Biomarkers in low cardiac output syndrome after open cardiac surgery in children

Kusumajaya, Reby; Advani, Najib; Yanuarso, Piprim B.; Effendy, Zulham

doi:10.14238/pi61.4.2021.223-8

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…In this review, the postoperative calciferol status of pediatric patients with CHD was correlated with the need for inotropic support and mechanical ventilation. In critical conditions, calciferol supplementation can be administered to suppress various inflammatory responses that may occur during treatment (Cariolou et al 2019, Kusumajaya et al 2021.…”

Section: Discussionmentioning

confidence: 99%

Calciferol Status and Clinical Outcomes in Children with Congenital Heart Disease after Heart Surgery

Zulham Effendy,

Tri Yanti Rahayuningsih,

Fachrul Razi

et al. 2023

FMI

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Highlights: Calciferol has cardioprotective properties, and a severe deficiency of calciferol is associated with septic shock, a longer duration of mechanical ventilation and treatment in the intensive care unit, and mortality. The role of calciferol in critical conditions has been described in several research reports, but relatively little is known about its function in pediatric cardiac surgery. Abstract Calciferol is a micronutrient and a secosteroid hormone that plays a role in maintaining the health of bones and soft tissues in the body, such as the myocardium, as well as the immune system. Hypovitaminosis D has been reported to be associated with poor clinical outcomes and child mortality in pediatric intensive care units. Children with congenital heart disease (CHD) are vulnerable to critical conditions and require early intervention due to heart failure. This study aimed to investigate the influence of calciferol status on the clinical outcomes of pediatric CHD patients who underwent heart surgery. A systematic literature review was conducted using the electronic databases from PubMed, Elsevier, and Cochrane. This study included observational and randomized control studies that assessed the calciferol status of pediatric CHD patients undergoing cardiac surgery. From a total of 168 studies, 8 studies were selected for review. The preoperative and postoperative calciferol status as well as clinical outcomes following pediatric cardiac surgery were reviewed. According to the findings, most pediatric CHD patients suffered from calciferol deficiency prior to corrective heart surgery, which further decreased postoperatively and was associated with clinical outcomes in the intensive care unit (ICU). Preoperative calciferol supplementation has been reported to enhance serum calciferol levels and is associated with good clinical outcomes in pediatric patients undergoing cardiac surgery.

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Section: Discussionmentioning

confidence: 99%

Calciferol Status and Clinical Outcomes in Children with Congenital Heart Disease after Heart Surgery

Zulham Effendy,

Tri Yanti Rahayuningsih,

Fachrul Razi

et al. 2023

FMI

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“…In recent years, the neutrophil-to-lymphocyte ratio (NLR) has become an inflammatory marker that has the potential to be used in various conditions, one of which is cardiovascular disorders [12,13]. NLR is a potential marker of inflammation to determine the presence of inflammation [12,13]. NLR was chosen because it is considered superior, frequently used, easy to calculate, and cheaper than other inflammatory markers [14].…”

Section: Original Articlementioning

confidence: 99%

Neutrophil-to-lymphocyte ratio as a predictor of low cardiac output syndrome after open heart surgery in children with congenital heart disease

Laila,

Perdana,

Permatasari

et al. 2024

Narra J

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Neutrophil-to-lymphocyte ratio (NLR) as a predictor in determining low cardiac output syndrome (LCOS) has not been widely reported. The aim of this study was to explore the role of pre-surgery, 0-, 4-, and 8-hour post-surgery NLR as predictors of LCOS incidence after open heart surgery in children with congenital heart disease (CHD). This study used a prognostic test with a prospective cohort design and was conducted from December 2020 until June 2021 at the cardiac intensive care unit (CICU) of Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. The subject consisted of children aged one month to 18 years who underwent open heart surgery using a cardiopulmonary bypass (CPB) machine. A receiver operating characteristic curve was applied to identify the predictive performance of NLR for poor outcomes (LCOS incidence). Out of 90 patients included in the study, 25 (27.8%) of them developed LCOS between 3 to 53 hours post-surgery. All NLR values (pre-surgery and 0-, 4-, and 8-hours post-surgery) were associated with the incidence of LCOS. Pre-surgery NLR (cut-off value ≥0.88) had a fair predictive value (area under curve (AUC) 70; 95%CI: 57–83) for predicting LCOS incidence with sensitivity and specificity of 64% and 64.62%, respectively. NLR 0-hour post-surgery (cut-off value ≥4.73) had a good predictive value (AUC 81; 95%CI: 69–94) for predicting LCOS incidence, with 80% sensitivity and 80% specificity. NLR 4- and 8-hours post-surgery had very good predictive values (AUC 97%; 95%CI: 92–100 and 98; 95%CI: 94–100, respectively), with cut-off values ≥6.19 and ≥6.78, had the same 92% sensitivity and the same 96% sensitivity. The presence of LCOS was associated with mortality (odds ratio of 5.11 with 95%CI: 3.09–8.46). This study highlights that pre-surgery, 0-, 4-, and 8-hours post-surgery NLR can be predictors of LCOS after open heart surgery in children with CHD.

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Biomarkers in low cardiac output syndrome after open cardiac surgery in children

Cited by 2 publications

References 18 publications

Calciferol Status and Clinical Outcomes in Children with Congenital Heart Disease after Heart Surgery

Calciferol Status and Clinical Outcomes in Children with Congenital Heart Disease after Heart Surgery

Neutrophil-to-lymphocyte ratio as a predictor of low cardiac output syndrome after open heart surgery in children with congenital heart disease

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