrosion resistance of fluoride-treated specimens was higher, compared with the untreated samples in the RingerÕs solution. In conclusion, fluoride-treated (Mg-4Y-5.5Dy-0.5Zr)-HA composites are biodegradable materials with adjustable mechanical and corrosive properties.

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“…5 Recently, magnesium (Mg) and its alloys have been presented as a new class of biodegradable metallic materials for orthopedic applications. 1,6,7 By suitable surface modification, this metal can have the mechanical properties required to meet load-bearing necessities during the bone healing process 8,9 and be capable of degrading at a controlled rate, thus allowing for surrounding tissue regeneration 10,11 Compared to permanent metallic implants such as titanium-based materials with the Young's moduli of 110-117 GPa, the Mg-based materials have significantly lower moduli (41-45 GPa). 12 As a result, the stress shielding level reduces due to their mechanical properties that are close to natural bone.…”

Section: Introductionmentioning

confidence: 99%

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

Yazdimamaghani

Razavi

Vashaee

et al. 2015

Materials Science and Engineering: C

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A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dipcoating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable barrier property of the coatings effectively delayed the degradation activity of Mg scaffold substrates. Moreover, the coatings induced the formation of apatite layer on their surface after immersion in the SBF, which can enhance the biological bone in-growth and block the microcracks and pore channels in the coatings, thus prolonging their protective effect. Furthermore, it was shown that a three times increase in the concentration of PCL-BG noticeably improved the characteristics of scaffolds including their degradation resistance and mechanical stability. Since bioactivity, degradation resistance and mechanical integrity of a bone substitute are the key factors for repairing and healing fractured bones, we suggest that PCL-BG is a suitable coating material for surface modification of Mg scaffolds.

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Biomedical coatings on magnesium alloys – A review

Cited by 1,118 publications

References 101 publications

Porous magnesium-based scaffolds for tissue engineering

Porous magnesium-based scaffolds for tissue engineering

The Effects of Hydroxyapatite Addition on the Properties of the Mechanically Alloyed and Sintered Mg-RE-Zr Alloy

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

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