Biomechanical analysis of PDMS channels using different hyperelastic numerical constitutive models

Abstract

a b s t r a c tBrain aneurysms are pathological dilatations of cerebral arteries and are known as one of the most common and serious cerebrovascular events. However, patients with cerebral aneurysms do not exhibit evident symptoms until they rupture. The main objective of the present study is to perform numerical characterizations of the biomechanical behavior of aneurysms in order to analyze the blood vessel wall behavior during the formation of an aneurysm. By taking into account different geometric and physiological parameters, flow simulations of a well-known Newtonian fluid (glycerin) was performed using the commercial finite volume method package Ansys® -Fluent, and pressure along the channel was determined. These pressures were imported into the channel, in the Ansys®-Static Structural, in order to evaluate and analyze the displacement and strain fields in the channel wall, caused by the internal pressure induced by the fluid flow. All calculations were performed by using the most widely accepted hyperelastic constitutive models and it was found that any constitutive model can be applied to this kind of studies, allowing to visualize where pressure achieves its maximum value and consequently, the most favorable region where the rupture is more likely to occur.

Characterization of Shear Strain on PDMS: Numerical and Experimental Approaches

“…However, the results from in the Mooney-Rivlin and Polynomial hyperelastic models more adequately characterize the hyperelastic behaviour when compared with the experimental specimens. This statement is corroborated by other studies [42,43].…”

“…Nonlinear hyperelastic behaviours based on the constitutive models of Mooney-Rivlin, Yeoh, Polynomial and Gent were considered for the PDMS material. Many authors recommend these models for simulating PDMS materials [19,42]. The application of these models required determining several constants, which were identified from the experimental curves of the tensile tests.…”

Flexible PDMS microparticles to mimic RBCs in blood particulate analogue fluids

“…Recent microfluidic and micro-electro-mechanical systems (MEMS) have demonstrated that the high elasticity (flexibility) of polydimethylsiloxane (PDMS) offers unique advantages over more traditional rigid substrate materials such as glass and harder polymers [1,4] . Thus, PDMS has become the most widely used siliconbased organic polymer due to its unique mechanical and optical properties, and is generally considered inert, non-toxic and non-flammable, among other characteristics [3,[5][6][7] . Its applications range from contact lenses and medical devices to shampoos, caulking, lubricating oils and heat-resistant tiles [3,6] .…”

Manufacturing Process of a Brain Aneurysm Biomodel in PDMS Using Rapid Prototyping

“…Cerebral aneurysm or intracranial aneurysm is the abnormal dilatation of the blood vessel in a saccular form [1]. It may originate in congenital defects, weakening of the arterial wall with increasing age [2], atherosclerotic changes, trauma and infectious emboli. Other factors may be related to the onset of the aneurysm, such as hypertension, smoking, and excessive alcohol use.…”

“…The PDMS has an elastic behavior similar to arteries [8] and with numerous applications in biomedical [9][10][11][12]. The model was subsequently subjected to different experimental tests and numerical simulations [2,13].…”