Biomaterials and Sol–Gel Process: A Methodology for the Preparation of Functional Materials

Nassar, Eduardo J.; Ciuffi, Kátia J.; Calefi, Paulo S.; Rocha, Lucas A.; Faria, Emerson H. de; Silva, Márcio Luís Andrade e; Luz, Priscilla Paiva; Bandeira, Lucimara C.; Cestari, Alexandre; Fernandes, Cristianine N.

doi:10.5772/23202

Cited by 5 publications

(3 citation statements)

References 75 publications

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“…Sol-gel is a suitable process for creating biocompatible materials [10][11][12]. Through the hydrolysis and polycondensation processes of organometallic compounds inside a hydroalcoholic solution, this procedure is often used to produce ceramic oxides at low temperatures [13].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Organic–Inorganic Materials Prepared by Sol–Gel and Sol–Gel-Coating Method for Biomedical Use: Study and Synthetic Review of Synthesis and Properties

Barrino

2024

Coatings

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The need to improve the expectancy and quality of life of subjects affected by disabling pathologies that require the replacement or regeneration of tissues or parts of the body has fueled the development of innovative, better-performing materials that are capable of integrating into and being tolerated by body tissues. Materials with these characteristics, i.e., bio-functionality, bio-safety, and biocompatibility, are defined as biomaterials. One of the many methods for producing such materials is the sol–gel technique. This process is mainly used for the preparation of ceramic oxides at low temperatures, through hydrolysis and polycondensation reactions of organometallic compounds within a hydroalcoholic solution. This study is based on a specific type of biomaterial: organic–inorganic hybrids. The aim of this study is to provide an overview of the advantages and disadvantages of the sol–gel technique, as well as describe the preparation and chemical and biological characterization, uses, and future prospects of these biomaterials. In particular, the use of plant drugs as organic components of the hybrid material is the innovation of this manuscript. The biological properties of plant extracts are numerous, and for this reason, they deserve great attention from the scientific community.

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Section: Introductionmentioning

confidence: 99%

Hybrid Organic–Inorganic Materials Prepared by Sol–Gel and Sol–Gel-Coating Method for Biomedical Use: Study and Synthetic Review of Synthesis and Properties

Barrino

2024

Coatings

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“…Successful use of a biomaterial is possible after entrapment in biocompatible matrices, in which intactness and functional properties are fully preserved [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. One of the widely used approaches is sol–gel technology [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. During the synthesis, biopolymers are mineralized and hybrid structures with a nanosized inorganic component are formed [ 10 , 18 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…Sol–gel technology has a number of undoubted advantages, which made it popular for the silicification of biomaterial [ 9 , 20 , 22 , 26 , 30 , 31 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. These include control over synthesis conditions—pH, salt composition, additives of various substances, and temperature.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Sol–Gel Chemistry to Tailor Structure, Properties, and Functionality of Bionanocomposites by Biopolymers and Cells

Shchipunov

2023

Materials

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Biosilica, synthesized annually only by diatoms, is almost 1000 times more abundant than industrial silica. Biosilicification occurs at a high rate, although the concentration of silicic acid in natural waters is ~100 μM. It occurs in neutral aqueous solutions, at ambient temperature, and under the control of proteins that determine the formation of hierarchically organized structures. Using diatoms as an example, the fundamental differences between biosilicification and traditional sol–gel technology, which is performed with the addition of acid/alkali, organic solvents and heating, have been identified. The conditions are harsh for the biomaterial, as they cause protein denaturation and cell death. Numerous attempts are being made to bring sol–gel technology closer to biomineralization processes. Biomimetic synthesis must be conducted at physiological pH, room temperature, and without the addition of organic solvents. To date, significant progress has been made in approaching these requirements. The review presents a critical analysis of the approaches proposed to date for the silicification of biomacromolecules and cells, the formation of bionanocomposites with controlled structure, porosity, and functionality determined by the biomaterial. They demonstrated the broad capabilities and prospects of biomimetic methods for creating optical and photonic materials, adsorbents, catalysts and biocatalysts, sensors and biosensors, and biomaterials for biomedicine.

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MSCs and Innovative Injectable Biomaterials in Dentistry

Fasolino

Raucci

Ambrosio

2017

Stem Cell Biology and Regenerative Medicine

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Biomaterials and Sol–Gel Process: A Methodology for the Preparation of Functional Materials

Cited by 5 publications

References 75 publications

Hybrid Organic–Inorganic Materials Prepared by Sol–Gel and Sol–Gel-Coating Method for Biomedical Use: Study and Synthetic Review of Synthesis and Properties

Hybrid Organic–Inorganic Materials Prepared by Sol–Gel and Sol–Gel-Coating Method for Biomedical Use: Study and Synthetic Review of Synthesis and Properties

Biomimetic Sol–Gel Chemistry to Tailor Structure, Properties, and Functionality of Bionanocomposites by Biopolymers and Cells

MSCs and Innovative Injectable Biomaterials in Dentistry

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