Manufacturing Process of a Brain Aneurysm Biomodel in PDMS Using Rapid Prototyping

Souza, Andrews; Ribeiro, José Carlos Rabelo; Lima, Rui

doi:10.1007/978-3-030-32040-9_69

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…However, even performing these studies in animal models, neither human physiology nor human disease is fully recapitulated. In these types of experiments, the measurements are often inaccurate, and the experiments are expensive, have low reproducibility, and have associated ethical issues [3][4][5][6]. Therefore, engineered in vitro biomodels have gained widespread attention and have been developed to overcome those limitations.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

Carvalho

Rodrigues

Ribeiro³

et al. 2020

Micromachines

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Atherosclerosis is one of the most serious and common forms of cardiovascular disease and a major cause of death and disability worldwide. It is a multifactorial and complex disease that promoted several hemodynamic studies. Although in vivo studies more accurately represent the physiological conditions, in vitro experiments more reliably control several physiological variables and most adequately validate numerical flow studies. Here, a hemodynamic study in idealized stenotic and healthy coronary arteries is presented by applying both numerical and in vitro approaches through computational fluid dynamics simulations and a high-speed video microscopy technique, respectively. By means of stereolithography 3D printing technology, biomodels with three different resolutions were used to perform experimental flow studies. The results showed that the biomodel printed with a resolution of 50 μm was able to most accurately visualize flow due to its lowest roughness values (Ra = 1.8 μm). The flow experimental results showed a qualitatively good agreement with the blood flow numerical data, providing a clear observation of recirculation regions when the diameter reduction reached 60%.

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Section: Introductionmentioning

confidence: 99%

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

Carvalho

Rodrigues

Ribeiro³

et al. 2020

Micromachines

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“…VisiJet FTX was chosen to prevent additional surface treatment with sandpaper, acetone, glue or varnishes. This material has a good surface finish, strength and can also be used directly as a sacrificial core [19] .…”

Section: Rapid Prototyping Of the 3d Aneurysm Moldmentioning

confidence: 99%

“…Many researchers have developed in vitro techniques to enable experimental studies of blood flow in realistic configurations using direct rapid prototyping [19,20] or in the manufacture of negative molds [17,21] . However, it is difficult to choice the lost core (sacrificial) pattern material or to remove it, if one manufactures blood vessel biomodels uses negative molds [18] .…”

Section: Introductionmentioning

confidence: 99%

3D manufacturing of intracranial aneurysm biomodels for flow visualizations: Low cost fabrication processes

Souza

Pinho

et al. 2020

Mechanics Research Communications

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There is a continuous search for better and more complete in vitro models with mechanical properties closer to in vivo conditions. In this work a manufacturing process, based on a lost core casting technique, is herein reported to produce aneurysm biomodels to perform experimental hemodynamic studies. By using real artery images combined with a lost core casting technique, three materials were tested: paraffin, beeswax and glycerin-based soap. All in vitro biomodels were compared according to their transparency and final structure. Additionally, comparisons between experimental and numerical flow studies were also performed. The results have shown that the biomodels produced with beeswax and glycerine-based soap were the most suitable in vitro models to perform direct flow visualizations of particulate blood analogue fluids. The biomodels proposed in this works, have the potential to provide further insights into the complex blood flow phenomena happening at different kinds of pathologies and answer to important hemodynamics questions that otherwise cannot be tackled with the existing in vitro models.

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Heat Transfer and Fluid Flow Investigations in PDMS Microchannel Heat Sinks Fabricated by Means of a Low-Cost 3D Printer

Maia¹,

Rocha²,

Pontes³

et al. 2020

Advances in Microfluidic Technologies for Energy and Environmental Applications

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Manufacturing Process of a Brain Aneurysm Biomodel in PDMS Using Rapid Prototyping

Cited by 3 publications

References 19 publications

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

3D manufacturing of intracranial aneurysm biomodels for flow visualizations: Low cost fabrication processes

Heat Transfer and Fluid Flow Investigations in PDMS Microchannel Heat Sinks Fabricated by Means of a Low-Cost 3D Printer

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