Towards patient-specific risk assessment of abdominal aortic aneurysm

Abstract

Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers)Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication Citation for published version (APA):Breeuwer, M., Putter, de, S., Kose, U., Speelman, L., Visser, K., Gerritsen, F. A., ... Vosse, van de, F. N. (2008). Towards patient-specific risk assessment of abdominal aortic aneurysm. Medical and Biological Engineering and Computing, 46(11), 1085-1095. DOI: 10.1007/s11517-008-0393-0 General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Abstract Diagnosis of vascular disease and selection and planning of therapy are to a large extent based on the geometry of the diseased vessel. Treatment of a particular vascular disease is usually considered if the geometrical parameter that characterizes the severity of the disease, e.g. % vessel narrowing, exceeds a threshold. The thresholds that are used in clinical practice are based on epidemiological knowledge, which has been obtained by clinical studies including large numbers of patients. They may apply ''on average'', but they can be sub-optimal for individual patients. To realize more patient-specific treatment decision criteria, more detailed knowledge may be required about the vascular hemodynamics, i.e. the blood flow and pressure in the diseased vessel and the biomechanical reaction of the vessel wall to this flow and pressure. Over the last decade, a substantial number of publications have appeared on hemodynamic modeling. Some studies have provided first evidence that this modeling may indeed be used to support therapeutic decisions. The goal of the research reported in this paper is to go one step further, namely to investigate the feasibilit...

The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm

“…The geometry of the AAA was segmented from the CTA scan using software developed by Philips Healthcare (Best, The Netherlands) in collaboration with University Medical Center Utrecht, Philips Healthcare Research (Paris, France), Eindhoven University of Technology, and our group. [24][25][26][27][28][29] A start point in the flow lumen at the level of the renal arteries and two endpoints just distal to the aortic bifurcation needed to be selected by the user. The centerline of the AAA was tracked automatically between the three points by means of a minimal cost path approach.…”

Initial stress and nonlinear material behavior in patient-specific AAA wall stress analysis

“…The CT-data was processed using an automatic segmentation procedure that has been developed by Philips Healthcare (Best, the Netherlands) in collaboration with University Medical Center Utrecht, Philips Healthcare Research (Paris, France) and our group (de Putter et al, 2007;Delingette, 1994;Ollabarriaga et al, 2005;Breeuwer et al, 2008). The segmentation procedure requires the placement of three user points in the flow lumen of the AAA, which are the starting point at the level of the renal arteries and two endpoints in both iliac arteries just distal to the aortic bifurcation.…”

“…Manual corrections were allowed by adapting slice contours when the automatic segmentation lacked accuracy. Further details on the segmentation process are described by Breeuwer et al (2008).…”

The effect of angulation in abdominal aortic aneurysms: fluid–structure interaction simulations of idealized geometries

“…Breeuwer et al investigated the feasibility of a patient-based hemodynamic modeling of AAA. This methodology is an efficient (improved therapeutic decision) and a robust (insensitive to variation in the quality of input data) approach to risk assessment of AAA [8].…”