Biomarkers in urinary tract infections – which ones are suitable for diagnostics and follow-up?

Horváth, J.; Wullt, Björn; Naber, Kurt G.; Köves, B.

doi:10.3205/id000068

Cited by 17 publications

(14 citation statements)

References 75 publications

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“…Urine microscopy and culture have been considered the diagnostic ‘gold standard’ for decades, despite known suboptimal diagnostic accuracy [ 5 , 6 ]. Promising molecular research, including whole genome and metagenomic sequencing technologies, coupled with an increased understanding of the urinary tract microbiome may improve diagnosis, but are not validated for use in clinical practice [ 7 , 8 ]. While the use of antibiotics in asymptomatic bacteriuria in people without specific risk factors is now universally discouraged, there remains widespread and heterogeneous use in both asymptomatic and symptomatic populations, raising concerns about fuelling the global crisis of emerging multidrug resistance [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Guideline of guidelines: management of recurrent urinary tract infections in women

et al. 2022

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To compare recurrent urinary tract infection (rUTI) guidelines from major urological and non-urological organisations internationally and identify areas of consensus and discrepancy. MethodsPubMed, Google Scholar and the official webpages of major urological, gynaecological, infectious diseases and general practice organisations were searched for rUTI guidelines in March 2022. Nine guidelines were included for review:

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Section: Introductionmentioning

confidence: 99%

Guideline of guidelines: management of recurrent urinary tract infections in women

et al. 2022

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“…Other tests have been studied such as heparin-binding protein product of neutrophil activation, matrix metalloprotease-9 (MMP-9) whose increase occurs simultaneously with NGAL, lactoferrin, and heat shock protein-70 which appear to be promising [47].…”

Section: Other Biomarkers In Urinary Tract Infectionmentioning

confidence: 99%

Non-Microbiological Tests for the Diagnosis of Urinary Tract Infection

Nócua-Báez¹,

Cortés²

2024

Advances and Challenges in Urine Laboratory Analysis

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After clinical evaluation, suspicion of urinary tract infection might be modified by different tests that have the ability to augment (or diminish) the probability of a positive urinary culture and a confirmed diagnosis. In this review, we evaluate the possible role of different non microbiological test for the diagnosis of an urinary tract infection. Some of them might be easily available in the office or a busy emergency room, while others require more sophisticated infrastructure. Due to the high frequency of urinary tract infections, the diversity of symptoms, the difficulty of the diagnosis in some group of patients (e.g., older patients, those with dementia, etc.), and the lack of a gold standard, those non-microbiological tests might contribute to a correct diagnosis and a proper use of antibiotics in difficult cases.

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“…According to the World Health Organization [1], UTIs are a health security problem for many countries, especially developing ones, and they are among the most common types of infection seen in primary and acute care. UTIs are on the rise globally and estimated to account for around 8.6 million healthcare visits annually [2]. Moreover, antibiotic resistance has risen to dangerously high levels globally, and by 2050, it is estimated that 10 million deaths will be due to antimicrobial resistance and that $100 trillion of the global economy will be lost if consistent efforts are not made to contain this threat [4,5].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

Benmoumou

Hamaidi-Chergui

Bouznada

et al. 2023

Advanced Research in Life Sciences

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Urinary tract infections (UTIs) are currently one of the most important medical practice visits. The spread of antibiotic-resistant bacteria in the community complicates the therapeutic management. The aim of this study is to investigate the bacteria associated with community acquired urinary tract infections (CA-UTIs) and the antibiotic resistance pattern of bacterial isolates during 2021 in Algiers, northern Algeria. A total of 548 urine samples from patients with CA-UTIs symptoms were analyzed. Pure bacterial isolates were identified using morphological and biochemical characteristics, and subjected to antibiogram evaluation using the disk diffusion method. A total 133 out of 548 patients (24.27%) had positive CA-UTIs, mainly affecting women (84.21%). A percentage of 87.22% of isolates were identified as Enterobacteriaceae, which were represented mostly by Escherichia coli (76 isolates), Klebsiella pneumoniae (13 isolates), and Proteus mirabilis (13 isolates). A number of 125 isolates (93.98%) were resistant to at least one antibiotic tested. The results showed the highest antibiotic resistance to ampicillin (92.24%) and amoxicillinclavulanic acid (91.37%), and revealed the most sensitivity to cefotaxime and nitrofurantoin (95.69%) and colistin (93.11%). The results of this study revealed high concerns about CA-UTIs caused by multidrug-resistant Enterobacteriaceae.

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Biomarkers in urinary tract infections – which ones are suitable for diagnostics and follow-up?

Cited by 17 publications

References 75 publications

Guideline of guidelines: management of recurrent urinary tract infections in women

Guideline of guidelines: management of recurrent urinary tract infections in women

Non-Microbiological Tests for the Diagnosis of Urinary Tract Infection

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

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