Biomarkers in saliva as diagnostic tool in early diagnosis of oral submucous fibrosis

Mandal, Yagnaseni; Jha, Kunal; Jnaneswar, Avinash

doi:10.4103/jpcdoh.jpcdoh_9_20

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…In our research, we discovered that the least amount of people is aware of the impact of acid–base balance on periodontal pockets. [ 22 ] This is in line with the findings of Axelsson and Lindhe, who investigated the impact of regulated oral hygiene techniques on caries and periodontal disease in adults and concluded that dental caries and periodontal disease are the outcomes of poor oral hygiene.…”

Section: Discussionsupporting

confidence: 86%

Awareness about the significance of acid–base balance of saliva in maintaining oral health

Suresh

Vishnupriya

Jayaraman

et al. 2022

J Adv Pharm Technol Res

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Section: Discussionsupporting

confidence: 86%

Awareness about the significance of acid–base balance of saliva in maintaining oral health

Suresh

Vishnupriya

Jayaraman

et al. 2022

J Adv Pharm Technol Res

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“…These biomarkers were detected by methylated polymerase chain reaction (PCR), real-time PCR, western blotting, and staining procedures. 5 6 However, the biopsy sometimes is an invasive procedure with low patient acceptance. Liquid biopsy shows the noninvasive detection of components in biofluids, such as blood serum and saliva.…”

Section: Introductionmentioning

confidence: 99%

Salivary Profile in Oral Submucous Fibrosis: A Scoping Review

Mahdani,

Subarnbhesaj,

Ayuningtyas

et al. 2024

Eur J Dent

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Diagnosing oral submucous fibrosis (OSMF) is invariably challenging. The disease can be detected after reaching its final stage and requires complex treatment. Changes in its salivary profile can be used as a reference to see this disorder and as a basis for diagnostic prediction. This study is aimed to analyze the salivary profile as a diagnosis marker in patients with OSMF. The study using Preferred Reporting Items for Systematic Reviews and Meta-analyses was conducted using PubMed, Science Direct, and Scopus databases. A thorough literature search between 1991 and 2023 was performed. Twenty-eight full-text articles were reviewed in detail. Twenty-eight articles were included; a total of 929 patients of OSMF and 826 controls were found. The scoping review showed that levels of salivary protein (including lactate hydrogenase, immunoglobulin G, immunoglobulin A, S1007A protein, 8-hydroxydeoxyguanosine, 8-isoprostane, malondialdehyde, matrix metalloproteinase-12, salivary C-reactive protein, fibrinogen producing factor, salivary miRNA-21, and salivary lipids [cholesterol, high-density lipoprotein, triglyceride) were higher in OSMF. Meanwhile, trace elements (vitamin C, vitamin E, iron, zinc, and magnesium) were lower; only copper was higher in OSMF patients. Alteration in salivary components such as protein, lipid, and trace elements detection can be a basis for providing a noninvasive supportive examination and thus be used as a diagnosis marker of OSMF.

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Biomarkers in saliva as diagnostic tool in early diagnosis of oral submucous fibrosis

Cited by 2 publications

References 15 publications

Awareness about the significance of acid–base balance of saliva in maintaining oral health

Awareness about the significance of acid–base balance of saliva in maintaining oral health

Salivary Profile in Oral Submucous Fibrosis: A Scoping Review

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