Role of Mesenchymal Multipotent Stromal Cells in Remodeling of Bone Defects

Киселевский, М. В.; Anisimova, N. Yu.; Должикова, Ю. И.; Власенко, Р. Я.; Сенатов, Ф.С.; Караулов, А. В.

doi:10.15789/1563-0625-2018-4-515-522

Cited by 1 publication

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References 53 publications

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“…Normally, bone tissue repair is impossible both without the synthetic function of osteoblasts and without the resorptive action of osteoclasts; therefore, the regenerative potential of bone tissue decreases against the background of the action of antiresorptive drugs [18]. For the jaw bones, this is especially critical, since they are covered with a thin mucous membrane, actively colonized by microflora, communicate with the external environment through periodontal fissures and experience constant stress [7].…”

Section: Pathogenesis Of Medicinal Osteonecrosis Of the Jawsmentioning

confidence: 99%

Prevention of Drug Osteonekrosis of Jaws: Current State of the Problem

EM¹

2021

MRD

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The problem of prevention of medicinal osteonecrosis of the jaws is one of the lively discussions of the last decade in dentistry. Osteomodifying drugs (bisphosphonates, denosumab) most often cause medicinal osteonecrosis of the jaws. They are used to suppress resorption in osteoporosis, metastatic lesions of the bones of the skeleton, aseptic necrosis of the femoral and humerus heads, various genetic diseases accompanied by osteogenesis imperfecta and osteopenic syndrome. Due to the high prevalence of osteoporosis and malignant neoplasms in the population, the prescription of osteomodifying drugs has become a routine practice. Medicinal osteonecrosis of the jaws is an iatrogenic disease that is difficult to treat and leads to serious consequences in the form of a pathological fracture of the jaw, a chronic purulent-inflammatory process, and extensive defects in the jaw bone tissue. It is known that the most common drug osteonecrosis of the jaws occurs after tooth extraction surgery in patients taking osteo modifying drugs. To date, no method has been developed with proven efficacy that can completely prevent the disease, therefore, much attention is paid to measures that reduce the risks of complications. Providing surgical dental care to this category of patients is a difficult task. All of the above determined the task of researching and generalizing the basic principles of prevention of drug-induced osteonecrosis of the jaws in patients with a history of osteomodifying therapy, which are presented in this review.

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Section: Pathogenesis Of Medicinal Osteonecrosis Of the Jawsmentioning

confidence: 99%

Prevention of Drug Osteonekrosis of Jaws: Current State of the Problem

EM¹

2021

MRD

View full text Add to dashboard Cite

show abstract

Role of Mesenchymal Multipotent Stromal Cells in Remodeling of Bone Defects

Cited by 1 publication

References 53 publications

Prevention of Drug Osteonekrosis of Jaws: Current State of the Problem

Prevention of Drug Osteonekrosis of Jaws: Current State of the Problem

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