Biomechanical research into lamina cribrosa in glaucoma

Li, Long; Song, Fan

doi:10.1093/nsr/nwaa063

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…В результате сложных каскадных реакций происходит ремоделирование коллагена РМС и окружающей ее перипапиллярной склеры [31,32]. Следствием является деформация мембраны и ущемление проходящих через ее отверстия пучков нервных волокон и сосудов (рис.…”

Section: теория трансмембранного градиента давления в патогенез гндunclassified

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Review. Part 1

Kurysheva,

Kim,

Plieva

et al. 2023

Oftalʹmologiâ

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In the modern world, glaucoma is one of the main causes of irreversible vision loss. Normal tension glaucoma (NTG) constitutes the major proportion of POAG, which is common in Asian populations. NTG is a disease resulted from the interaction of multiple genetic risk factors. But other factors are also important, such as thinning of the scleral lamina cribrosa and a lesion of the transmembrane pressure gradient. Central visual field defects and disc hemorrhage are characteristics finding that is highly associated with the progression of NTG.

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Section: теория трансмембранного градиента давления в патогенез гндunclassified

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Review. Part 1

Kurysheva,

Kim,

Plieva

et al. 2023

Oftalʹmologiâ

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“…The perforated lamina cribrosa (LC) is the weakest part of the sclera, and it is where the RGC axons pierce through the minute perforations to form the optic nerve, while the central retinal artery and vein pass through the LC via a larger central aperture [15]. Elevated IOP resulted from the imbalance between the production and drainage of aqueous humor, which led to the irreversible backwards bowing of the LC, in the process known as 'cupping' [16]. Optic nerve cupping is characterized by the remodeling of the extracellular matrix (ECM) and fibrosis in the LC [17].…”

Section: Mechanical Hypothesismentioning

confidence: 99%

“…Glaucomatous LC cells showed increased ECM gene expression and elevated intracellular calcium, which is known to promote proliferation, activation and contractility in fibroblasts via the nuclear factor of activated T cells/calcium signaling pathway [17]. This deformation damages the optic nerve and capillaries passing through the LC, disturbing the anterograde axonal transportation of RGCs, which then ultimately triggers visual field defects in glaucoma [16]. Furthermore, elevated IOP also resulted in activated pro-fibrotic pathway-induced ECM accumulation in the TM, leading to less efficient aqueous humor outflow, thereby causing further damage to the LC [18].…”

Section: Mechanical Hypothesismentioning

confidence: 99%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

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Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. In addition to mechanical and vascular dysfunctions of the eye, oxidative stress, neuroinflammation and excitotoxicity have also been implicated in the pathogenesis of glaucoma. Hence, the use of natural products with antioxidant and anti-inflammatory properties may represent an alternative approach for glaucoma treatment. The present review highlights recent preclinical and clinical studies on various natural products shown to possess neuroprotective properties for retinal ganglion cells, which thereby may be effective in the treatment of glaucoma. Intraocular pressure can be reduced by baicalein, forskolin, marijuana, ginsenoside, resveratrol and hesperidin. Alternatively, Ginkgo biloba, Lycium barbarum, Diospyros kaki, Tripterygium wilfordii, saffron, curcumin, caffeine, anthocyanin, coenzyme Q10 and vitamins B3 and D have shown neuroprotective effects on retinal ganglion cells via various mechanisms, especially antioxidant, anti-inflammatory and anti-apoptosis mechanisms. Extensive studies are still required in the future to ensure natural products’ efficacy and safety to serve as an alternative therapy for glaucoma.

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“…Glaucoma is now recognized as a group of progressive optic neuropathies characterized by excavation or cupping of the optic disc and corresponding visual field loss ( 3 , 4 ). Elevated intraocular pressure (IOP), a major risk factor for the development and progression of glaucoma, is considered to impair the lamina cribrosa, resulting in a loss of normal structural and metabolic support for retinal ganglion cell (RGC) axon and impaired axoplasmic transport ( 5 – 7 ) ( Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%

Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)

Xia,

Zhang

2024

Mol Med Rep

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Glaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase-protein kinase B or other medicines can rescue pathological changes in glaucoma. Due to the complex crosstalk of apoptosis pathways, the pathophysiological mechanism of apoptosis in glaucoma needs to be fully elucidated. The present review aimed to discuss the mechanism of cell apoptosis in glaucoma, improve the understanding of the pathophysiology of glaucoma, summarize new directions for the treatment of glaucoma and lay the foundation for new treatment strategies for glaucoma.

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Biomechanical research into lamina cribrosa in glaucoma

Cited by 8 publications

References 14 publications

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Review. Part 1

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Review. Part 1

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)

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