Biomechanical testing of bioactive bone cements – a comparison of the impact of modifiers: antibiotics and nanometals

Wekwejt, Marcin; Moritz, Niko; Świeczko-Żurek, Beata; Pałubicka, Anna

doi:10.1016/j.polymertesting.2018.07.014

Cited by 19 publications

(23 citation statements)

References 35 publications

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“…The rejection of long-term implants observed during the primary and long-term fixation period has resulted in the development of a variety of antibacterial titanium surfaces for titanium implants, with the most popular including Ag, Cu, Zn, F, Y, Fe, N, Co, antibiotics, chitosan, and peptides [2,3]. Silver is used in medical applications as pure metallic silver, silver halides, nitrate, and sulfate, silver-organic complexes and silver zeolite, silver oxide nanoparticles, and silver ions [4][5][6]. Silver nanoparticles (AgNPs) cause damage to the bacterial membrane and subcellular structures, dependent on the shape, size, surface appearance, and chemical states, and aggregation of the AgNPs [7].…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

et al. 2020

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The surface treatment of titanium implants has been applied mainly to increase surface bioactivity and, more recently, to introduce antibacterial properties. To this end, composite coatings have been investigated, particularly those based on hydroxyapatite. The present research was aimed at the development of another coating type, chitosan–nanosilver, deposited on a Ti13Zr13Nb alloy. The research comprised characterization of the coating’s microstructure and morphology, time-dependent nanosilver dissolution in simulated body fluid, and investigation of the nanomechanical properties of surface coatings composed of chitosan and nanosilver, with or without a surface-active substance, deposited at different voltages for 1 min on a nanotubular TiO2 layer. The microstructure, morphology, topography, and phase composition were examined, and the silver dissolution rate in simulated body fluid, nanoscale mechanical properties, and water contact angle were measured. The voltage value significantly influenced surface roughness. All specimens possessed high biocompatibility. The highest and best adhesion of the coatings was observed in the absence of a surface-active substance. Silver dissolution caused the appearance of silver ions in solution at levels effective against bacteria and below the upper safe limit value.

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Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

et al. 2020

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“…A thorough assessment of the biomechanical properties of bone cements modified with nanometals or antibiotic was carried out in the previous study (Wekwejt et al, ). In this research, for general estimation of mechanical properties of the obtained cements, microhardness measurements were made.…”

Section: Resultsmentioning

confidence: 99%

“…In the case of infection risk, the use of bioactive cement (with an antibiotic or nanometals) is suggested. On the basis of own research and literature (Miola et al, ; Moojen et al, ; Paiva et al, ; Petrochenko et al, ; Slane et al, ; Świeczko‐Żurek, ; Wekwejt et al, ), the following conclusions have been drawn: antibiotics worsen the mechanical properties, while nanometals have no negative effect on them; in the case of antibiotics, there is a problem of bacterial resistance and lack of therapeutic efficacy; however, in the case of nanometals, dose selection is crucial because of their cytotoxicity. Moreover, a significant problem in both cases is to provide a long period of protection, which depends on the release of the active substance.…”

Section: Discussionmentioning

confidence: 99%

“…The average size of a nanoparticle was 90 nm and its purity was 99.9%. The cements were prepared following the procedure by the manufacturer's recommendation (Tecres, ), but the preparation of modified cements was conducted with a preceding step, in accordance with previous study (Świeczko‐Żurek, ; Wekwejt et al, ). First, the powder was aerated (mixing for 1 min) and then the modifier was added to it.…”

Section: Methodsmentioning

confidence: 99%

“…The mixture was mixed for 1 min by hand with an average speed—2 rev/s. The concentration of the modification had been chosen based on the preliminary results of the previous research (Wekwejt et al, ). The final composition of bone cement used in this work is presented in Table .…”

Section: Methodsmentioning

confidence: 99%

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Implant system for treatment of the orbital floor defects of blowout fractures in the maxillofacial region using polypropylene yarn and bioactive bone cement

et al. 2020

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Fractures in the craniofacial region are a serious problem in terms of treatment. The most reasonable solution is the use of individual implants dedicated to a specific patient. The aim of this study was to develop the implant system specifically for treatment of the orbital floor defects of blowout fractures of maxillofacial region, using polypropylene yarn and bone cement. Three types of bone cement were used to fix the polypropylene yarn: unmodified, antibiotic‐loaded, and modified with nanometals. The following research was carried out: selection of cement production parameters, assessment of the curing time, measurement of polymerization temperature, an analysis of microstructure and surface topography, evaluation of wettability, measurement of microhardness, and studies of bactericidal effectiveness. The research confirms the possibility of using bone cement and polypropylene yarn for an individual implant, dedicated to the fractures treatment in the maxillofacial region. Moreover, the bactericidal properties of the proposed modifications for bone cement have been verified; hence, bioactive cements are recommended for use in the case of infectious complications.

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Poly(methyl methacrylate) bone cement, its rise, growth, downfall and future

Bakhtiari

Bakhsheshi-Rad

Karbasi

et al. 2020

Polymer International

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Poly(methyl methacrylate) (PMMA)‐based bone cements (BCs) can be defined as a family of materials that consist of powder and liquid phases which after mixing form a plastic paste that can self‐set once implanted in the human body. PMMA‐based BCs are easily molded and adapted to complex bone cavities or used in orthodontic applications to restore dental damage. The main advantages of the use of cement are the excellent primary fixation between bone and implant and, therefore, the faster recovery of the patient. Despite the initial success rate of implant fixation with BCs, they have some disadvantages such as local tissue damage due to exothermic polymerization reactions, mechanical mismatch between native bone and cement, lack of bone regeneration and bioactivity and poor mechanical properties which may cause the failure of the BCs. BCs are still considered as a top option for bone repair. Due to the disadvantages highlighted, research has focused on alternative materials used with PMMA‐based BCs. This review aims to critically review the BCs and emerging materials used in combination with PMMA‐based BCs. These materials include titania, apatite–wollastonite (A‐W), glass ceramic (GC) and hydroxyapatite (HA). The review discusses the properties of these materials and their pathway to clinical study. Among the various kinds of reinforcement, HA has been extensively used. So, in this review, we compare the effects of HA as reinforcement in PMMA‐based BCs. Upcoming study of PMMA‐based BCs should concentrate on trialing combinations of these reinforcing agents as this might improve beneficial characteristics. © 2020 Society of Industrial Chemistry

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Biomechanical testing of bioactive bone cements – a comparison of the impact of modifiers: antibiotics and nanometals

Cited by 19 publications

References 35 publications

Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer

Implant system for treatment of the orbital floor defects of blowout fractures in the maxillofacial region using polypropylene yarn and bioactive bone cement

Poly(methyl methacrylate) bone cement, its rise, growth, downfall and future

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