Biomaterials, Tissue Engineering, and Regenerative Medicine: A Brief Outline

Bhaskar, Birru; Nagarjuna, Vasagiri

doi:10.1007/978-981-16-0002-9_1

Cited by 11 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An important advantage of microorganisms is that they can be genetically engineered to synthesize the desired compound for specific purposes. For microbial compounds to be used in TE, cost‐effectiveness, nontoxicity, and ease of processing are of paramount importance 209 . Microbial polymers found in recent years include cellulose, alginic acid, agar, carrageenan, chitin, dextran, gellan gum, pullulan, and hyaluronic acid 209 .…”

Section: Biochemical Factorsmentioning

confidence: 99%

“…For microbial compounds to be used in TE, cost‐effectiveness, nontoxicity, and ease of processing are of paramount importance 209 . Microbial polymers found in recent years include cellulose, alginic acid, agar, carrageenan, chitin, dextran, gellan gum, pullulan, and hyaluronic acid 209 . Microbial cellulose fibers are mainly derived from a gram‐negative bacterium called Acetobacter xylinum .…”

Section: Biochemical Factorsmentioning

confidence: 99%

“…Poly‐gamma‐glutamic acid and polyhydroxyalkanoates are other bacteria‐derived polymers of great interest in scaffold development and drug delivery because of their superior properties in homeostasis, cell adhesion, proliferation, and survival 209 . Microbial secondary metabolites, such as antibiotics, growth hormones, and antitumor agents, have great potential for medical applications.…”

Section: Biochemical Factorsmentioning

confidence: 99%

“…209 Microbial polymers found in recent years include cellulose, alginic acid, agar, carrageenan, chitin, dextran, gellan gum, pullulan, and hyaluronic acid. 209 Microbial cellulose fibers are mainly derived from a gram-negative bacterium called Acetobacter xylinum.…”

Section: Microbial-derived Compoundsmentioning

confidence: 99%

See 3 more Smart Citations

Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues

Bakhshandeh

Ranjbar

Abbasi

et al. 2022

Bioengineering & Transla Med

View full text Add to dashboard Cite

Tissue engineering (TE) is currently considered a cutting-edge discipline that offers the potential for developing treatments for health conditions that negatively affect the quality of life. This interdisciplinary field typically involves the combination of cells, scaffolds, and appropriate induction factors for the regeneration and repair of damaged tissue. Cell fate decisions, such as survival, proliferation, or differentiation, critically depend on various biochemical and biophysical factors provided by the extracellular environment during developmental, physiological, and pathological processes. Therefore, understanding the mechanisms of action of these factors is critical to accurately mimic the complex architecture of the extracellular environment of living tissues and improve the efficiency of TE approaches. In this review, we recapitulate the effects that biochemical and biophysical induction factors have on various aspects of cell fate. While the role of biochemical factors, such as growth factors, small molecules, extracellular matrix (ECM) components, and cytokines, has been extensively studied in the context of TE applications, it is only recently that we have begun to understand the effects of biophysical signals such as surface topography, mechanical, and electrical signals. These biophysical cues could provide a more robust set of stimuli to manipulate cell signaling pathways during the formation of the engineered tissue.Furthermore, the simultaneous application of different types of signals appears to elicit synergistic responses that are likely to improve functional outcomes, which could help translate results into successful clinical therapies in the future.

show abstract

Section: Biochemical Factorsmentioning

confidence: 99%

Section: Biochemical Factorsmentioning

confidence: 99%

Section: Biochemical Factorsmentioning

confidence: 99%

Section: Microbial-derived Compoundsmentioning

confidence: 99%

See 2 more Smart Citations

Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues

Bakhshandeh

Ranjbar

Abbasi

et al. 2022

Bioengineering & Transla Med

View full text Add to dashboard Cite

show abstract

“…Advancements in the synthesis of biomaterials have enabled tissue engineering (TE) and regenerative medicine to revolutionize modern medical treatments. 1 As one of the most effective biomedical treatments, TE provides innovative solutions for people with injuries and disabilities, 2 where a variety of multidisciplinary approaches are utilized for the evaluation, treatment, augmentation, healing, or replacement of biological tissues or organs. 3–5 Among various types of biomaterials, biopolymers with piezoelectric properties can sense mechanical distortion and generate electric cues as an efficient means of stimulating cell proliferation.…”

Section: Introductionmentioning

confidence: 99%