Biomedical Applications

and, Wolfgang Frieß; Warner, Jan

doi:10.1002/9783527618286.ch39

Cited by 6 publications

(5 citation statements)

References 196 publications

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“…They may have control over the size and shape of the pores; 21,22 however, they do not provide any control over the connection patterns, often leaving blind ends in the implants and producing interconnections much smaller than the pores. 23 The solid freeform fabrication (SFF) techniques, also known as rapid prototyping techniques, have significant advantages for fabricating scaffolds over conventional, manual-based fabrication methods. The SFF techniques are computerized fabrication techniques that can rapidly produce highly complex three-dimensional objects using computer-controlled tools, based on 2D cross-sectional data obtained from slicing a computer-aided-design model of the object.…”

Section: Introductionmentioning

confidence: 99%

“…However, all these methods provide minimal control over the internal architecture of the implants. They may have control over the size and shape of the pores;21, 22 however, they do not provide any control over the connection patterns, often leaving blind ends in the implants and producing interconnections much smaller than the pores 23…”

Section: Introductionmentioning

confidence: 99%

“…The beams which will generate the porous structures having around 400 μm of diameter. This size, according to the bibliography,23 should be large enough for the bone ingrowths and vascularization. The scaffold is produced casting a homogeneous suspension of the glass into the molds which are afterwards polymerized.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive glass as precursor of designed‐architecture scaffolds for tissue engineering

Padilla

Sánchez‐Salcedo

Vallet‐Regí

2006

J Biomedical Materials Res

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In this work, the conditions to obtain concentrated and fluid suspensions from a bioactive glass (55-SiO(2); 41-CaO; 4-P(2)O(5); mol %) were investigated. The influence of the heat treatment of the glass on the specific surface area, solubility, bioactivity, and finally on their dispersion characteristics was studied. Zeta potential and viscosity measurements were carried out, and based on the obtained results, the best dispersant was selected. The optimum concentration of dispersant, maximum content of solid and time of mixing were also investigated. Slurries containing 50 vol % could be obtained calcining the glass at 1100 degrees C and using Darvan 811 (sodium polyacrylate) as dispersant. Scaffolds with designed architecture were prepared from these suspensions combining the gelcasting method and the stereolithography technique. A polymeric negative (replica of the desired structure) was previously obtained by stereolithography. The slurry was cast into the molds and then polymerized (gelcasting method). The negative was eliminated by heat treatment. After sintering at 1300 degrees C, scaffolds with interconnected porosity and three-dimensional channels of 400-470 microm and macropores of 1.4 microm were obtained.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioactive glass as precursor of designed‐architecture scaffolds for tissue engineering

Padilla

Sánchez‐Salcedo

Vallet‐Regí

2006

J Biomedical Materials Res

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“…However, it has been very challenging to fabricate geometrically complex porous ceramic structures with these manufacturing technologies. Gelcasting method is the technique which leads to a high structural uniformity, good homogeneity, minimized defects and high density of the ceramic matrix, as well as complex shapes and tailored geometry, etc [7][8][9]. Gel-casted parts can also be machined into more complex shapes on biological application point of view when necessary.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Porous Silica Ceramics Prepared Using Rice Husk Ash by Gelcasting Method

Nayak¹,

Bera²

2012

AMR

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Silica-based porous bioactive ceramics was prepared by gel-casting method using silica xerogel powder. Xerogel was derived from rice husk ash. 42 vol.% solid containing slurry was prepared in 1:30 (MBAM:AM) monomer cross-linker solution. The srurry was thixotropic. Gel-casted body was machined efficiently. Dired cast body was sintered at 1100oC. Apatite layer was formed on silica body during In vitro bioactivity experiment. The results suggest that the gel-casted silica ceramics can be used as a bioceramics.

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“…Membranes [2,3] find application in biotechnology, food processing, pharmaceutical, petro-chemical, electronics; improvement of the thermo-mechanical properties while lowering production costs is necessary for further expansion of the applications. In the biomedical field [4] porous ceramics (hydroxyapatite) find use in bone replacement and drug delivery systems [5]; because of its excellent biocompatibility, it enables the production of architectures similar to those of real bones, and has the potential to repair the defects through a complete penetration of the osseous tissue [6].…”

Section: Introductionmentioning

confidence: 99%

A Technique for the Preparation of Porous Ceramic Materials by Gelcasting Method

Huang

Cheng²,

Tong

et al. 2010

AMR

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A technique for the preparation of porous ceramic materials by gelcasting mothod is studied using a water-soluble epoxy resin combined with a amine hardener. The increase in the volume and rheological behavior of slurry , TGA and DSC of the green bodies are investigated. The influence of solid content on the relative density, the cell size distribution and the compressive strenghth is studied. The experimental results show that in the measurable shear rate range the rheology of slurry exhibt a shear thinning behavior, the relative density increase with the solid content, with the decrease of the relative densities the cell size increase. The compressive strength increased exponentially with the increase relative density, and the exponent, m, is 1.094.

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Biomedical Applications

Cited by 6 publications

References 196 publications

Bioactive glass as precursor of designed‐architecture scaffolds for tissue engineering

Bioactive glass as precursor of designed‐architecture scaffolds for tissue engineering

Bioactive Porous Silica Ceramics Prepared Using Rice Husk Ash by Gelcasting Method

A Technique for the Preparation of Porous Ceramic Materials by Gelcasting Method

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