2015
DOI: 10.1159/000381700
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Biomaterials in the Reconstruction of the Oral and Maxillofacial Region

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Cited by 10 publications
(4 citation statements)
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“…The use of autogenous bone is associated with morbidities related to bone harvesting, prompting searches for alternatives to autologous bone grafts [28]. Allograft and xenograft bone substitutes have been used for craniofacial reconstructions, despite their limitations and frequent clinical failure [5]. Moreover, synthetic biomaterials, including bone onlays and facial fillers, are commonly used for facial augmentation, to restore bone contour and volume, and for rejuvenation.…”
Section: Discussionmentioning
confidence: 99%
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“…The use of autogenous bone is associated with morbidities related to bone harvesting, prompting searches for alternatives to autologous bone grafts [28]. Allograft and xenograft bone substitutes have been used for craniofacial reconstructions, despite their limitations and frequent clinical failure [5]. Moreover, synthetic biomaterials, including bone onlays and facial fillers, are commonly used for facial augmentation, to restore bone contour and volume, and for rejuvenation.…”
Section: Discussionmentioning
confidence: 99%
“…The use of autogenous bone, which is clinically considered the gold standard for repairing these defects, is the optimal option owing to its safety and efficiency, with reported success rates ranging between 84% and 93.3% [3][4][5]. Despite this, Rana et al noted that high resorption rates, bone necrosis, and infections are major drawbacks associated with free grafting for large defects [3].…”
Section: Introductionmentioning
confidence: 99%
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“…No entanto, esta modalidade de enxertia necessita de uma nova intervenção em um leito doador, podendo levar a uma maior morbidade para o paciente, um tempo cirúrgico mais alongado, aumento dos custos e possíveis sequelas decorrentes do ato cirúrgico (GAZDAG et al, 1995;MISCH, 1998;RAGHOEBAR et al, 2000;BAUER, 2000). Para reduzir os efeitos deletérios, de uma segunda abordagem cirúrgica, com o escopo da obtenção de um maior volume ósseo, alguns autores sugeriram a associação de xenoenxertos, aloenxertos aos biomateriais sintéticos (ALKUDMANI et al 2017, AYOUB et al 2015, BOW et al 2019. No entanto, esta associação de materiais pode levar a uma resposta imunológica inesperada (BIELENSTEIN et al 2022, SADOWSKA et al 2020, resultando em uma resposta inflamatória intensa, podendo levar a perda do material enxertado ou a infecções mais graves; isso é mais evidenciado em aloenxertos.…”
Section: Introductionunclassified