Biomechanics of abdominal aortic aneurysm in the presence of endoluminal thrombus: Experimental characterisation and structural static computational analysis

Martino, Elena S. Di; Mantero, Sara; Inzoli, Fabio; Melissano, Germano; Astore, D.; Chiesa, Roberto; Fumero, R.

doi:10.1016/s1078-5884(98)80031-2

Cited by 167 publications

(158 citation statements)

References 19 publications

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“…16,52 Di Martino et al have shown that the presence of ILT can significantly reduce wall stresses. [12][13][14][15] Fluid-structure interaction (FSI) simulations, in which a fully coupled dynamic interaction between the AAA hemodynamics and wall deformations is modeled, were conducted by our group and others to simulate the biomechanical behavior of the AAA wall. 3,14,18,36,48,60 Most previous FSI studies were based on isotropic material models that exclude the directional response of abdominal aortic tissue to stresses.…”

Section: Computational Simulations and Fluid-structure Interaction Momentioning

confidence: 99%

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Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

et al. 2010

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Abstract-Elective repair of abdominal aortic aneurysm (AAA) is warranted when the risk of rupture exceeds that of surgery, and is mostly based on the AAA size as a crude rupture predictor. A methodology based on biomechanical considerations for a reliable patient-specific prediction of AAA risk of rupture is presented. Fluid-structure interaction (FSI) simulations conducted in models reconstructed from CT scans of patients who had contained ruptured AAA (rAAA) predicted the rupture location based on mapping of the stresses developing within the aneurysmal wall, additionally showing that a smaller rAAA presented a higher rupture risk. By providing refined means to estimate the risk of rupture, the methodology may have a major impact on diagnostics and treatment of AAA patients.

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Section: Computational Simulations and Fluid-structure Interaction Momentioning

confidence: 99%

“…The ILT material was modeled as linear elastic with a Young's modulus of 0.11 MPa and a Poisson ratio of 0.45. 13,36 Microcalcifications were assumed to behave as a stiff isotropic material with properties summarized in Table 2.…”

Section: Materials Properties Of the Aortic Wallmentioning

confidence: 99%

Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

et al. 2010

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“…However, very recently [7] and [3] reported extensive studies on the material properties of thrombus. The mean thrombus shear modulus that they found (1.7 ± 1.3 kPa) is much lower than the values assumed in [9,48], the role of thrombus in wall-stress analysis may therefore be overestimated. The elasticity of thrombus is several orders higher than that of the vessel wall [6], which may mean that thrombus could be neglected during the wall-stress simulations.…”

Section: Wall-stress Modelingmentioning

confidence: 56%

“…Intraluminal thrombus has been incorporated in the finite-element models in several other studies [9,21,48]. In [48] and [9] a significant influence was reported of thrombus on the outcome of the stress calculations. However, very recently [7] and [3] reported extensive studies on the material properties of thrombus.…”

Section: Wall-stress Modelingmentioning

confidence: 99%

Towards patient-specific risk assessment of abdominal aortic aneurysm

Breeuwer

Putter

Kose

et al. 2008

Med Biol Eng Comput

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Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers)Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication Citation for published version (APA):Breeuwer, M., Putter, de, S., Kose, U., Speelman, L., Visser, K., Gerritsen, F. A., ... Vosse, van de, F. N. (2008). Towards patient-specific risk assessment of abdominal aortic aneurysm. Medical and Biological Engineering and Computing, 46(11), 1085-1095. DOI: 10.1007/s11517-008-0393-0 General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Abstract Diagnosis of vascular disease and selection and planning of therapy are to a large extent based on the geometry of the diseased vessel. Treatment of a particular vascular disease is usually considered if the geometrical parameter that characterizes the severity of the disease, e.g. % vessel narrowing, exceeds a threshold. The thresholds that are used in clinical practice are based on epidemiological knowledge, which has been obtained by clinical studies including large numbers of patients. They may apply ''on average'', but they can be sub-optimal for individual patients. To realize more patient-specific treatment decision criteria, more detailed knowledge may be required about the vascular hemodynamics, i.e. the blood flow and pressure in the diseased vessel and the biomechanical reaction of the vessel wall to this flow and pressure. Over the last decade, a substantial number of publications have appeared on hemodynamic modeling. Some studies have provided first evidence that this modeling may indeed be used to support therapeutic decisions. The goal of the research reported in this paper is to go one step further, namely to investigate the feasibilit...

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“…Di Martino et al 19) performed an experimental and structural static computational analysis of the biomechanics, and reported that a well-organized thrombus can decrease the pressure load of the aortic aneurismal wall. Using axisymmetric finite element analysis, Mower et al 20) also reported that an intraluminal thrombus could decrease wall stress within an abdominal aortic aneurysm.…”

Section: Intra-luminal Thrombosismentioning

confidence: 99%

Radiological Imaging of Aortic Aneurysms

Lee

2007

Korean Circ J

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The development of radiological equipment such as MDCT or ultrasonography has increased the diagnostic accuracy of aortic aneurysms and has allowed for improvements in surgical and interventional treatment techniques. However, the mortality and morbidity rate of aortic aneurysms has not decreased significantly. For this reason, there is continuous interest in radiological evaluations of aortic aneurysms. This report reviews the radiological image findings and useful indications for both the diagnosis and surveillance of aortic aneurysms. The popular radiological features of an aortic aneurysm are aortic expansion, combined atherosclerosis, intraluminal mural thrombus, perianeurysmal inflammation and fibrosis, and perianeurysmal hemorrhage due to rupture. As rupture is the most important complication of an aortic aneurysm, various signs of an impending rupture have been suggested. These include the following: a maximum aneurysmal diameter larger than the threshold value, a high expansion rate, periaortic sentinel hemorrhage, and a hyperattenuating crescent in the mural thrombus or aneurysmal wall. To acknowledge the impending rupture of an aortic aneurysm, careful depiction of the clues is indispensable. (Korean Circulation J 2007;37:337-347)

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Biomechanics of abdominal aortic aneurysm in the presence of endoluminal thrombus: Experimental characterisation and structural static computational analysis

Abstract: Well organised thrombus reduces the effect of the pressure load on the aneurysmal aortic wall.

Cited by 167 publications

References 19 publications

Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

Towards patient-specific risk assessment of abdominal aortic aneurysm

Radiological Imaging of Aortic Aneurysms

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