Biomaterials and Biomedical Devices

Hanker, Jacob S.; Giammara, B.

doi:10.1126/science.3055300

Cited by 134 publications

(59 citation statements)

References 53 publications

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“…Although most implant-related infections are caused by gram-positive bacteria, infections caused by gram-negative bacteria are potentially more These are complicated by the presence of a bacterial biofilm of microbes that are able to attach firmly to solid surfaces, such as catheters and prosthetic devices, and produce a glycocalyx matrix inside which microcolonies coalesce and thrive. ', 5- 7 The establishment of biofilm by invading pathogens provides survival advantages and, consequently, host This may be attributed to the occurrence of bacterial biofilm on peritoneal catheters as a result of sub-therapeutic concentrations of antibiotic in the peritoneum towards the end of the dwell time. This problem could be overcome by the administration of a sustained release antibiotic formulation such as a micro-particle that delivers the antibiotic continuously during the dwell time of the peritoneal dialysate.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of sustained release ciprofloxacin microspheres against device-associated Pseudomonas aeruginosa biofilm infection in a rabbit peritoneal model

Owusu-Ababio

Rogers²,

Morck³

et al. 1995

Journal of Medical Microbiology

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Summary. The relative effectiveness of a poly( L-lactic acid) ciprofloxacin hydrochloride (CIP) microsphere formulation (250-425 pm) against peritoneal implanted biofilm of Pseudomonas aeruginosa was investigated in a rabbit model. Correlations between in-vivo CIP pharmacokinetics in peritoneal dialysate and serum after intraperitoneal administration, in-vivo cell counts and rabbit survival rate were obtained. Dialysate and serum concentrations after 12 h (C,,,) were greater than those obtained with free drug whereas maximum serum concentrations (C,,,) were lower and the time to reach Cmax(tmax) was longer. A silastic implant device pre-colonised with P . aeruginosa for 2 days was implanted in the rabbit peritoneum, and dialysate with or without drug or microspheres was administered via a catheter. Rabbits receiving no antibiotic and those receiving free drug (10 mg in dialysate) died of peritonitis and septicaemia, whereas all rabbits given CIP microspheres recovered completely from infection. The viable count of P . aeruginosa was markedly reduced or eliminated from the catheter, the device and the peritoneal wall in CIP microsphere-treated rabbits but not in rabbits treated with free drug, as determined from histological and scanning electronmicroscopic evidence. These results demonstrate that sustained release of antibiotics at biofilm eradication concentrations (BEC) is required to treat biofilm infections associated with

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Section: Introductionmentioning

confidence: 99%

Efficacy of sustained release ciprofloxacin microspheres against device-associated Pseudomonas aeruginosa biofilm infection in a rabbit peritoneal model

Owusu-Ababio

Rogers²,

Morck³

et al. 1995

Journal of Medical Microbiology

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“…biodegradable implant | bone formation | clinical application T he century-old concept of the fixation device that holds the fractured bones in place to allow repair through the natural bone remodeling process is still being practiced today without alteration (1)(2)(3)(4)(5). The recent rapid growth of the elderly demographic of physically active adults has tremendously intensified the occurrence of bone trauma cases, highlighting once again the major drawbacks of current surgical approaches and osteosynthesis systems, such as inevitable secondary surgery to remove the inert fixation devices after complete bone healing and inflammatory response due to the release of metal ions.…”

mentioning

confidence: 99%

Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy

Lee

Han

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

365

236

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There has been a tremendous amount of research in the past decade to optimize the mechanical properties and degradation behavior of the biodegradable Mg alloy for orthopedic implant. Despite the feasibility of degrading implant, the lack of fundamental understanding about biocompatibility and underlying bone formation mechanism is currently limiting the use in clinical applications. Herein, we report the result of long-term clinical study and systematic investigation of bone formation mechanism of the biodegradable Mg-5wt%Ca-1wt%Zn alloy implant through simultaneous observation of changes in element composition and crystallinity within degrading interface at hierarchical levels. Controlled degradation of Mg-5wt%Ca-1wt%Zn alloy results in the formation of biomimicking calcification matrix at the degrading interface to initiate the bone formation process. This process facilitates early bone healing and allows the complete replacement of biodegradable Mg implant by the new bone within 1 y of implantation, as demonstrated in 53 cases of successful long-term clinical study.biodegradable implant | bone formation | clinical application T he century-old concept of the fixation device that holds the fractured bones in place to allow repair through the natural bone remodeling process is still being practiced today without alteration (1-5). The recent rapid growth of the elderly demographic of physically active adults has tremendously intensified the occurrence of bone trauma cases, highlighting once again the major drawbacks of current surgical approaches and osteosynthesis systems, such as inevitable secondary surgery to remove the inert fixation devices after complete bone healing and inflammatory response due to the release of metal ions. In the past decade, countless studies have been performed to control and optimize the mechanical and corrosion properties of magnesium-based alloys (6-9), which, thanks to their degradation in the physiological environment, could overcome the limitations of inert implant materials and shift the paradigm of conventional bone fixation devices toward new horizons. Driven by these new possibilities, important findings regarding, among others, the degradation mechanism of Mg-based alloys (10, 11), the formation of corrosion protective layers by degradation products (12, 13), and the osteogenetic properties of Mg ions (14, 15) have been reported in the literature. However, such findings are based on the observation of degradation products and of bone healing at the macroscale level. Due to lack of fundamental understanding on biocompatibility and underlying bone formation mechanism of the degradation product, there is so far only one known case of statistically insignificant clinical study result (16) with a short-term follow-up. In our previous study, we reported successful development and long-term in vivo study of uniformly slowly degrading Mg-5wt%Ca-1wt%Zn alloy system (SI Appendix, Figs. S1 and S2) featuring adequate mechanical strength [ultimate tensile strength (UTS) ∼250 MPa] (17) a...

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“…Для достижения этой цели потребуется глубокое понимание нормаль-ных физиологических процессов развития тканей и механизмов, лежащих в основе взаимодействия между МСК и биоматериалами во время ткане-образования, поскольку многие важные детали остаются неясными [17]. Биоматериалы играют решающую роль при создании тканеинженер-ных конструкций [25]. Материал должен иметь возможность сохранять свою структуру и целост-ность в течение предсказуемых периодов времени для обеспечения нового формирования и созре-вания тканей даже в условиях нагрузки [24,50].…”

Section: заключениеunclassified