Biomarkers of Air-Blood Barrier Damage In COVID-19

Khadzhieva, Maryam B.; Gracheva, A. S.; Ершов, А. В.; Chursinova, Yulia V.; Stepanov, Vadim; Avdeikina, Lyudmila S; Гребенчиков, О. А.; Babkina, Anastasiya S.; Шабанов, А. К.; Tutelyan, A.V.; Петриков, С. С.; Kuzovlev, Аrtem

doi:10.15360/1813-9779-2021-3-2-0

Cited by 6 publications

(1 citation statement)

References 53 publications

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“…The study sample, as well as the inclusion and exclusion criteria, have been described in detail previously [6]. The total sample (n=109) consisted of patients discharged from ICU in stable condition (n=90) and patients with fatal outcome (n=19).…”

Section: Methodsmentioning

confidence: 99%

Predictors of Mortality in Hospitalized Covid-19 Patients

Khadzhieva¹,

Gracheva²,

Yadgarov³

et al. 2022

ArveMED

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When treating patients with COVID-19, prognostic and diagnostic tests to assess the risk of severe disease and adverse outcome are particularly important. The analysis of demographic, clinical, laboratory and instrumental data obtained on ICU admission was performed on a sample of 109 patients to determine potential predictors of lethal outcome. The factors increasing the risk of adverse outcome included age ≥57 years (AUC = 0.777, P < 0.001), hypertension (RR = 3.073, P = 0.033), ARDS (RR = 17.455, P < 0.001), advanced chest CT severity score (HR = 1.569, P = 0.039), severe and critical COVID-19 (RR = 6.964, P = 0.016), neutrophilia (AUC = 0.729, P = 0.005), lymphopenia (AUC = 0.705, P = 0.023), thrombocytopenia (AUC = 0.713, P = 0.018), reduced MCHC (AUC = 0.700, P = 0.026), elevated RDW (AUC = 0.718, P = 0.007), LDH (AUC = 0.891, P = 0.005) and D-dimer (AUC = 0.806, P = 0.029).

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Section: Methodsmentioning

confidence: 99%

Predictors of Mortality in Hospitalized Covid-19 Patients

Khadzhieva¹,

Gracheva²,

Yadgarov³

et al. 2022

ArveMED

View full text Add to dashboard Cite

show abstract

Clinical Utility of Circulating Pneumoproteins as Diagnostic and Prognostic Biomarkers in COVID-19: A Systematic Review and Meta-analysis

Zhu

Chen

et al. 2022

Infect Dis Ther

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Prognostic Value of Cystatin C as a Predictor of Adverse Outcome in Severe Pneumonia Associated with COVID-19

Korabelnikov¹,

Magomedaliev²,

Khoroshilov

2023

Obŝaâ reanimatologiâ

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Objective. To assess the cystatin C (CysC) prognostic value for probability of death in patients with severe and extremely severe pneumonia associated with COVID-19.Material and methods. A single-center prospective study included 72 patients with severe and extremely severe pneumonia associated with COVID-19 undergoing treatment in the ICU of multifunctional medical center from September 2020 to October 2021. Recovered survivors (N=55) were analyzed as a Group 1, nonsurvivors (N=17) were considered as a Group 2.Results. The serum (s-CysC) and urine (u-CysC) CysC concentrations were significantly lower in Group 1 patients vs Group 2, averaging 1.31 mg/l vs 1.695 mg/l (P=0.013550), and 0.25 mg/l vs 0.94 mg/l (P=0.026308), respectively. Significant differences were also revealed in the subgroups differed by age (P=0.0094), platelet count (P=0.001), serum fibrinogen concentration (P=0.016), as well as CURB (P=0.02334), CRB-65 (P=0.032564), and SOFA (P=0.042042) scores. Therefore, s-CysC and u-CysC were statistically significant predictors of death in patients with pneumonia associated with severe and extremely severe COVID-19: 16.273 (95% CI: 2.503–105,814), P=0.003 and 1.281 (95% CI: 1.011–1.622), P=0.040, respectively. Urine and serum CysC were established as predictors of death in pneumonia associated with severe and extremely severe COVID-19, where u-CysC was defined as highly informative (ROC AUC 0.938 (95% CI: 0.867–1.000; P=0.000), with 90% sensitivity and specificity), and s-CysC — as informative (ROC AUC 0.863 (95%CI: 0.738–0.988; P=0.000) with 80% sensitivity and 72% specificity) predictive markers.Conclusion. Levels of S-CysC and u-CysC are of high prognostic significance and may contribute to identifying patients at a high risk of unfavorable outcome (death) due to pneumonia associated with severe and extremely severe COVID-19. Both S-CysC and u-CysC concentrations increasing up to 1.44 mg/l and 0.86 mg/l, respectively, were associated with high probability of death.

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Biomarkers of Air-Blood Barrier Damage In COVID-19

Cited by 6 publications

References 53 publications

Predictors of Mortality in Hospitalized Covid-19 Patients

Predictors of Mortality in Hospitalized Covid-19 Patients

Clinical Utility of Circulating Pneumoproteins as Diagnostic and Prognostic Biomarkers in COVID-19: A Systematic Review and Meta-analysis

Prognostic Value of Cystatin C as a Predictor of Adverse Outcome in Severe Pneumonia Associated with COVID-19

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