Biomechanical evaluation of a titanium implant surface conditioned by a hydroxide ion solution

Stadlinger, Bernd; Ferguson, Stephen J.; Eckelt, Uwe; Mai, Roland; Lode, Anna Theresa; Loukota, R.A.; Schlottig, Falko

doi:10.1016/j.bjoms.2010.11.013

Cited by 36 publications

(20 citation statements)

References 17 publications

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“…Some of these surfaces have previously been described to display increased osseointegration in animal models under compromised osteoporotic conditions. We utilised aged rats, which were oestrogen-deprived by ovariectomy, as a standard model for the simulation of post-menopausal osteoporosis (Thompson et al, 1995). Following ovariectomy, bone resorption exceeds bone formation, increasing bone turnover and inducing rapid cancellous bone loss resulting in a severely rarefied trabecular network within three months (Jee and Yao, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…The conditioning by hydroxide ions influences surface charge, hydrophilicity and the homogeneity of the initial protein layer (Tugulu et al, 2010). Various animal studies utilising non-osteoporotic conditions have analysed mechanics and histomorphometry of such conditioned implants, and demonstrated increased bone formation and removal torque values indicating improved osseointegration (Ferguson et al, 2006;Calvo-Guirado et al, 2010;Stadlinger et al, 2012). However, in our setting, we observed -neither in osteoporotic oestrogen deprived nor in non-osteoporotic oestrogen-competent animalsan increase of bone-implant contact or an improvement of biomechanical properties in comparison to reference Significantly different (p ≤ 0.05) compared to reference in non-OVX (*) or OVX (#) rats at the same time point; equal number of animals (n) for both parameters.…”

Section: Discussionmentioning

confidence: 99%

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Osseointegration of biochemically modified implants in an osteoporosis rodent model

Stadlinger

Korn

Tödtmann

et al. 2013

eCM

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The present study examined the impact of implant surface modifications on osseointegration in an osteoporotic rodent model. Sandblasted, acid-etched titanium implants were either used directly (control) or were further modified by surface conditioning with NaOH or by coating with one of the following active agents: collagen/chondroitin sulphate, simvastatin, or zoledronic acid. Control and modified implants were inserted into the proximal tibia of aged ovariectomised (OVX) osteoporotic rats (n = 32/group). In addition, aged oestrogen competent animals received either control or NaOH conditioned implants. Animals were sacrificed 2 and 4 weeks post-implantation. The excised tibiae were utilised for biomechanical and morphometric readouts (n = 8/group/readout). Biomechanical testing revealed at both time points dramatically reduced osseointegration in the tibia of oestrogen deprived osteoporotic animals compared to intact controls irrespective of NaOH exposure. Consistently, histomorphometric and microCT analyses demonstrated diminished bone-implant contact (BIC), periimplant bone area (BA), bone volume/tissue volume (BV/ TV) and bone-mineral density (BMD) in OVX animals. Surface coating with collagen/chondroitin sulphate had no detectable impact on osseointegration. Interestingly, statin coating resulted in a transient increase in BIC 2 weeks post-implantation; which, however, did not correspond to improvement of biomechanical readouts. Local exposure to zoledronic acid increased BIC, BA, BV/TV and BMD at 4 weeks. Yet this translated only into a non-significant improvement of biomechanical properties. In conclusion, this study presents a rodent model mimicking severely osteoporotic bone. Contrary to the other bioactive agents, locally released zoledronic acid had a positive impact on osseointegration albeit to a lesser extent than reported in less challenging models.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Osseointegration of biochemically modified implants in an osteoporosis rodent model

Stadlinger

Korn

Tödtmann

et al. 2013

eCM

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“…8,9 During the interaction of cells and interface, the wettability of the surface could inuence the adhesion of the proteins and other macromolecules on the surface, the cluster formation of osteoblast and osteogenic gene expression in vitro, as well as the rate of osseointegration in vivo. 17,20,21 Besides sodium hydroxide, other kinds of alkalis are also candidates for such modication. in vitro.…”

Section: Introductionmentioning

confidence: 99%

The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro

Jia

et al. 2015

RSC Adv.

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Achieving fast and long-term osseointegration is one of the major goals in dental implant design. Physicchemical surface modification is a key to osseointegration improvement. Two types of alkaline modifications, 1 M sodium bicarbonate and 0.05 M sodium hydroxide, were applied on the sand-blasting and acid etching (SLA) titanium surface. After the alkaline treatments, superhydrophilic SLA surfaces were produced. The mRNA expression level of IL-1b of Raw264.7 cells cultured on the sodium bicarbonate treated SLA surface was inhibited compared with SLA and sodium hydroxide treated surfaces, while MMP-9 expression on the sodium hydroxide treated SLA surface was increased with comparison to SLA and sodium bicarbonate treated surfaces. Cell adhesion of osteoblast-like MG63 cells on surfaces with alkaline treatments were moderately more pronounced than that on the SLA surface. With comparison to SLA surface, the proliferation of MG63 cells was decreased, while the alkaline phosphatase (ALP) activity was enhanced on the sodium bicarbonate treated SLA surface after 3 days. An increased mRNA expression level of integrin a v of MG63 cells were observed on the alkali treated surfaces compared with the SLA surface. Integrin b 1 , osteocalcin (OCN) and bone morphogenetic protein-2 (BMP-2) were enhanced on the sodium bicarbonate treated SLA surface when compared to the SLA surface. The results imply that the inflammation-related gene expression of macrophage cells is changed on sodium hydroxide and sodium bicarbonate treated SLA surfaces; the early adhesion of osteoblast-like cells is enhanced by both alkaline treatments, while the osteogenic differentiation is improved on sodium bicarbonate treated surface.

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“…In cases where good mechanical characteristics are required as in hip implants, knee implants, bone screws, and plates, Ti-6Al-4V alloy is being used [27] [28]. One of the most common applications of titanium alloys is artificial hip joints that consist of an articulating bearing (femoral head and cup) and stem [24], where metallic cup and hip stem components are made of titanium.…”

Section: Tribology -Fundamentals and Advancementsmentioning

confidence: 99%

Titanium and Titanium Alloys as Biomaterials

Viteri¹,

Fuentes²

2013

Tribology - Fundamentals and Advancements

100

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Biomechanical evaluation of a titanium implant surface conditioned by a hydroxide ion solution

Cited by 36 publications

References 17 publications

Osseointegration of biochemically modified implants in an osteoporosis rodent model

Osseointegration of biochemically modified implants in an osteoporosis rodent model

The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro

Titanium and Titanium Alloys as Biomaterials

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