Biomechanics of Skeletal Muscle and Tendon

Chao, Yuan-Hung; Sun, Jui‐Sheng

doi:10.1007/978-981-15-3159-0_2

Cited by 2 publications

(2 citation statements)

References 163 publications

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“…In bone, groups of five triple helical collagen molecules form microfibrils. The microfibrils are spontaneously organized into fibrils and fibers that can be up to 1 cm in length and 1 mm in diameter and with the characteristic 67 nm banding feature, called the D-period [ 31 , 32 ]. The hydroxyapatite (HA) nanocrystals are deposited by osteoblasts on the collagen fibrils, constituting the inorganic and organic phases of the bone matrix.…”

Section: Collagen In Native Bone Tissuesmentioning

confidence: 99%

The Use of Collagen-Based Materials in Bone Tissue Engineering

Fan

Ren

Emmert

et al. 2023

IJMS

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Synthetic bone substitute materials (BSMs) are becoming the general trend, replacing autologous grafting for bone tissue engineering (BTE) in orthopedic research and clinical practice. As the main component of bone matrix, collagen type I has played a critical role in the construction of ideal synthetic BSMs for decades. Significant strides have been made in the field of collagen research, including the exploration of various collagen types, structures, and sources, the optimization of preparation techniques, modification technologies, and the manufacture of various collagen-based materials. However, the poor mechanical properties, fast degradation, and lack of osteoconductive activity of collagen-based materials caused inefficient bone replacement and limited their translation into clinical reality. In the area of BTE, so far, attempts have focused on the preparation of collagen-based biomimetic BSMs, along with other inorganic materials and bioactive substances. By reviewing the approved products on the market, this manuscript updates the latest applications of collagen-based materials in bone regeneration and highlights the potential for further development in the field of BTE over the next ten years.

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Section: Collagen In Native Bone Tissuesmentioning

confidence: 99%

The Use of Collagen-Based Materials in Bone Tissue Engineering

Fan

Ren

Emmert

et al. 2023

IJMS

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show abstract

“…Maturation is characterized by the removal of non-collagenous propeptides by procollagen amino and carboxy proteases, originating an alpha chain measuring 1.25 nm wide and 300 nm long with a mass of 285 kDa [22]. Five of these parallel chains form a microfibril 1 cm long and 1 mm in diameter with 67 nm bands, where the deposition of hydroxyapatite, the main inorganic constituent of the osteoid matrix secreted by osteoblasts, subsequently occurs [23]. Despite significant advances in collagen synthesis and purification processes, there is still no scaffold that fully reproduces the properties of the native protein; there are some minimal differences remaining in its structure [24] and it is susceptible to hydrolytic and enzymatic degradation if it comes into contact with body fluid [25].…”

Section: Introductionmentioning

confidence: 99%

Viability of Collagen Matrix Grafts Associated with Nanohydroxyapatite and Elastin in Bone Repair in the Experimental Condition of Ovariectomy

de Moraes,

Plepis,

Martins

et al. 2023

IJMS

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Bone lesions have the capacity for regeneration under normal conditions of the bone metabolism process. However, due to the increasing incidence of major traumas and diseases that cause bone-mineral deficiency, such as osteoporosis, scaffolds are needed that can assist in the bone regeneration process. Currently, natural polymeric scaffolds and bioactive nanoparticles stand out. Therefore, the objective of the study was to evaluate the osteoregenerative potential in tibiae of healthy and ovariectomized rats using mineralized collagen and nanohydroxyapatite (nHA) scaffolds associated with elastin. The in-vivo experimental study was performed with 60 20-week-old Wistar rats, distributed into non-ovariectomized (NO) and ovariectomized (O) groups, as follows: Controls (G1-NO-C and G4-O-C); Collagen with nHA scaffold (G2-NO-MSH and G5-O-MSH); and Collagen with nHA and elastin scaffold (G3-NO-MSHC and G6-O-MSHC). The animals were euthanized 6 weeks after surgery and the samples were analyzed by macroscopy, radiology, and histomorphometry. ANOVA and Tukey tests were performed with a 95% CI and a significance index of p < 0.05. In the histological analyses, it was possible to observe new bone formed with an organized and compact morphology that was rich in osteocytes and with maturity characteristics. This is compatible with osteoconductivity in both matrices (MSH and MSHC) in rats with normal conditions of bone metabolism and with gonadal deficiency. Furthermore, they demonstrated superior osteogenic potential when compared to control groups. There was no significant difference in the rate of new bone formation between the scaffolds. Ovariectomy did not exacerbate the immune response but negatively influenced the bone-defect repair process.

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Biomechanics of Skeletal Muscle and Tendon

Cited by 2 publications

References 163 publications

The Use of Collagen-Based Materials in Bone Tissue Engineering

The Use of Collagen-Based Materials in Bone Tissue Engineering

Viability of Collagen Matrix Grafts Associated with Nanohydroxyapatite and Elastin in Bone Repair in the Experimental Condition of Ovariectomy

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