Biomedical applications of collagen

Lee, Chi H.; Singla, Anuj; Lee, Yugyung

doi:10.1016/s0378-5173(01)00691-3

Cited by 1,653 publications

(1,076 citation statements)

References 161 publications

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“…Among the natural biopolymers, collagen type I and fibrin are the most widely used [121,122], although the use of hyaluronic acid (HA) has also been advocated as it allows tissue integration and prevents adhesions to surrounding tissues [123]. The attractiveness of collagen type I is based on the fact that constitutes the major component of tendon and is removed from the body through physiological enzymatic processes, as a function of the extent of cross-linking and functionalisation [105,[124][125][126][127]. Clinically, injectable collagen hydrogels have been utilised as carriers for biological and pharmaceutical agents [128].…”

Section: Minimally Invasive Strategies For Small Tendon Injuriesmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

177

188

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Section: Minimally Invasive Strategies For Small Tendon Injuriesmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

177

188

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“…By appropriate choice of bioassay, the material presenting the optimised performance can be readily selected. The absence of adequate polymeric materials for biomedical application and, thus, the motivation for materials discovery, is well illustrated by the prevalence of surface modification of polymers in an attempt to achieve the required surface properties [35][36][37][38][39][40][41][42][43][44][45][46][47]. The creation of a diverse range of polymeric materials is an important requirement for producing biomaterials ideally suited to the unique and specific requirements of every medical application [20].…”

Section: Introductionmentioning

confidence: 99%

High throughput methods applied in biomaterial development and discovery

et al. 2010

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The high throughput discovery of new materials can be achieved by rapidly screening many different materials synthesised by a combinatorial approach to identify the optimal material that fulfils a particular biomedical application. Here we review the literature in this area and conclude that for polymers, this process is best achieved in a microarray format, which enable thousands of cell-material interactions to be monitored on a single chip. Polymer microarrays can be formed by printing pre-synthesised polymers or by printing monomers onto the chip where on-slide polymerisation is initiated.The surface properties of the material can be analysed and correlated to the biological performance using high throughput surface analysis, including time-of-flight secondary ion mass spectrometry (ToF-SIMS), Xray photoelectron spectroscopy (XPS) and water contact angle (WCA) measurements. This approach enables the surface properties responsible for the success of a material to be understood, which in turn provides the foundations of future material design. The high throughput discovery of materials using polymer microarrays has been explored for many cell-based applications including the isolation of specific 2 cells from heterogeneous populations, the attachment and differentiation of stem cells and the controlled transfection of cells.Further development of polymerisation techniques and high throughput biological assays amenable to the polymer microarray format will broaden the combinatorial space and biological phenomenon that polymer microarrays can explore, and increase their efficacy. This will, in turn, result in the discovery of optimised polymeric materials for many biomaterial applications.

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“…Collagen is one of biocompatible polymer materials, which can be used to prepare adsorption film (Lee et al 2001). For mechanical stability, the adsorption film must be prepared using a suitable material.…”

Section: Introductionmentioning

confidence: 99%

Modification of fish skin collagen film and absorption property of tannic acid

et al. 2011

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Fish collagen is a biomacromolecule material and is usually used as a clarifying agent. However, fish collagen is not recyclable, and sedimentation usually occurs in the clarification process using fish collagen so that the filtration process is inevitable. This work aimed to provide a recyclable modified fish skin collagen film (MFCF) for adsorption of tannic acids. The collagen from channel catfish skin was extracted and used for preparation of the fish skin collagen film (FCF) and MFCF. The result indicated that the mechanical properties of MFCF were improved by addition of 2 ml/L glycerol, 6 ml/L polyvinyl alcohol (PVA) and 2 ml/L glutaraldehyde in 15 g/L collagen solution. As the most important property of adsorption material, the hydroscopicity of MFCF was only 54%, significantly lower than that of FCF (295%). Therefore, MFCF would not collapse in water. The infrared and thermal properties of MFCF were also investigated in this work. Results indicated that, in comparison to FCF, the physical and chemical properties of MFCF had been improved significantly. MFCF had higher shrink temperature (79.3°C) and it did not collapse in distilled water at normal temperature. Furthermore, absorption and desorption properties of tannic acid were studied. MFCF showed good capability of absorption and desorption of tannic acid, which leaded to the suggestion that MFCF could have potential applications in adsorption material.

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Biomedical applications of collagen

Cited by 1,653 publications

References 161 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

High throughput methods applied in biomaterial development and discovery

Modification of fish skin collagen film and absorption property of tannic acid

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