Biomarkers of Potential Harm Among Adult Smokers and Nonsmokers in the Total Exposure Study

Frost-Pineda, Kimberly; Liang, Qiwei; Liu, Jianmin; Rimmer, Lonnie; Jin, Yan; Feng, Shixia; Kapur, Sunil; Mendes, Paul; Roethig, Hans J.; Sarkar, Mohamadi

doi:10.1093/ntr/ntq235

Cited by 65 publications

(83 citation statements)

References 36 publications

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“…Several studies have shown the inverse association between smoking and bilirubin levels [6,7,17,18]. In our studies, there were more never smokers in the high-TBIL and high-IBIL groups than the low-TBIL and low-IBIL groups, respectively.…”

Section: Discussionsupporting

confidence: 54%

Elevated serum bilirubin levels are associated with improved survival in patients with curatively resected non-small-cell lung cancer

Cai

et al. 2015

Cancer Epidemiology

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Section: Discussionsupporting

confidence: 54%

Elevated serum bilirubin levels are associated with improved survival in patients with curatively resected non-small-cell lung cancer

Cai

et al. 2015

Cancer Epidemiology

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“…Biomarkers of tobacco exposure or potential harm have previously been analyzed for cigarette smokers (16)(17)(18)(19)(20)(21)(22), but less information is available about biomarkers associated with cigar consumption. It has been shown that cigar smoke contains significantly higher concentrations of toxic and carcinogenic constituents such as tobaccospecific N-nitrosamines (TSNA), carbon monoxide, and benzene than does cigarette smoke (6).…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Exposure among U.S. Cigar Smokers: An Analysis of 1999–2012 National Health and Nutrition Examination Survey (NHANES) Data

Chen

Kettermann

Rostron

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Cigar consumption is increasing in the United States, but little information is available about exposure to toxic constituents from cigar smoking.Methods: We conducted a cross-sectional analysis of biomarkers of tobacco exposure among 25,522 participants from the National Health and Nutrition Examination Survey (NHANES, 1999(NHANES, -2012. The biomarkers analyzed were serum cotinine, urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), blood lead, blood cadmium, and urinary arsenic. We calculated geometric mean concentrations for each biomarker by tobacco use category and geometric mean ratios controlling for demographic factors.Results: Cigar smokers had higher cotinine, NNAL, and lead concentrations than nontobacco users. The geometric mean concentration [95% confidence interval (CI)] of cotinine for primary cigar smokers (i.e., current cigar/never cigarette smokers) was 6.2 (4.2-9.2) ng/mL versus 0.045 (0.043-0.048) ng/mL for nontobacco users, and the NNAL concentration was 19.1 (10.6-34.3) pg/mg creatinine for primary cigar smokers versus 1.01 (0.95-1.07) pg/mg creatinine for nontobacco users. Secondary cigar smokers (i.e., current cigar/former cigarette smokers) and dual cigar/cigarette smokers had higher cadmium concentrations than nontobacco users. Cigar smoking was associated with significantly higher concentrations of cotinine, NNAL, cadmium, and lead, after adjusting for demographic factors. Secondary cigar smokers had significantly higher cotinine and NNAL concentrations than primary cigar smokers. The NNAL concentrations in daily cigar smokers were comparable with those in daily cigarette smokers.Conclusions: Cigar smokers have higher concentrations of several toxic and carcinogenic substances than nontobacco users.Impact: Our results are consistent with epidemiologic evidence demonstrating cigar smoking as a cause of disease and premature death. Cancer Epidemiol Biomarkers Prev; 23(12); 2906-15. Ó2014 AACR.

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“…ACHA survey data collected biannually in the Fall of 2008 through the Spring of 2012 show that 28.5-36.2% of male students reported ever using hookah tobacco compared to 22.6-30.1% of female students (7,(40)(41)(42)(43)(44)(45)(46). Although males have a higher prevalence of hookah tobacco smoking than females, females experience a faster decline in pulmonary function (26,30,47), a greater likelihood for nicotine dependence, and a higher prevalence of respiratory symptoms and lung disease (48).…”

Section: Demographic Characteristicsmentioning

confidence: 99%

“…Similar to other tobacco products, hookah tobacco confers an increased risk for impairment of pulmonary function (26,27), lung diseases (28,29), periodontal disease (28,30), and cardiovascular disease (8). However, hookah tobacco produces higher levels of toxicants than cigarettes (31).…”

Section: Introductionmentioning

confidence: 99%

Review of hookah tobacco smoking among college students: policy implications and research recommendations

Gathuru¹,

Tarter²,

Klein‐Fedyshin

2015

The American Journal of Drug and Alcohol Abuse

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Background: About 30% of college students have smoked hookah tobacco. Although most students perceive this product to be innocuous and non-addictive, hookah tobacco increases the risk for disease and nicotine dependence. Currently, the US Food and Drug Administration (FDA) does not regulate the manufacture, distribution, or sale of hookah tobacco. Objective: Empirical literature pertaining to hookah tobacco smoking is reviewed with a focus on the implications for regulatory policy. Methods: PubMed, PsycINFO, and Scopus databases were searched to locate articles published in English. The literature search combined

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Biomarkers of Potential Harm Among Adult Smokers and Nonsmokers in the Total Exposure Study

Abstract: These results contribute to the understanding of the relationship between tobacco smoking and potential biological effects.

Cited by 65 publications

References 36 publications

Elevated serum bilirubin levels are associated with improved survival in patients with curatively resected non-small-cell lung cancer

Elevated serum bilirubin levels are associated with improved survival in patients with curatively resected non-small-cell lung cancer

Biomarkers of Exposure among U.S. Cigar Smokers: An Analysis of 1999–2012 National Health and Nutrition Examination Survey (NHANES) Data

Review of hookah tobacco smoking among college students: policy implications and research recommendations

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