Biomaterials and tissue engineering for scar management in wound care

Rahimnejad, Maedeh; Derakhshanfar, Soroosh; Zhong, Wen

doi:10.1186/s41038-017-0069-9

Cited by 53 publications

(49 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An optimal DS should be impermeable to exogenous bacteria, resistant to linear and shear stresses, and have minimal storage requirements and a long shelf life. Importantly, it should incorporate into the patient with minimal scarring and also facilitate angiogenesis . Nevelia showed increased angiogenesis, as shown by CD31 and α‐SMA immunohistochemistry, vs Integra DS (Figure ).…”

Section: Discussionmentioning

confidence: 99%

Long‐term follow‐up comparison of two different bi‐layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings

Angelis

Orlandi

D'Autilio

et al. 2018

International Wound Journal

View full text Add to dashboard Cite

Double layer dermal substitute (DS) consist of a 3‐dimensional collagen structures and a superficial silicon layer that are positioned within the defect provide to promote tissue regeneration in skin wounds. DS often have unique physical characteristics due to differences in manufacturing techniques. The aim of this study is the clinical and histological comparison of Nevelia and Integra double layer DSs in patients with post‐traumatic injury wounds. Thirty patients with post‐traumatic wounds localised on the inferior limbs were randomised in 2 groups Nevelia or Integra, followed by autologous dermal epidermal graft (DEG). Clinical results were evaluated through the healing time; Manchester Scar Scale (MSS) and Visual Analog Scale (VAS) at 1, 2, and 3 weeks and after 1 and 3 years. Histological and immunohistochemical evaluation were performed at 0, 2, and 3 weeks. The difference in healing time between groups (P = .467, log‐rank test), pain and self‐estimation was not statistically significant after 35, 42, and 49 days and at 1‐year follow up. Histological data showed evident healing of wound after 2 weeks compared with preoperative with both DSs. At 3 weeks reepithelialisation and dermal regeneration were evident with both substitutes; however Nevelia showed early regenerative properties in terms of epidermal proliferation and dermal renewal compared with Integra. Nevelia showed also a more evident angiogenesis vs Integra evaluated as α‐SMA immunohistochemistry. Differences in the MSS score were statistically significant at 3 years follow up in favour of Nevelia group (P = .001). At long‐term follow up, Nevelia showed a better clinical outcome measured as MSS score vs Integra measured as MSS. Histological and immunohistochemistry data showed that Nevelia allows faster neoangiogenesis and tissue regeneration with neoformed tissue architecture closer to the physiology of the skin.

show abstract

Section: Discussionmentioning

confidence: 99%

Long‐term follow‐up comparison of two different bi‐layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings

Angelis

Orlandi

D'Autilio

et al. 2018

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…The use of phototherapy has been shown to significantly reduce the number of immune cells within a rat burn wound, increasing angiogenesis and collagen deposition [87] and may herald a new area of research for the development of devices to treat burn wounds. Novel biomaterials are also being investigated in the treatment of burn injuries, not only to provide a provisional matrix or augment skin grafting, but are also being assessed for their ability to modulate the immune response [88]. Fibrin-based hydrogels delivered into pig burn wounds prevented contracture but also reduced immune cells within the hydrogel as well as reducing neutrophil and macrophage numbers within the in the surrounding granulation tissue on day 7 post burn [89].…”

Section: Enhancement Of the Resolution Of The Inflammatory Responsementioning

confidence: 99%

The Role of the Inflammatory Response in Burn Injury

Strudwick¹,

Cowin²

2018

Hot Topics in Burn Injuries

View full text Add to dashboard Cite

Burns are characterised by significant local swelling and redness around the site of injury, indicative of acute inflammation. Whilst the inflammatory response is fundamental to the healing process, triggering a cascade of cytokines and growth factors to protect against the risk of infection, it is clear that prolonged inflammation can be detrimental and lead to scarring and fibrosis. Severe burns may display chronic, persistent inflammation long after the initial burn injury and may even result in multiple organ failure (MOF) due to systemic inflammatory response syndrome (SIRS). Excessive inflammation in the early stages of healing has been identified as a causative factor in the formation of scars which can be disfiguring, functionally restrictive and may require revisionary surgeries. Therefore, it is imperative that inflammation is effectively managed following burn injuries in order to optimise the benefits it provides whilst actively preventing the complications of inflammation including SIRS, multiple organ failure (MOF) and the development of scarring and fibrosis. Reviewing the current knowledge about the role of the inflammatory response in burns and the treatments available for the management of inflammation during wound healing, highlights the importance of continued research into understanding and developing new approaches to regulate inflammatory responses post-burn injuries.

show abstract

“…Due to high water content, hydrogels are considered biodegradable soft materials being able to mimic soft tissue. Due to their biodegradability and biocompatibility, hydrogels have found important applications in wound dressing [21], biomedical implants [22], cell studies, etc. To find out the suitability of any specific hydrogel for these types of applications, it is required to study the amount of water they can absorb over time.…”

Section: Characterization Of Chitosan-chemical Structures (Ftir and Nmentioning

confidence: 99%

Characterization and Application of Carboxymethyl Chitosan-Based Bioink in Cartilage Tissue Engineering

Derakhshanfar

Zhong

et al. 2020

Journal of Nanomaterials

Self Cite

View full text Add to dashboard Cite

Chitosan is a promising natural biomaterial for biological application; however, the weak mechanical performance of pristine chitosan limits its further utilization in hard tissue (such as cartilage) engineering. In this study, a chitosan-based 3D printing bioink with suitable mechanical properties was developed as 3D bioprinting ink for chondrocyte support. Chitosan was first modified by ethylenediaminetetraacetic acid (EDTA) to provide more carboxyl groups followed by physical crosslinking with calcium to increase the hydrogel strength. Dynamic mechanical analysis was carried out to evaluate viscoelastic properties with the addition of modified chitosan. A bioink with a combination of modified and pristine chitosan was formulated for scaffold fabrication via 3D bioprinting technique. Furthermore, cell viability, cell proliferation, and expression of chondrogenic markers were evaluated in vitro in chondrocytes loaded on the bioink. The novel bioink exhibited a favorable mechanical property and promoted cell attachment and chondrogenic gene expression in chondrocytes. Based on these results, we can conclude that the presented bioink could qualify for use in 3D bioprinting in cartilage tissue engineering.

show abstract

Biomaterials and tissue engineering for scar management in wound care

Cited by 53 publications

References 67 publications

Long‐term follow‐up comparison of two different bi‐layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings

Long‐term follow‐up comparison of two different bi‐layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings

The Role of the Inflammatory Response in Burn Injury

Characterization and Application of Carboxymethyl Chitosan-Based Bioink in Cartilage Tissue Engineering

Contact Info

Product

Resources

About