Biomedical Applications of Nanoparticles

Bharathala, Subhashini; Sharma, Pratima

doi:10.1016/b978-0-12-818823-1.00008-9

Cited by 31 publications

(15 citation statements)

References 194 publications

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“…Nanoparticles are a material with a particle size from 10 to 1000 nm [ 70 ]. Compared with other delivery systems, nanoparticles have many advantages [ 71 , 72 ], which are widely used in food, medicine, and other fields [ 73 , 74 , 75 ]. The nanoparticle technology in the functional food field mainly focuses on the delivery of active substances such as lutein, astaxanthin ester, and curcumin [ 76 ].…”

Section: Delivery Systems Of Dhamentioning

confidence: 99%

Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review

2022

Foods

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Docosahexaenoic acid (DHA), mainly found in microalgae and fish oil, is crucial for the growth and development of visual, neurological, and brain. In addition, DHA has been found to improve metabolic disorders associated with obesity and has anti-inflammatory, anti-obesity, and anti-adipogenesis effects. However, DHA applications in food are often limited due to its low water solubility, instability, and poor bioavailability. Therefore, delivery systems have been developed to enhance the remainder of DHA activity and increase DHA homeostasis and bioavailability. This review focused on the different DHA delivery systems and the in vitro and in vivo digestive characteristics. The research progress on cardiovascular diseases, diabetes, visual, neurological/brain, anti-obesity, anti-inflammatory, food applications, future trends, and the development potential of DHA delivery systems were also reviewed. DHA delivery systems could overcome the instability of DHA in gastrointestinal digestion, improve the bioavailability of DHA, and better play the role of its functionality.

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Section: Delivery Systems Of Dhamentioning

confidence: 99%

Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review

2022

Foods

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“…These shortcomings have been addressed by a number of strategies including functionalization with polyethylene glycol (PEG) ( Perez et al, 2019 ), entrapment in mesoporous materials ( Nordstro¨m et al, 2019 ), encapsulation within polymeric capsules ( Uhrich et al, 1999 ), liposomes ( Ghosh Dastidar and Chakrabarti, 2019 ), and immobilization on nanomaterials ( Bharathala and Sharma, 2019 ). In this regard, a number of studies have demonstrated that by interfacing AMPs with nanomaterials, such as silica, gold, silver and carbon nanoparticles, their stability and lifespan is considerably increased ( Du and Stenzel, 2014 ; Elahi et al, 2018 ; Sharma, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Formulation of a novel antibacterial topical treatment based on Magnetite-Buforin-II-silver nanobioconjugates

Muñoz

Jaramillo

Gantiva-Diaz

et al. 2022

Front. Bioeng. Biotechnol.

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Community acquired infections caused by Meticillin-resistant Staphylococcus aureus (MRSA) have become a growing concern due to its impact on the world public health. This microorganism is a commonly spreading pathogen associated predominantly with skin infections and connected to other more severe conditions (septic shock, and generalized infection). The lack of highly effective antibiotics and treatments to control skin infections with S. aureus has led to the search of novel therapies using alternative agents such as antimicrobial peptides (AMPs). In order to obtain a viable administration route to counteract superficial skin infections (impetigo, abscesses, furuncles, and cellulitis), a topical formulation based on Magnetite-Buforin-II-silver nanobioconjugates as active antibacterial agents was designed by their dispersion in O/W concentrated emulsions. The prepared topical characterization indicated that O/W emulsions were stable in time, the droplets size remained within the appropriate values (∼1 µm) and their rheological properties, such as pseudoplastic and shear-thinning behavior, remained unchanged for up to 3 months. Additionally, hemolysis and platelet aggregation tests were acceptable (i.e., 14.72 ± 2.62% and 8.06 ± 2.90%, respectively) in compliance with the ISO-10993 standard. Furthermore, the treatment reduced significantly (p < 0.0001) the growth of both clinical isolated MRSA and wild Type S. aureus strains as evidenced by the contact diffusion method. These results are important in the context of proposing new alternatives that allow manage effectively the threat posed by the antibiotic resistant bacterial strains, which jeopardize the lives of thousands of people every year.

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“…However, microparticles have relatively low cell uptake and poor tissue penetration. Particles in the nanometer size range (nanoparticles) are more advantageous because of their ability to passively accumulate in tumors via the “enhanced permeability and retention effect” ( Bharathala and Sharma, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Andrographolide in poly(lactide-co-glycolide) Nanoparticles: Formulation Optimization and in vitro Efficacy Studies

Oseni

Azubuike

Okubanjo

et al. 2021

Front. Bioeng. Biotechnol.

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Andrographolide is a potential chemopreventive and chemotherapeutic agent that suffers from poor aqueous solubility. Encapsulation in poly(lactide-co-glycolide) (PLGA) nanoparticles can overcome solubility issues and enable sustained release of the drug, resulting in improved therapeutic efficacy. In this study, andrographolide was encapsulated in PLGA nanoparticles via emulsion solvent evaporation technique. Effect of various formulation parameters including polymer composition, polymer molecular weight, polymer to drug ratio, surfactant concentration and the organic solvent used on nanoparticle properties were investigated. A selected formulation was used to determine the effect of encapsulation in nanoparticles on andrographolide’s in vitro anticancer efficacy. Nanoparticles formulated using a polymer with 85:15 lactide to glycolide ratio and ethyl acetate as the organic solvent were found to be optimal based on average hydrodynamic particle size (135 ± 4 nm) and drug loading (2.6 ± 0.6%w/w). This formulation demonstrated sustained release of andrographolide over 48 h and demonstrated significantly greater in vitro anticancer efficacy compared to free drug in a metastatic breast cancer cell line. These results suggest that additional, more in-depth efficacy studies are warranted for the nanoparticle formulation of andrographolide.

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Biomedical Applications of Nanoparticles

Cited by 31 publications

References 194 publications

Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review

Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review

Formulation of a novel antibacterial topical treatment based on Magnetite-Buforin-II-silver nanobioconjugates

Encapsulation of Andrographolide in poly(lactide-co-glycolide) Nanoparticles: Formulation Optimization and in vitro Efficacy Studies

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