Biomarkers in Tubifex tubifex for the metalaxyl and metalaxyl-M toxicity assessment in artificial sediment

Di, Shanshan; Liu, Ruiquan; Cheng, Cheng; Chen, Li; Zhang, Wenjun; Tian, Zhongnan; Liu, Chunxiao; Zhou, Zhiqiang; Diao, Jinling

doi:10.1007/s11356-016-8128-5

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…The fungicides metalaxyl and azoxystrobin correlated negatively with LPO. Regarding metalaxyl, no studies on its effect on sh LPO were found, however, a test carried out on Tubifex exposed to this fungicide showed that lipid peroxidation was increased, but only after three weeks of exposure (Di et al 2017). At earlier times, this biomarker was at the level of controls and that delayed effect was related to a saturation of the antioxidant systems.…”

Section: Discussionmentioning

confidence: 98%

Biotransformation and oxidative stress responses in fish (Astyanax aeneus) inhabiting a Caribbean estuary contaminated with pesticide residues from agricultural runoff

Mena

Vargas

Guevara-Mora

et al. 2022

Environ Sci Pollut Res

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The estuarine ecosystem of Laguna Madre de Dios (LMD), in the Caribbean coast of Costa Rica, is exposed to contamination with pesticide residues coming from the upstream agricultural areas. Biomarkers can provide a better indication of the tness of biota in real mixture exposure scenarios than traditional lethal dose toxicity measurements. Here, we measured biomarkers of biotransformation, oxidative stress and neurotoxicity on Astyanax aeneus, an abundant sh species in LMD. Glutathione Stransferase activity (GST), catalase activity (CAT), lipid peroxidation (LPO), and cholinesterase activity (ChE) were measured in sh collected during seven sampling campaigns, carried out between 2016 and 2018. Pesticide residues were analysed in surface water samples collected every time sh were sampled.Residues of 25 pesticides, including fungicides, insecticides and herbicides, were detected. The biomarkers measured in A. aeneus varied along the sampling moments, however, biotransformation and oxidative stress signals showed coupled responses throughout the assessment. Furthermore, signi cant correlations were established between three biomarkers (GST, LPO and CAT) and individual pesticides, as well as between GST and LPO with groups of pesticides with shared biocide action. Among pesticides, insecticide residues had a major in uence on the responses observed in sh. This work shows that the frequent exposure to environmentally relevant concentrations of pesticides can be related to physiological responses in sh that affect their health. This early warning information should be considered to improve the protection of estuarine ecosystems in the tropics.

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Section: Discussionmentioning

confidence: 98%

Biotransformation and oxidative stress responses in fish (Astyanax aeneus) inhabiting a Caribbean estuary contaminated with pesticide residues from agricultural runoff

Mena

Vargas

Guevara-Mora

et al. 2022

Environ Sci Pollut Res

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“…Due to the double-phase life mode, it plays an essential role in the aquatic ecosystem. They live in water and sediment [18]. The Tubifex ingests sediment particles and feeds on fine organic matter [19].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dufulin on Oxidative Stress and Metabolomic Profile of Tubifex

Zhu

Yang

et al. 2021

Metabolites

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Dufulin is a highly effective antiviral pesticide used in plants. In this study, a seven-day experiment was conducted to evaluate the effects of Dufulin at five different concentrations (1 × 10−4, 1 × 10−3, 1 × 10−2, 0.1, and 1 mg/L) on Tubifex. LC-MS-based metabolome analysis detected a total of 5356 features in positive and 9110 features in negative, of which 41 showed significant changes and were identified as differential metabolites. Four metabolic pathways were selected for further study. Detailed analysis revealed that Dufulin exposure affected the urea cycle of Tubifex, probably via argininosuccinate lyase (ASL) inhibition. It also affected the fatty acid metabolism, leading to changes in the concentration of free fatty acids in Tubifex. Furthermore, the changes in metabolites after exposure to Dufulin at 1 × 10−2 mg/L were different from those at the other concentrations.

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“…Tubifex , as a typical aquatic benthos that lives at the sediment–water interface, can be exposed to environmental pollutants through sediments, porewater and water columns, ingestion, and epidermal contact (Arendarczyk et al 2014; Di et al 2016b). Tubifex is considered ecologically relevant because of its wide distribution and frequent domination of the macrobiotic community in freshwater habitats (Mosleh et al 2005a; Di et al 2013, 2014).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Enantioselective Degradation of Dufulin on Tubifex

Jiang

Song

Wang

et al. 2020

Enviro Toxic and Chemistry

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Dufulin is a new type of chiral antiplant virus agent independently developed in China. The present study was conducted to determine the effects of different concentrations of rac-dufulin and dufulin enantiomers (1, 5, and 10 mg/L) on oxidative stress in Tubifex after exposure for 3, 7, and 14 d. Results showed that rac-dufulin and individual enantiomers had no significant effects on total protein content and glutathione reductase activities. Increased superoxide dismutase demonstrated the generation of superoxide anion radical. The increase in glutathione S-transferase may be due to detoxification mechanisms. The different changes in catalase activities could be due to oxidative stress. The increase in malondialdehyde may be due to the accumulation and toxicity of contaminations. The degradation behavior of dufulin enantiomers was studied through spiked-water and spiked-soil tests. The degradation rate of S-(+)-dufulin was faster than that of R-(−)-dufulin. The present study demonstrated the occurrence of enantioselectivity in the degradation and oxidative stress of dufulin to Tubifex. In spiked soil, the concentrations of dufulin enantiomers in underlying soil were significantly higher than those in overlying water; but after 5 d of degradation, the bioturbation of Tubifex could facilitate part of dufulin diffusing from the underlying soil into the overlying water and altered the partitioning of dufulin. The present study provided a basis for conducting environmental safety risk assessments and rationally using dufulin as a chiral pesticide.

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Biomarkers in Tubifex tubifex for the metalaxyl and metalaxyl-M toxicity assessment in artificial sediment

Cited by 10 publications

References 30 publications

Biotransformation and oxidative stress responses in fish (Astyanax aeneus) inhabiting a Caribbean estuary contaminated with pesticide residues from agricultural runoff

Biotransformation and oxidative stress responses in fish (Astyanax aeneus) inhabiting a Caribbean estuary contaminated with pesticide residues from agricultural runoff

Effects of Dufulin on Oxidative Stress and Metabolomic Profile of Tubifex

Oxidative Stress and Enantioselective Degradation of Dufulin on Tubifex

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