Biomaterials as therapeutic drug carriers for inflammatory bowel disease treatment

Wang, Chi‐Pin James; Byun, Min Ji; Kim, Se-Na; Park, Wooram; Park, Hee Ho; Kim, Tae-Hyung; Lee, Jung Seung; Park, Chun Gwon

doi:10.1016/j.jconrel.2022.02.028

Cited by 41 publications

(22 citation statements)

References 159 publications

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“…Nanoparticles (NPs) are extraordinarily potential vehicles as colon-targeted DDSs in IBD therapy due to their small size, large surface area, shape modulation and high surface functionality. 63–66 Meanwhile, NPs possess with preferable stability to protect encapsulated agents against harsh biological environments in the GI tract, such as low pH and enzyme degradation. 67,68 Therefore, several researchers have been devoted to engineering suitable NPs as colon-targeted DDSs for IBD treatment in the past years.…”

Section: Np Systemsmentioning

confidence: 99%

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Yang

et al. 2022

J. Mater. Chem. B

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Section: Np Systemsmentioning

confidence: 99%

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Yang

et al. 2022

J. Mater. Chem. B

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“…The accumulation of ROS is responsible for the lipid peroxidation of the hydroxyl radical, hydrogen and superoxide anion. ROS are associated with alterations and damage to cellular constituents (membrane lipids, nucleic acids and proteins), which signal several complications for human health (inflammation, proliferation and differentiation of stem cells, chronic wounds, bone defects, Parkinson’s and Alzheimer’s diseases, among others) and negative implications for food (reduction of shelf life, change in taste, aroma and odor) [ 26 , 27 ]. In this context, natural antioxidant biomaterials become promising to inhibit or delay molecular oxidative stress through the release of compounds with antioxidant activity, as shown in Figure 3 [ 26 ].…”

Section: Biomaterialsmentioning

confidence: 99%

“…The use of marine organisms to develop antioxidant biomaterials has also been well explored to remove ROS responsible for molecular oxidation. For example, in the study by Wang et al [ 27 ], hydrogels were formed based on recombinant thrombospondin antioxidant protein (rich in cysteine residues), which is extracted from adhesive components of sea anemones. These hydrogels were able to prevent cellular oxidative damage, decrease lipid oxidation in the skin of mice, and stimulate endogenous antioxidant systems.…”

Section: Biomaterialsmentioning

confidence: 99%

“…Carrageenan films (sulfated polysaccharides from red seaweed), ulvan hydrogels (sulfated polysaccharides from green seaweed), and alginate hydrogels (obtained from brown seaweed) also show numerous bioactive antioxidant properties and promising viscoelastic properties for use in medical applications, food or even as anti-polluting agents [ 27 , 28 , 29 ]. Like alginate, chitosan polymers (polysaccharides extracted from the exoskeletons of crustaceans) are the matrices most used as biomaterials associated with antioxidants.…”

Section: Biomaterialsmentioning

confidence: 99%

“…Some biomaterials require long-lasting duration in tissues or permanent integration into them; thus, the controlled release of antioxidants can be achieved more or less slowly in balance with the scaffold’s physical features and biodegradation [ 57 ]. Many loaded antioxidant components are released too quickly, are released in incomplete form, or are unstable during the release process [ 27 ].…”

Section: Biological Properties and Release Of Antioxidants From Bioma...mentioning

confidence: 99%

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The Importance of Antioxidant Biomaterials in Human Health and Technological Innovation: A Review

et al. 2022

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Biomaterials come from natural sources such as animals, plants, fungi, algae, and bacteria, composed mainly of protein, lipid, and carbohydrate molecules. The great diversity of biomaterials makes these compounds promising for developing new products for technological applications. In this sense, antioxidant biomaterials have been developed to exert biological and active functions in the human body and industrial formulations. Furthermore, antioxidant biomaterials come from natural sources, whose components can inhibit reactive oxygen species (ROS). Thus, these materials incorporated with antioxidants, mainly from plant sources, have important effects, such as anti-inflammatory, wound healing, antitumor, and anti-aging, in addition to increasing the shelf-life of products. Aiming at the importance of antioxidant biomaterials in different technological segments as biodegradable, economic, and promising sources, this review presents the main available biomaterials, antioxidant sources, and assigned biological activities. In addition, potential applications in the biomedical and industrial fields are described with a focus on innovative publications found in the literature in the last five years.

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Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease

Zhang

Wang

Sun

et al. 2023

Adv Healthcare Materials

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Inflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with a variety of painful clinical manifestations and an increased risk of cancerization or death, has become an emerging challenge to global healthcare due to its rapidly increasing incidence. At present, there is no efficient cure against IBD because of the elusive etiology and pathogenesis of IBD. Therefore, the development of alternative therapeutic strategies with positive clinical efficacy and reduced side effects is urgently needed. In recent years, the great prosperity of nanomedicine promoted by a variety of advanced nanomaterials is redefining more attractive and promising therapeutic strategies for IBD owing to their advantages in the physiological stability, bioavailability, and targeting of inflammatory sites. In this review, firstly the basic characteristics of healthy and inflammatory intestinal microenvironments are presented. Then, different administration routes and targeting strategies of nanotherapeutics for IBD treatment are reviewed. Subsequently, a specific focus is placed on the introduction of nanotherapeutic treatments based on different IBD pathogenesis. Finally, some future challenges and perspectives of the currently developed nanomedicines for IBD treatment are provided. It is believed that the above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry and pharmaceutics.

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Biomaterials as therapeutic drug carriers for inflammatory bowel disease treatment

Cited by 41 publications

References 159 publications

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

The Importance of Antioxidant Biomaterials in Human Health and Technological Innovation: A Review

Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease

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