Biomechanical and Histological Evaluation of Osteochondral Transplantation in a Rabbit Model

Nam, Ellis K.; Makhsous, Mohsen; Koh, Jason L.; Bowen, Mark K.; Nuber, Gordon W.; Zhang, Liqun

doi:10.1177/0363546503259616

Cited by 59 publications

(87 citation statements)

References 31 publications

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“…Standard defects were created at a depth of 4 mm and a diameter of 4 mm with a standard disposable osteochondral autograft transport system (DePuy, Warsaw, IN), and the rest of the process was performed as suggested by Nam et al [20]. For all experiments, the right knee was the test and the left knee was the control.…”

Section: Methodsmentioning

confidence: 99%

The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty

Altan

Aydın

Erkoçak

et al. 2014

International Orthopaedics (SICOT)

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Purpose This study investigated the efficacy of platelet-rich plasma (PRP) on articular surfaces on which the mosaicplasty technique was performed. Our hypothesis was that PRP can accelerate the osseointegration process and enhance the quality of articular integrity after the mosaicplasty procedure. Methods Standard defects were created in the femoral groove of both patellofemoral joints of 12 New Zealand rabbits. PRP solution was placed inside the defect before fixation of the osteochondral autografts and injected inside the involved joint after capsular closure of the tested knees. The contralateral knees served as the control sides. The animals were euthanized three or six weeks after mosaicplasty, and both limbs were assessed according to Pineda's histological grading scale. Significance level was set at p≤0.05 a priori, and the Mann-Whitney U test was used for statistical analysis. Results Histologic findings at the interface between the transferred autograft and the original cartilage revealed better integration of the adjacent surfaces in the mosaicplasty with PRP group three weeks after the procedure; the difference was significant (p<0.05). However, no significant difference in the transition zone was observed between the groups six weeks after the experiment (p=0.59). Conclusions Our animal model showed that adjunctive use of PRP produced a better healing response and resulted in superior histological scores after three weeks compared with the mosaicplasty-only procedure. Interpretation of our results is important in terms of rapid return to previous activity levels. Thus, application of PRP can represent a valid therapeutic option for improving the efficacy of mosaicplasty by stimulating the local healing response.

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Section: Methodsmentioning

confidence: 99%

The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty

Altan

Aydın

Erkoçak

et al. 2014

International Orthopaedics (SICOT)

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“…In the transplanted osteochondral graft, stiffness might be temporarily decreased in the postoperative course [15,28]. We previously reported decreased stiffness at postoperative weeks 1, 3 and 8 compared to normal cartilage stiffness.…”

Section: Discussionmentioning

confidence: 99%

“…Histological analysis of transplanted osteochondral grafts indicates that, in an optimal autologous osteochondral transplantation, osteochondral grafts are incorporated into the defect, thereby, retaining the integrity of hyaline cartilage and cancellous bone, and maintaining the congruity of the articular surface in weight-bearing areas [5,13]. In contrast, changes in the mechanical properties of the transplanted osteochondral graft have been analysed in various autologous osteochondral transplantation models and evaluated at various periods after surgery [9,10,15,28]. We previously demonstrated that the structural properties of an osteochondral cylinder-graftrecipient construct immediately after surgery are not significantly different from those of normal cartilage and that the structural properties of an osteochondral cylindergraft-recipient reconstruction are significantly worse at postoperative weeks 1 through 8 than in normal cartilage [14].…”

Section: Introductionmentioning

confidence: 99%

The effect of fibroblast growth factor-2 on autologous osteochondral transplantation

Nakayama

Fujioka

Nagura

et al. 2007

International Orthopaedics (SICO

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In this study, we performed a mechanical analysis of the effect of fibroblast growth factor-2 (FGF-2) on autologous osteochondral transplantation in a rabbit model. A full-thickness cartilage defect (diameter: 5 mm; depth: 5 mm) made in the right femoral condyle was treated with osteochondral transplantation using an osteochondral plug (diameter: 6 mm; depth: 5 mm) taken from the left femoral condyle. The animals were divided into three groups: Group I, the defect was filled with 0

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“…23 In multiple studies including rabbit, ovine, and porcine models, chondrocytes and osteocytes of the osteochondral graft have been shown to survive transplantation. [24][25][26][27][28][29][30] Osteochondral grafting has also been used in the capitellum, talus, and femoral head, with graft viability proven with second-look arthroscopy, MRI, and biopsy. [31][32][33][34][35][36][37] The MRI of our patient at 21 months postoperative showed bone incorporation of the graft to the capitate and the presence of graft cartilage (►Fig.…”

Section: Discussionmentioning

confidence: 99%

Technique: Osteochondral Grafting of Capitate Chondrosis in PRC

Tang

Imbriglia

2013

Jnl Wrist Surg

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Proximal row carpectomy (PRC) has been shown in multiple studies to be an effective motion-preserving procedure for wrist arthritis. The operation consists of resection of the scaphoid, lunate, and triquetrum. 1 The proximal capitate and lunate fossa of the radius form the new wrist articulation, which makes the ideal patient free of degenerative changes at those articular surfaces. 2-8 Various authors, as well as the senior author, have maintained that when there is mild degeneration of these articular surfaces, PRC can still provide good to excellent results. [2][3][4][5][6]9 However, as wrist arthritis progresses, as in stage III scapholunate advanced collapse (SLAC) wrist or stage II/III scaphoid nonunion advanced collapse (SNAC) wrist, the proximal capitate becomes arthritic. With advanced degeneration, alternative surgical procedures include scaphoid excision, four-bone fusion, and wrist fusion. However, there Keywords ► osteochondral graft ► proximal row carpectomy AbstractBackground Proximal row carpectomy (PRC) is a useful treatment option for wrist arthritis, but the operation is contraindicated when there is arthritis of the capitate head. We describe a technique that involves resurfacing of a capitate that has focal chondrosis, using an osteochondral graft harvested from the resected carpal bones. Materials and Methods PRC patients who had a focal area of capitate chondrosis underwent osteochondral grafting of the capitate. Pre-and postoperative pain level, employment status, motion, grip strength, and Modified Mayo Wrist Scores (MMWS) were assessed. Postoperative Disability of the Arm, Shoulder, and Hand (DASH) scores were also calculated.

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Biomechanical and Histological Evaluation of Osteochondral Transplantation in a Rabbit Model

Abstract: Osteochondral transplantation may be a viable treatment option; however, long-term investigation on graft function is necessary.

Cited by 59 publications

References 31 publications

The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty

The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty

The effect of fibroblast growth factor-2 on autologous osteochondral transplantation

Technique: Osteochondral Grafting of Capitate Chondrosis in PRC

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